Biological roles of novel proteolytic mechanism GOMED
Project/Area Number |
17H01533
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General medical chemistry
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
shimizu shigeomi 東京医科歯科大学, 難治疾患研究所, 教授 (70271020)
|
Project Period (FY) |
2017-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥41,470,000 (Direct Cost: ¥31,900,000、Indirect Cost: ¥9,570,000)
Fiscal Year 2019: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2018: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2017: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
|
Keywords | GOMED / 新規オートファジー / ゴルジ体 / Atg5 / Ulk1 / オートファジー / RIPK3 / 生体分子 / シグナル伝達 / 細胞・組織 |
Outline of Final Research Achievements |
The Golgi membrane-associated degradation pathway (GOMED) is a mechanism that degrades undelivered plasma membrane proteins and secretory proteins upon Golgi stress. GOMED is a unique and novel Golgi function involving dramatic morphological changes in the Golgi. (1) We here identified five GOMED-associated molecules, and identified their signaling pathways. (2) We also clarified the role ofGOMED in neurons and pancreatic beta cells. (3) We developed the methods to detect GOMED using Ulk1 phosphorylation and small fluorescence compound. (4) We identified cytosolic accumulation of undelivered Golgi molecules, and which induces cell injury.
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Academic Significance and Societal Importance of the Research Achievements |
GOMED機能は、ホルモンやサイトカインなどの細胞外分泌や細胞膜レセプターの発現量を調節する機能として、我々が発見した新たな細胞機能です。本研究では、GOMED機構がどのようにして実行されるか、どの細胞で実行されるか、この機構が働かないと如何なる障害が起こるかを研究しました。その結果、神経細胞の維持やホルモン分泌制御に決定的な役割を果たしてることを発見しました。また、この機構の検出方法も明らかにし、今後病気への応用が期待されます。
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue.2020
Author(s)
Kato H, Okabe K, Miyake M, Hattori K, Fukaya T, Tanimoto K, Beini S, Mizuguchi M, Torii S, Arakawa S, Ono M, Saito Y, Sugiyama T, Funatsu T, Sato K, Shimizu S, Oyadomari S, Ichijo H, Kadowaki H, Nishitoh H.
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Journal Title
Life science alliance
Volume: 3
Issue: 3
Pages: 201900576-201900576
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sanguisorba officinalis L. derived from herbal medicine prevents intestinal inflammation by inducing autophagy in macrophages.2020
Author(s)
Yasueda A, Kayama H, Murohashi M, Nishimura J, Wakame K, Komatsu K, Ogino T, Miyoshi N, Takahashi H, Uemura M, Matsuda C, Kitagawa T, Takeda K, Ito T, Doki Y, Eguchi H, Shimizu S, Mizushima T
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Journal Title
Scientific reports
Volume: press
Related Report
Peer Reviewed
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