| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2020: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2019: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2018: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2017: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
Gene expression patterns exhibit dynamic changes as cells differentiate and respond to external signals. To understand the significance of histone modifications in transcriptional activation and inactivation, we conducted this study using a unique system for visualizing post-translational modifications in living cells. In transcriptional activation, we found that acetylation of histone H3 is important for heat shock stress-induced transcriptional activation. In addition, we showed how methylation of histone H3 and H4 accumulates during X-chromosome inactivation during mouse embryonic stem cell differentiation.
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