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Creation of next-generation pest control drugs by elucidation of the indirect defence mechanism of plants

Research Project

Project/Area Number 17H01472
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioorganic chemistry
Research InstitutionKindai University

Principal Investigator

Matsuda Kazuhiko  近畿大学, 農学部, 教授 (00199796)

Co-Investigator(Kenkyū-buntansha) 丹羽 隆介  筑波大学, 生存ダイナミクス研究センター, 教授 (60507945)
作田 庄平  帝京大学, 理工学部, 教授 (80192087)
加藤 直樹  国立研究開発法人理化学研究所, 環境資源科学研究センター, 研究員 (90442946)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2020: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2019: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2018: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2017: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Keywords間接誘導防衛機構 / 植物ケミカルシグナル / 昆虫活性物質 / 糸状菌 / 放線菌 / 二次代謝 / 生合成 / 昆虫神経活性 / 間接誘導防衛 / 微生物 / 植物化学シグナル / 昆虫変態活性 / 昆虫制御物質 / ターゲット解明 / 微生物の二次代謝 / 高選択的昆虫制御 / 神経イオンチャネル / 昆虫の変態
Outline of Final Research Achievements

This study aimed to clarify the indirect defence mechanism in the plant rhizosphere and identify the target molecules of the defence compounds produced by symbionts for plant protection. The PI purified soybean signals stimulating okaramine biosynthesis in Penicillium simplicissimum, while uncovering the okaramine biosynthesis genes in the fungus. The PI also discovered co-factors enabling functional expression of insect nicotinic acetylcholine receptors (nAChRs). The Co-Is found that fungal products decalins inhibited the Noppera-bo protein underpinning ecdysteroid biosynthesis in the fruit fly Drosophila melanogaster. Metabolome analysis of soils used to cultivate soybean plants after growing hairy vetch led to the finding of okaramines. Some Streptomyces microorganisms produce allosamidin that inhibits chitinases and chitinase like proteins. The Co-I found that allosamidin had activity to promote plant lateral root formation, providing new insight into the indirect defence.

Academic Significance and Societal Importance of the Research Achievements

本研究では計画通り「間接誘導防衛機構」を駆動する植物のケミカルシグナルの実態を把握し、Penicillium simplicissimumによる殺虫性物質オカラミンの生合成経路を解明した。その一方で、緑肥施用後に生育させたダイズの根圏でオカラミンが多量に蓄積されることを観察し、本機構が実在することを確認できたことは意義がある。また、間接誘導防衛機構に関わる放線菌の生産物アロサミジンが植物の側根形成を促進するという発見も、本機構の応用を後押しする。さらに、昆虫のニコチン性アセチルコリン受容体の機能的発現に成功したことは、本受容体を標的とする化合物の毒性評価の精度を飛躍的に高める大きな成果である。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (64 results)

All 2021 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (20 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 19 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (42 results) (of which Int'l Joint Research: 7 results,  Invited: 8 results) Remarks (1 results)

  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] β-1,3-Glucanases and chitinases participate in the stress-related defence mechanisms that are possibly connected with modulation of arabinogalactan proteins (AGP) required for the androgenesis initiation in rye (Secale cereale L.)2021

    • Author(s)
      Zielinski Kamil、Dubas Ewa、Gersi Zuzana、Krzewska Monika、Janas Agnieszka、Nowicka Anna、Matusikova Ildiko、Zur Iwona、Sakuda Shohei、Moravcikova Jana
    • Journal Title

      Plant Science

      Volume: 302 Pages: 110700-110700

    • DOI

      10.1016/j.plantsci.2020.110700

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 根圏における植物の間接誘導防衛機構の最前線2020

    • Author(s)
      松田 一彦、櫻井 望、藤井 義晴、杉山 暁史
    • Journal Title

      KAGAKU TO SEIBUTSU

      Volume: 58 Issue: 6 Pages: 325-329

    • DOI

      10.1271/kagakutoseibutsu.58.325

    • NAID

      130008046471

    • ISSN
      0453-073X, 1883-6852
    • Year and Date
      2020-06-01
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Cofactor-enabled functional expression of fruit fly, honeybee, and bumblebee nicotinic receptors reveals picomolar neonicotinoid actions2020

    • Author(s)
      Ihara Makoto、Furutani Shogo、Shigetou Sho、Shimada Shota、Niki Kunihiro、Komori Yuma、Kamiya Masaki、Koizumi Wataru、Magara Leo、Hikida Mai、Noguchi Akira、Okuhara Daiki、Yoshinari Yuto、Kondo Shu、Tanimoto Hiromu、Niwa Ryusuke、Sattelle David B.、Matsuda Kazuhiko
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 28 Pages: 16283-16291

    • DOI

      10.1073/pnas.2003667117

    • NAID

      120007163383

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modulation by neonicotinoids of honeybee α1/chicken β2 hybrid nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes2020

    • Author(s)
      Shigetou Sho、Shimada Shota、Makoto Ihara、Matsuda Kazuhiko
    • Journal Title

      Pesticide Biochemistry and Physiology

      Volume: 166 Pages: 104545-104545

    • DOI

      10.1016/j.pestbp.2020.02.011

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests2020

    • Author(s)
      Shimada Shota、Kamiya Masaki、Shigetou Sho、Tomiyama Kakeru、Komori Yuma、Magara Leo、Ihara Makoto、Matsuda Kazuhiko
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 7529-7529

    • DOI

      10.1038/s41598-020-64258-z

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolome Analysis Identified Okaramines in the Soybean Rhizosphere as a Legacy of Hairy Vetch2020

    • Author(s)
      Sakurai Nozomu、Mardani-Korrani Hossein、Nakayasu Masaru、Matsuda Kazuhiko、Ochiai Kumiko、Kobayashi Masaru、Tahara Yusuke、Onodera Takeshi、Aoki Yuichi、Motobayashi Takashi、Komatsuzaki Masakazu、Ihara Makoto、Shibata Daisuke、Fujii Yoshiharu、Sugiyama Akifumi
    • Journal Title

      Frontiers in Genetics

      Volume: 11 Pages: 114-114

    • DOI

      10.3389/fgene.2020.00114

    • NAID

      120006800708

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neonicotinoid Insecticides: Molecular Targets, Resistance, and Toxicity2020

    • Author(s)
      Matsuda Kazuhiko、Ihara Makoto、Sattelle David B.
    • Journal Title

      Annual Review of Pharmacology and Toxicology

      Volume: 60 Issue: 1 Pages: 241-255

    • DOI

      10.1146/annurev-pharmtox-010818-021747

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A unique primary structure of RDL (resistant to dieldrin) confers resistance to GABA‐gated chloride channel blockers in the two‐spotted spider mite Tetranychus urticae Koch2020

    • Author(s)
      Kobayashi Takeru、Hiragaki Susumu、Suzuki Takeshi、Ochiai Noriaki、Canlas Liza J.、Tufail Muhammad、Hayashi Naotaka、Mohamed Ahmed A.M.、Dekeyser Mark A.、Matsuda Kazuhiko、Takeda Makio
    • Journal Title

      Journal of Neurochemistry

      Volume: 155 Issue: 5 Pages: 508-521

    • DOI

      10.1111/jnc.15179

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure and biological activity of metarhizin C, a new stereoisomer of BR-050 from a fungus Tolypocladium album RK17-F00072019

    • Author(s)
      Nogawa T., Kawatani M., Okano A., Futamura Y., Aono H., Shimizu T., Kato N., Kikuchi H., and Osada H.
    • Journal Title

      J. Antibiot.

      Volume: 72 Issue: 12 Pages: 996-1000

    • DOI

      10.1038/s41429-019-0229-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Okaramines and other plant fungal products as new insecticide leads2018

    • Author(s)
      Matsuda Kazuhiko
    • Journal Title

      Current Opinion in Insect Science

      Volume: 30 Pages: 67-72

    • DOI

      10.1016/j.cois.2018.09.010

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neonicotinoids: molecular mechanisms of action, insights into resistance and impact on pollinators2018

    • Author(s)
      Ihara Makoto、Matsuda Kazuhiko
    • Journal Title

      Current Opinion in Insect Science

      Volume: 30 Pages: 86-92

    • DOI

      10.1016/j.cois.2018.09.009

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined effects of mutations in loop C and the loop D-E-G triangle on neonicotinoid interactions with Drosophila Dα1/chicken β2 hybrid nAChRs2018

    • Author(s)
      Hikida Mai,Shimada Shota, Kurata Ryo, Shigetou Sho, Ihara Makoto, Sattelle David B., Matsuda Kazuhiko
    • Journal Title

      Pesticide Biochemistry and Physiology

      Volume: 印刷中 Pages: 47-52

    • DOI

      10.1016/j.pestbp.2018.03.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease2018

    • Author(s)
      Furutani Shogo、Ihara Makoto、Lees Kristin、Buckingham Steven D.、Partridge Frederick A.、David Jonathan A.、Patel Rohit、Warchal Scott、Mellor Ian R.、Matsuda Kazuhiko、Sattelle David B.
    • Journal Title

      International Journal for Parasitology: Drugs and Drug Resistance

      Volume: 8 Issue: 2 Pages: 350-360

    • DOI

      10.1016/j.ijpddr.2018.06.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Control of the stereochemical course of [4+2] cycloaddition during trans-decalin formation by Fsa2-family enzymes2018

    • Author(s)
      Kato N, Nogawa T, Takita R, Kinugasa K, Kanai M, Uchiyama M, Osada H, Takahashi S
    • Journal Title

      Angew Chem Int Ed Engl

      Volume: 57 Issue: 31 Pages: 9754-9758

    • DOI

      10.1002/anie.201805050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosynthesis and structure activity relationship studies of okaramines that target insect glutamate-gated chloride channels2018

    • Author(s)
      Kato Naoki、Furutani Shogo、Otaka Junnosuke、Noguchi Akira、Kinugasa Kiyomi、Kai Kenji、Hayashi Hideo、Ihara Makoto、Takahashi Shunji、Matsuda Kazuhiko、Osada Hiroyuki
    • Journal Title

      ACS Chemical Biology

      Volume: 13 Issue: 3 Pages: 561-566

    • DOI

      10.1021/acschembio.7b00878

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori2017

    • Author(s)
      Shogo Furutani, Makoto Ihara, Kenji Kai, Keiji Tanaka, David B. Sattelle, Hideo Hayashi, Kazuhiko Matsuda
    • Journal Title

      Neurotoxicology

      Volume: 印刷中 Pages: 240-244

    • DOI

      10.1016/j.neuro.2016.05.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Modes of action, resistance and toxicity of insecticides targeting nicotinic acetylcholine receptors.2017

    • Author(s)
      Ihara M, Buchingham SD, Matusda K, Sattelle DB
    • Journal Title

      Current Medicinal Chemistry

      Volume: 24 Issue: 27 Pages: 1-10

    • DOI

      10.2174/0929867324666170206142019

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mechanisms of Action, Resistance and Toxicity of Insecticides Targeting GABA Receptors2017

    • Author(s)
      Buckingham Steven D.、Ihara Makoto、Sattelle David B.、Matsuda Kazuhiko
    • Journal Title

      Current Medicinal Chemistry

      Volume: 24 Issue: 27 Pages: 2935-2945

    • DOI

      10.2174/0929867324666170613075736

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Splice Variants of pH-Sensitive Chloride Channel Identify a Key Determinant of Ivermectin Sensitivity in the Larvae of the Silkworm Bombyx mori2017

    • Author(s)
      Okuhara Daiki、Furutani Shogo、Ito Katsuhiko、Ihara Makoto、Matsuda Kazuhiko
    • Journal Title

      Molecular Pharmacology

      Volume: 92 Issue: 4 Pages: 491-499

    • DOI

      10.1124/mol.117.109199

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An L319F mutation in transmembrane region 3 (TM3) selectively reduces sensitivity to okaramine B of the Bombyx mori l-glutamate-gated chloride channel2017

    • Author(s)
      Furutani Shogo、Okuhara Daiki、Hashimoto Anju、Ihara Makoto、Kai Kenji、Hayashi Hideo、Sattelle David B.、Matsuda Kazuhiko
    • Journal Title

      Bioscienece, Biotechnology, and Biochemistry

      Volume: 81 Issue: 10 Pages: 1861-1867

    • DOI

      10.1080/09168451.2017.1359487

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] セイヨウミツバチ由来ニコチン性アセチルコリン受容体の機能発現法の確立2021

    • Author(s)
      伊原 誠、小森 勇磨、神谷 昌輝、松田 一彦
    • Organizer
      日本農薬学会第46回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 昆虫ニコチン性アセチルコリン受容体の再構築とネオニコチノイドの活性2021

    • Author(s)
      伊原 誠、小森 勇磨、神谷 昌輝、小泉 航、吉成 祐人、丹羽 隆介、David B. Sattelle、松田 一彦
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] スピロコハク酸イミド構造をもつ殺線虫活性物質の標的サブタイプ選択性のメカニズム2021

    • Author(s)
      小泉 航、伊原 誠、松田 一彦
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] コムネシン類の標的活性化作用の構造活性相関2021

    • Author(s)
      矢野 雄大、伊原 誠、甲斐 建次、林 英雄、松田 一彦
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] フラボノイド化合物による昆虫ステロイドホルモン生合成酵素Noppera-boの阻害:構造生物学的解析と生物活性検定2021

    • Author(s)
      海老原 佳奈、稲葉 和恵、小祝 孝太郎、髙谷 大輔、渡邉 千鶴、今村 理世、小島 宏建、岡部 隆義、佐久間 知佐子、嘉糠 洋陸、藤川 雄太、井上 英史、本間 光貴、千田 俊哉、丹羽 隆介
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] デカリン合成酵素Phm7およびFsa2のin vitroアッセイ系の構築2021

    • Author(s)
      加藤 直樹、藤山 敬介、野川 俊彦、長田 裕之、永野 真吾、高橋 俊二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 昆虫の神経イオンチャネルと除虫菊によるピレスリン生合成の制御に関する化学生物学的研究2021

    • Author(s)
      松田一彦
    • Organizer
      日本農芸化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Structure-activity relationship analysis of mosquito glutathione S-transferase Noppera-bo and its inhibitors for insecticide development2020

    • Author(s)
      Kazue Inaba, Kotaro Koiwai, Kana Ebihara, Ryunosuke Yoshino, Takatsugu Hirokawa, Kana Morohashi, Sora Enya, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Hideshi Inoue, Yuuta Fujikawa, Chisako Sakuma, Hirotaka Kanuka, Fumiaki Yumoto, Toshiya Senda, Ryusuke Niwa
    • Organizer
      American Crystallographic Association (ACA) 2020 Virtual Meeting
    • Related Report
      2020 Annual Research Report
  • [Presentation] Toward Safer Insecticides with Pest Species Selectivity2020

    • Author(s)
      Kazuhiko Matsuda
    • Organizer
      APCHNE 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 殺線虫活性物質パラヘルクアミドの線虫選択的活性発現機構2019

    • Author(s)
      二木 邦浩、重藤 渉、嶋田 翔太、野口 晃、伊原 誠、松田 一彦
    • Organizer
      日本農芸化学会関西支部例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 天然殺線虫活性物質パラヘルクアミドに対する感受性を決定する標的構造2019

    • Author(s)
      二木 邦浩、重藤 渉、嶋田 翔太、野口 晃、伊原 誠、松田 一彦
    • Organizer
      日本ケミカルバイオロジー学会第14回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Toward understanding the mechanism of selectivity of neonicotinoids: Interactions with loop C and loop DEG triangle of Drosophila Dα1 subunit with imidacloprid and thiacloprid2019

    • Author(s)
      Kazuhiko Matsuda
    • Organizer
      Fall 2019 ACS National Meeting & Expo National Meeting and Exposition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 糸状菌が産生する殺線虫活性物質パラヘルクアミドに対する感受性 を決定する標的構造2019

    • Author(s)
      二木 邦浩、重藤 渉、嶋田 翔太、野口 晃、伊原 誠、松田一彦
    • Organizer
      日本農芸化学会関西・中部支部 2019年度合同神戸大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Viewing microbial products from a distinct angle2019

    • Author(s)
      Kazuhiko Matsuda
    • Organizer
      The 1st International Symposium on the Chemical Communications
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 糸状菌が生産するコムネシン類の殺虫活性発現に関わる標的と構造2019

    • Author(s)
      野口 晃、村田 和也、伊原 誠、甲斐 建次、林 英雄、松田 一彦
    • Organizer
      第44回日本農薬学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] コムネシン類と標的受容体の構造活性相関2019

    • Author(s)
      野口 晃、村田 和也、伊原 誠、甲斐 建次、林 英雄、松田 一彦
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 線虫ニコチン性アセチルコリン受容体のタイプ分類に関与する構造因子2019

    • Author(s)
      二木 邦浩、重藤 渉、嶋田 翔太、野口 晃、伊原 誠、松田 一彦
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ネオニコチノイドの選択毒性発現におけるLoop Cの役割2019

    • Author(s)
      嶋田 翔太、疋田 麻衣、重藤 渉、松本 祥太郎、谷河 純、伊原 誠、松田 一彦
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糸状菌Pleosporales sp. RKB3564の生産するpyrrolizilactone生合成経路の解析2019

    • Author(s)
      廣澤 早香、加藤 直樹、野川 俊彦、衣笠 清美、高橋 俊二、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 標的の活性化に関わるオカラミンの構造因子2018

    • Author(s)
      野口 晃、加藤 直樹、古谷 章悟、大高 潤之介、衣笠 清美、甲斐 建次、林 英雄、伊原 誠、高橋 俊二、長田 裕之、松田 一彦
    • Organizer
      第43回日本農薬学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ニコチン性アセチルコリン受容体に対するネオニコチノイドのアゴニスト活性における隣接αサブユニットの役割2018

    • Author(s)
      疋田 麻衣、奥原 大樹、伊原 誠、松田 一彦
    • Organizer
      第43回日本農薬学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Natural insecticides okaramines: Structure-activity relationship for activation of glutamate-gated chloride channels2018

    • Author(s)
      Akira Noguchi, Naoki Kato, Shogo Furutani, Junnosuke Otaka, Kiyomi Kinugasa, Kenji Kai, Hideo Hayashi, Makoto Ihara, Shunji Takahashi, Hiroyuki Osada and Kazuhiko Matsuda
    • Organizer
      Pyrethrum Workshop 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] A hidden mode of action of neonicotinoids2018

    • Author(s)
      Mai Hikida, Shota Shimada, Makoto Ihara and Kazuhiko Matsuda
    • Organizer
      Pyrethrum Workshop 2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] [4+2]環化付加反応におけるデカリン合成酵素Fsa2の機能解析2018

    • Author(s)
      加藤 直樹、野川 俊彦、滝田 良、衣笠 清美、金井 美紗衣、内山 真伸、長田 裕之、高橋 俊二
    • Organizer
      第60回天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 立体選択的[4+2]環化付加反応を担うFsa2ファミリーデカリン合成酵素の機能解析2018

    • Author(s)
      加藤 直樹
    • Organizer
      東京大学大学院薬学研究科天然物化学教室講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 昆虫グルタミン酸作動性塩素チャネルの多様性とインドールアルカロイドコムネシンの活性化作用2018

    • Author(s)
      野口晃、橋本杏樹、古谷章悟、奥原大樹、伊原誠、甲斐建次、林英雄、松田一彦
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ショウジョウバエニコチン性アセチルコリン受容体Dα1サブユニットのYXCCモチーフ構造とネオニ コチノイド感受性2018

    • Author(s)
      疋田麻衣、奥原大樹、伊原誠、松田一彦
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] カイコガpH感受性塩素チャネルの膜貫通領域欠損型バリアントの機能解析2018

    • Author(s)
      奥原大樹、野口晃、伊原誠、松田一彦
    • Organizer
      日本農芸化学会2018年度大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Loop D-E-G triangle in fruit fly Dα1 subunit contributes to high neonicotinoid sensitivity of Dα1-chicken β2 hybrid nicotinic acetylcholine receptor2017

    • Author(s)
      Matsuda Kazuhiko
    • Organizer
      2017 Nicotinic Acetylcholine Receptor
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Canonical and non-canonical binding sites of neonicotinoids determining their selective actions on insect nicotinic acetylcholine receptors2017

    • Author(s)
      Matsuda Kazuhiko
    • Organizer
      The 254th ACS National Meeting & Exposition
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Modulation of ligand-gated chloride channels by fungal metabolites produced in response to plant factors2017

    • Author(s)
      Matsuda Kazuhiko
    • Organizer
      33rd annual meeting of the International Society of Chemical Ecology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Function of allosamidin in environment2017

    • Author(s)
      Sakuda Shohei
    • Organizer
      4th China International and Cross-strait Chitin and Chitosan Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Elucidating the target of communesins, fungal metabolites acting as insecticides2017

    • Author(s)
      Noguchi Akira、Hashimoto Anju、Ihara Makoto、Kai Kenji、Hayashi Hideo、Matsuda Kazuhiko
    • Organizer
      33rd annual meeting of the International Society of Chemical Ecology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ivermectin modulation of the pH-sensitive chloride channel2017

    • Author(s)
      Okuhara Daiki、Furutani Shogo、Ito Katsuhiko、Ihara Makoto、Matsuda Kazuhiko
    • Organizer
      33rd annual meeting of the International Society of Chemical Ecology
    • Related Report
      2017 Annual Research Report
  • [Presentation] インドールアルカロイド・コムネシンの殺虫活性の原因を探る2017

    • Author(s)
      野口晃、古谷章悟、橋本杏樹、伊原誠、甲斐建次、林英雄、松田一彦
    • Organizer
      日本ケミカルバイオロジー学会 第12回年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 糸状菌が産生する殺虫性アルカロイド・コムネシンの活性発現に貢献する標的受容体の構造因子2017

    • Author(s)
      橋本杏樹、古谷章悟、野口晃、伊原誠, 甲斐建次、林英雄、松田一彦
    • Organizer
      日本農芸化学会 関西・中四国・西日本支部 2017年度合同大阪大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 昆虫-脊椎動物ハイブリッド型ニコチン性アセチルコリン受容体に2017

    • Author(s)
      疋田麻衣、伊原誠、松田一彦
    • Organizer
      日本農芸化学会 関西・中四国・西日本支部 2017年度合同大阪大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 殺線虫活性を示す糸状菌代謝物パラヘルクアミドの活性発現機構の構造生物学的理解2017

    • Author(s)
      伊原誠、野口晃、二木邦浩、古谷章悟、松田一彦
    • Organizer
      日本農芸化学会 関西・中四国・西日本支部 2017年度合同大阪大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] pH依存性塩素チャネルのイベルメクチン感受性決定因子の解明2017

    • Author(s)
      奥原大樹、古谷章悟、伊原誠、松田一彦
    • Organizer
      日本農芸化学会 関西・中四国・西日本支部 2017年度合同大阪大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Structure-activity relationship of indole alkaloids okaramines on insect glutamate-gated chloride channels2017

    • Author(s)
      Noguchi Akira、Furutani Shogo、Ihara Makoto、Kai Kenji、Hayashi Hideo、Otaka Junnosuke、Kinugasa Kiyomi、Kato Naoki、Takahashi Shunji、Osada Hiroyuki、Matsuda Kazuhiko
    • Organizer
      JSBBA KANSAI 4th Student Forum
    • Related Report
      2017 Annual Research Report
  • [Presentation] Ivermectin modulation of the pH-sensitive chloride channel2017

    • Author(s)
      Okuhara Daiki、Furutani Shogo、Makoto Ihara、Matsuda Kazuhiko
    • Organizer
      JSBBA KANSAI 4th Student Forum
    • Related Report
      2017 Annual Research Report
  • [Presentation] Contribution of loop D-E-G triangle to neonicotinoid sensitivity of insect-vertebrate hybrid nicotinic acetylcholine receptor2017

    • Author(s)
      Hikida Mai、Ihara Makoto、Matsuda Kazuhiko
    • Organizer
      JSBBA KANSAI 4th Student Forum
    • Related Report
      2017 Annual Research Report
  • [Remarks] This Week in PNAS

    • URL

      https://www.pnas.org/content/117/28/16087

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

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