Glia-induced Remodeling of Neuronal Circuits
| Project/Area Number |
17H01530
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
JUNICHI NABEKURA 生理学研究所, 基盤神経科学研究領域, 所長 (50237583)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2018: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2017: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
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| Keywords | ミクログリア / 神経回路 / 再編成 / アストロサイト / シナプス / 神経回路再編 / 脳血管関門 / 慢性疼痛 / グリア / 大脳皮質 / 痛覚過敏 / ミラーイメージペイン / シナプス再編 / 神経細胞 / 細胞間相互作用 / in vivoイメージング / 2光子顕微鏡 |
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| Outline of Final Research Achievements |
Changes in functional neural circuits are the basis of brain function in development and disorders. In this study, we investigated the reorganization of the neural circuits in cerebral cortex of mice and the contribution of glial cells, using two-photon excitation microscope as the main research method. We demonstrated that resting microglia repeatedly contact onto synapses, promote synaptic transmission during their contact, leading to synchronous activity of local neural circuits in healthy brain, On the other hand, activated microglia lost their facilitatory action on synapse transmission. As for the role of astrocyte in circuits remodeling, reactivating astrocytes and controlling peripheral nerve activity in chronic pain model mice could alleviate hyperalgesia for a long period of time, caused by the removal of pain-related synapses. This result suggests that manipulation of glial cells may be a therapeutic strategy for pathological conditions.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性疼痛などの慢性脳疾患の治療法として、グリア細胞をターゲットとした新規治療戦略を提示した。
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels.2020
Author(s)
Aya Sato, Shiho Arichi, Fumiaki Kojima, Toru Hayashi, Tatsuko Ohba, Dennis Lawrence Cheung, Kei Eto, Madoka Narushima, Hideji Murakoshi, Yoshihiro Maruo, Yuichi Kadoya, Junichi Nabekura, Hitoshi Ishibashi.
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Journal Title
Eur J Pharmacol.
Volume: 886
Pages: 173536-173536
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Microglia Enhance Synapse Activity to Promote Local Network Synchronization2018
Author(s)
Ryohei Akiyoshi, Hiroaki Wake, Daisuke Kato, Hiroshi Horiuchi, Riho Ono, Ako Ikegami, Koichiro Haruwaka, Toshiaki Omori, Yoshihisa Tachibana, Andrew Moorhouse, Junichi Nabekura
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Journal Title
eNeuro
Volume: 5
Issue: 5
Pages: 0088-18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Astrocytes with previous chronic exposure to amyloid beta-peptide fragment 1–40 suppress excitatory synaptic transmission.2017
Author(s)
Kawano H, Oyabu K, Yamamoto H, Eto K, Adaniya Y, Kubota K, Watanabe T, Hirano-Iwata A, Nabekura J, Katsurabayasi S, Iwasaki K.
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Journal Title
J Neurochemistry
Volume: 143
Issue: 6
Pages: 624-634
DOI
Related Report
Peer Reviewed
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