| Budget Amount *help |
¥41,080,000 (Direct Cost: ¥31,600,000、Indirect Cost: ¥9,480,000)
Fiscal Year 2021: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2020: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2019: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2018: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
Synthetic studies on polycyclic natural products were carried out. An intramolecular 1,3-dipolar cycloaddition, followed by cleavage of the resulting skeleton, produced the characteristic lactam structure of huperzine R. Tetrodotoxin was synthesized by differentiating two aldehyde moieties by an intramolecular nucleophilic attack of a guanidine moiety. Haliclonin A was synthesized using ring closing metathesis to form macrocyclic rings. The [7-5-5] tricyclic system of Daphniphyllum alkaloids was constructed through an electrocyclic reaction of a pentadienyl cation, followed by a reaction of the resulting cyclopentenyl cation.
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