| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2019: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2017: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
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| Outline of Final Research Achievements |
DNA replication is important for pairing, recombination, and segregation of homologous chromosomes in meiosis. We analyzed chromatin structures required for DNA replication, pairing, and recombination, and obtained he following results. (1) Positioning of chromosomes within the nucleus affects the timing of DNA replication. (2) Chromatin structures produced by meiotic cohesins is essential for pairing homologous chromosomes. (3) A histone H2A variant, H2A.z, plays an important role in recombination of homologous chromosomes. (4) The molecular balance of histone species is important for the normal progression of chromosome segregation.
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