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Characterization of endosymbiotic evolution by focusing on the mechanisms for coping with photosynthetic oxidative stress

Research Project

Project/Area Number 17H01446
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Evolutionary biology
Research InstitutionNational Institute of Genetics

Principal Investigator

Miyagishima Shin-ya  国立遺伝学研究所, 遺伝形質研究系, 教授 (00443036)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000)
Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2018: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2017: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords細胞内共生 / 光合成 / 酸化ストレス / 細胞分裂 / 葉緑体
Outline of Final Research Achievements

It is believed that chloroplasts were established through predation and the temporary or facultative retention of photosynthetic prey and then permanent endosymbiotic relationship with photosynthetic organisms (or chloroplasts) by a unicellular eukaryotic host cell. In this study, we have analyzed how organisms in different stages of endosymbiotic evolution cope with photosynthetic oxidative stress. We have found that some mechanisms for coping with photosynthetic oxidative stress had been acquired stepwisely in prey-predator and temporal endosymbiotic relationships before establishment of permanent endosymbiotic relationships (chloroplasts).

Academic Significance and Societal Importance of the Research Achievements

光合成酸化ストレスへの対処機構は、すでに葉緑体との絶対共生関係を確立させている真核藻類・植物においての研究例があったが、本研究により、捕食―被食関係の段階においても真核藻類・植物に見られる機構の一部が成立していたことが初めて明らかとなった。また、これまでほとんど不明であった細胞内共生進化の初期段階について、絶対共生関係を構築するために必要な機構や遺伝子群を、宿主細胞が捕食―被食関係の段階から漸進的に獲得したという知見が得られた。これらの結果は、細胞内共生進化を理解するために重要な、これまでになかった視点からの発見である。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (16 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 10 results)

  • [Journal Article] Responses of unicellular predators to cope with the phototoxicity of photosynthetic prey.2019

    • Author(s)
      Uzuka, A., Kobayashi, Y., Onuma, R., Hirooka, S., Kanesaki, Y., Yoshikawa, H., Fujiwara, T., Miyagishima, S.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41467-019-13568-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Day/night separation of oxygenic energy metabolism and nuclear DNA replication in the unicellular red alga Cyanidioschyzon merolae2019

    • Author(s)
      Miyagishima, S., Era, A., Hasunuma, T., Matsuda, M., Hirooka, S., Sumiya, N., Kondo, A., Fujiwara, T.
    • Journal Title

      mBio

      Volume: 10 Issue: 4

    • DOI

      10.1128/mbio.00833-19

    • NAID

      120006733160

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integration of a Galdieria plasma membrane sugar transporter enables heterotrophic growth of the obligate photoautotrophic red alga Cynanidioschyzon merolae2019

    • Author(s)
      Fujiwara Takayuki、Hirooka Shunsuke、Mukai Mizuna、Ohbayashi Ryudo、kanesaki Yu、Watanabe Satoru、Miyagishima Shin-ya
    • Journal Title

      Plant Direct

      Volume: 3 Issue: 4

    • DOI

      10.1002/pld3.134

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Integration of a Galdieria plasma membrane sugar transporter enables heterotrophic growth of the obligate photoautotrophic red alga Cynanidioschyzon merolae2019

    • Author(s)
      Fujiwara, T., Hirooka, S., Mukai, M., Ohbayashi, R., kanesaki, Y., Watanabe, S., and Miyagishima, S.
    • Journal Title

      Plant Direct

      Volume: in press

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acidophilic green algal genome provides insights into adaptation to an acidic environment2017

    • Author(s)
      Hirooka, S., Hirose, Y., Kanesaki, Y., Higuchi, S., Fujiwara, T., Onuma, R., Era, A., Ohbayashi, R., Uzuka, A., Nozaki, H., Yoshikawa, H., and Miyagishima, S.
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 114 Issue: 39

    • DOI

      10.1073/pnas.1707072114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 藻食単細生物における餌の光毒性に対する対処機構2019

    • Author(s)
      宮城島 進也,宇塚 明洋,小林 優介,大沼 亮,廣岡 俊亮,藤原 崇之
    • Organizer
      日本植物学会第83回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞内共生による光合成真核生物の成立と光合成の毒性への対処2019

    • Author(s)
      宮城島 進也
    • Organizer
      第13回日本ゲノム微生物学会年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞内共生と光合成生物の進化・多様化2018

    • Author(s)
      宮城島 進也
    • Organizer
      第51回日本原生生物学会公開シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Cyanidiales for interdisciplinary and international studies2018

    • Author(s)
      Shin-ya Miyagishima
    • Organizer
      International Symposium: Cyanidioschyzon merolae as an arising model for unicellular eukaryotes
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 細胞内共生による葉緑体の獲得光合成の毒性による制約2018

    • Author(s)
      宮城島 進也
    • Organizer
      日本植物学会第82回大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリアと葉緑体のようなエネルギー変換器はどの様に誕生したか-微細藻類を用いて細胞内共生による生命進化を探る2018

    • Author(s)
      宮城島 進也
    • Organizer
      大隅基礎科学創成財団 第三回創発セミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 細胞内共生に関する基礎研究と 産業利用に向けた研究における微細藻類の利用2017

    • Author(s)
      宮城島 進也
    • Organizer
      ナショナルリソースプロジェクト公開成果報告会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 真核宿主細胞と細胞内共生体由来オルガネラの協調増殖機構2017

    • Author(s)
      宮城島 進也
    • Organizer
      第17回名古屋大学遺伝子実験施設公開セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 真核細胞と葉緑体・光合成性細胞内共生体の協調増殖機構2017

    • Author(s)
      宮城島 進也
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 真核宿主細胞と細胞内共生オルガネラの協調増殖機2017

    • Author(s)
      宮城島 進也
    • Organizer
      日本進化学会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 真核細胞と葉緑体・光合成性細胞内共生体の時間分業による協調増殖機構2017

    • Author(s)
      宮城島 進也
    • Organizer
      生物リズム若手研究者の集い2017
    • Related Report
      2017 Annual Research Report
    • Invited

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Published: 2017-04-28   Modified: 2022-01-27  

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