| Budget Amount *help |
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2019: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2018: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2017: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
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| Outline of Final Research Achievements |
Protein must gain correct tertiary and quaternary structure to fulfill its function assigned by the genetic code. Misfolded proteins are harmful to the cell. Misfolded proteins accumulated in the endoplasmic reticulum (ER), an organelle, are dealt with ER-associated degradation (ERAD). We unraveled a mechanism of ERAD. In the case of misfolded glycoproteins, the structure of N-glycan is recognized for degradation. We proposed that an enzyme termed EDEN2 initiates the first step of ERAD of misfolded glycoproteins. We demonstrated that EDEM2 indeed catalyzes the first step, only when complexed with TXNDC11 (eLife, 2020).
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