Meiotic chromatin structures for organizing homologous chromosome recombination
| Project/Area Number |
17H01444
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2019: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2017: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Keywords | 染色体 / 細胞核 / 細胞 |
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| Outline of Final Research Achievements |
DNA replication is important for pairing, recombination, and segregation of homologous chromosomes in meiosis. We analyzed chromatin structures required for DNA replication, pairing, and recombination, and obtained he following results. (1) Positioning of chromosomes within the nucleus affects the timing of DNA replication. (2) Chromatin structures produced by meiotic cohesins is essential for pairing homologous chromosomes. (3) A histone H2A variant, H2A.z, plays an important role in recombination of homologous chromosomes. (4) The molecular balance of histone species is important for the normal progression of chromosome segregation.
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| Academic Significance and Societal Importance of the Research Achievements |
減数分裂は、ヒトなどでは２倍体の体細胞から卵子や精子のような１倍体の配偶子を作る特殊な細胞分裂がそれに相当し、そこでの異常は不妊やダウン症などの異常につながるために、減数分裂の仕組みの解明は世代を越えたゲノムの継承を保証するために、学術的にも社会的にも重要な課題となっている。しかし、ヒトで減数分裂の過程や分子メカニズムを解明するのは困難である。解析が容易な分裂酵母で得られた成果は、ヒトをはじめとする真核生物に普遍的な仕組みの理解につながり、学術的にも社会的にも重要である。
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Report
(4 results)
Research Products
(51 results)
