| Budget Amount *help |
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2019: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2017: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Outline of Final Research Achievements |
The Golgi membrane-associated degradation pathway (GOMED) is a mechanism that degrades undelivered plasma membrane proteins and secretory proteins upon Golgi stress. GOMED is a unique and novel Golgi function involving dramatic morphological changes in the Golgi.
(1) We here identified five GOMED-associated molecules, and identified their signaling pathways. (2) We also clarified the role ofGOMED in neurons and pancreatic beta cells. (3) We developed the methods to detect GOMED using Ulk1 phosphorylation and small fluorescence compound. (4) We identified cytosolic accumulation of undelivered Golgi molecules, and which induces cell injury.
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