| Budget Amount *help |
¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000)
Fiscal Year 2020: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2019: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2018: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2017: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Outline of Final Research Achievements |
The objective of this project is to explore RNA silencing (RNAi) against fungal viruses in plant pathogenic filamentous fungi. A great progress has been made, leading to several breakthroughs: 1) Discovery of RNAi mediated antiviral defense that requires Dicer but not AGO in the chestnut blight fungus, 2) Identification of the SAGA complex as a transcriptional regulator of fungal RNA silencing, 3) Discovery of a novel antiviral defense mechanism by which virus-induced symptom expression is alleviated by transcriptional upregulation of many host genes upon virus infection in C. parasitica, and 4) Identification of Dicer and SAGA (universal transcriptional coactivator) as the key transcriptional regulators in the new defense, indicating the dual role of Dicer at the post-transcriptional and transcriptional levels. These findings will bring about a paradigm shift in RNAi. Fungi are now being established as the third position next to animals and plants in antiviral defense research.
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