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Basic research on the immunohistological categorization of tumor microenvironment

Research Project

Project/Area Number 17H01540
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionSapporo Medical University

Principal Investigator

TORIGOE Toshihiko  札幌医科大学, 医学部, 教授 (20301400)

Co-Investigator(Kenkyū-buntansha) 橋本 真一  和歌山県立医科大学, 先端医学研究所, 教授 (00313099)
廣橋 良彦  札幌医科大学, 医学部, 准教授 (30516901)
塚原 智英  札幌医科大学, 医学部, 准教授 (20404634)
金関 貴幸  札幌医科大学, 医学部, 講師 (50531266)
久保 輝文  札幌医科大学, 医学部, 助教 (90580019)
中津川 宗秀  札幌医科大学, 医学部, 助教 (70448596)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2018: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2017: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Keywords腫瘍微小環境 / T細胞抗原受容体 / がん免疫療法 / 免疫組織染色 / バイオマーカー / がん最適化治療 / 単細胞遺伝子解析 / がん幹細胞 / がん組織微小環境 / がん免疫応答 / 単細胞遺伝子発現解析 / 免疫病理バイオマーカー / Tumor microenvironment / Cancer stem cell / Single cell analysis / Tumor immune escape / Immune response / Immunohistochemistry / 腫瘍免疫 / 免疫病理診断 / Tumor antigen / 病理学 / 腫瘍学 / 免疫学 / 分子生物学 / 細胞・組織
Outline of Final Research Achievements

Tumor microenvironment (TME) was categorized into three classes by using tissue single cell analysis and multiplex immunohistochemistry (IHC) of primary human cancer tissues. It was revealed that seven IHC biomarkers were suitable for the TME classification, which could become the predictive marker for immune checkpoint blockade therapy as well as patients’ prognosis. In addition, clonality of T-cell antigen receptors and their target antigens were analyzed in primary cancer tissues. It was found that there was a close correlation between TME classification and T-cell clonality. We proposed a novel diagnostic tool that should contribute to the precision therapy of cancer.

Academic Significance and Societal Importance of the Research Achievements

本研究で最大の学術的意義は、1細胞レベルで遺伝子発現の多様性を分析する組織単細胞遺伝子解析技術によって腫瘍微小環境(TME)の多様性を類型化し、免疫組織染色と融合した初めての研究である点にある。
2つめの意義は、多重免疫組織染色によってTMEを分類し、がん個性診断に応用した点である。一般的な検査施設で簡便かつ迅速にがん個性を検査することが可能であることを証明した。
3つめの意義は、本研究成果のがん最適化治療への貢献にある。がんの治療抵抗性の原因は腫瘍微小環境の多様性にあるが、本研究はこれを類型化し、がん個性診断を治療法選択のバイオマーカーとしたことに意義がある。

Report

(3 results)
  • 2019 Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(79 results)

All 2019 2018 2017 Other

All Int'l Joint Research Journal Article Presentation Book Remarks Patent(Industrial Property Rights)

  • [Int'l Joint Research] INSERM/Université Paris Descartes/Université Pierre et Marie Curie(フランス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Mayo Clinic/Providence Portland Medical Center(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Bern/University Hospital of Bern(スイス)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Radboud University(オランダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University Erlangen-Nurnberg(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] INSERM/University of Paris Descartes/University of Pierre et Marie Curie(フランス)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Mayo Clinic/Providence Portland Medical Center/Oregon Health and Science University(USA)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Toronto/Princess Margaret Cancer Centre/Ontario Cancer Institute(Canada)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Istituto Nazionale per lo Studio/University Hospital of Siena/Humanitas Clinical and Research Center(Italy)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Erlangen(Germany)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma2019

    • Author(s)
      Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
    • Journal Title

      Experimental and Molecular Pathology

      Volume: 106 Pages: 78-88

    • DOI

      10.1016/j.yexmp.2018.11.013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma.2019

    • Author(s)
      Kubo Terufumi、Tsujiwaki Mitsuhiro、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Nakatsugawa Munehide、Hasegawa Tadashi、Torigoe Toshihiko
    • Journal Title

      Laboratory Investigation

      Volume: 99 Pages: 158-168

    • DOI

      10.1038/s41374-018-0132-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel human leukocyte antigen‐A*11:01‐restricted cytotoxic T‐lymphocyte epitopes derived from osteosarcoma antigen papillomavirus binding factor2019

    • Author(s)
      Li Dongliang、Toji Shingo、Watanabe Kazue、Torigoe Toshihiko、Tsukahara Tomohide
    • Journal Title

      Cancer Science

      Volume: 110 Pages: 1156-1168

    • DOI

      10.1111/cas.13973

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of PD-L1 expression in immune cells on the response to radiation therapy in patients with oropharyngeal squamous cell carcinoma.2018

    • Author(s)
      Fukushima Yuki、Someya Masanori、Nakata Kensei、Hori Masakazu、Kitagawa Mio、Hasegawa Tomokazu、Tsuchiya Takaaki、Gocho Toshio、Ikeda Hikaru、Hirohashi Yoshihiko、Torigoe Toshihiko、Sugita Shintaro、Hasegawa Tadashi、Himi Tetsuo、Sakata Koh-ichi
    • Journal Title

      Radiotherapy and Oncology

      Volume: 129 Pages: 409-414

    • DOI

      10.1016/j.radonc.2018.08.023

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells2018

    • Author(s)
      Watanabe Kazue、Tsukahara Tomohide、Toji Shingo、Saitoh Shogo、Hirohashi Yoshihiko、Nakatsugawa Munehide、Kubo Terufumi、Kanaseki Takayuki、Kameshima Hidekazu、Terui Takeshi、Sato Noriyuki、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 110 Pages: 40-51

    • DOI

      10.1111/cas.13854

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study2018

    • Author(s)
      Pages F, Mlecnik B, Xu M, Kawakami Y, Galon J, et al.
    • Journal Title

      The Lancet

      Volume: 391(10135) Pages: 2128-2139

    • DOI

      10.1016/s0140-6736(18)30789-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rechallenge With Nivolumab After Vemurafenib Treatment of Initially Nivolumab-Resistant Advanced Melanoma2018

    • Author(s)
      Kato Junji、Hida Tokimasa、Kamiya Takafumi、Sato Sayuri、Takahashi Hitomi、Torigoe Toshihiko、Uhara Hisashi
    • Journal Title

      JAMA Dermatology

      Volume: 154 Pages: 621-621

    • DOI

      10.1001/jamadermatol.2017.6400

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 12018

    • Author(s)
      Kusumoto Hiroki、Hirohashi Yoshihiko、Nishizawa Satoshi、Yamashita Masamichi、Yasuda Kazuyo、Murai Aiko、Takaya Akari、Mori Takashi、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Kondo Toru、Sato Noriyuki、Hara Isao、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 741-750

    • DOI

      10.1111/cas.13501

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of HPV genotyping and cytology triage, COMPACT-Study: Design, methods and baseline results in 14,642 women2018

    • Author(s)
      Aoyama-Kikawa Satomi、Fujita Hiromasa、Hanley Sharon J.B.、Kasamo Mitsunori、Kikuchi Kokichi、Torigoe Toshihiko、Matsuno Yoshihiro、Tamakoshi Akiko、Sasaki Takayuki、Matsuura Motoki、Kato Yasuhito、Dong Peixin、Watari Hidemichi、Saito Tsuyoshi、Sengoku Kazuo、Sakuragi Noriaki
    • Journal Title

      Cancer Sci

      Volume: 109 Pages: 2003-12

    • DOI

      10.1111/cas.13608

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer2018

    • Author(s)
      Miyamoto Sho、Kochin Vitaly、Kanaseki Takayuki、Hongo Ayumi、Tokita Serina、Kikuchi Yasuhiro、Takaya Akari、Hirohashi Yoshihiko、Tsukahara Tomohide、Terui Takeshi、Ishitani Kunihiko、Hata Fumitake、Takemasa Ichiro、Miyazaki Akihiro、Hiratsuka Hiroyoshi、Sato Noriyuki、Torigoe Toshihiko
    • Journal Title

      Cancer Immunology Research

      Volume: 6 Pages: 358-369

    • DOI

      10.1158/2326-6066.cir-17-0518

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case report: Long-term survival of a pancreatic cancer patient immunized with an SVN-2B peptide vaccine2018

    • Author(s)
      Shima H, Kutomi G, Satomi F, Imamura M, Kimura Y, Mizuguchi T, Watanabe K, Takahashi A, Murai A, Tsukahara T, Kanaseki T, Hirohashi Y, Iwayama Y, Tsuruma T, Kameshima H, Sato N, Torigoe T, Takemasa I.
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 67 Pages: 1603-1609

    • DOI

      10.1007/s00262-018-2217-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B42018

    • Author(s)
      Nosaka T, Baba T, Tanabe Y, Sasaki S, Nishimura T, Imamura Y, Yurino H, Hashimoto S, Arita M, Nakamoto Y, Mukaida N.
    • Journal Title

      J Immunol.

      Volume: 200 Pages: 1839-1852

    • DOI

      10.4049/jimmunol.1700544

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy2017

    • Author(s)
      Ohno Y, Toyoshima Y, Yurino H, Monma N, Xiang H, Sumida K, Kaneumi S, Terada S, Hashimoto S, Ikeo K, Homma S, Kawamura H, Takahashi N, Taketomi A, Kitamura H
    • Journal Title

      Cancer Sci.

      Volume: 108 Pages: 1959-1666

    • DOI

      10.1111/cas.13330

    • NAID

      120006365330

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive single-cell transcriptome analysis reveals heterogeneity in endometrioid adenocarcinoma tissues2017

    • Author(s)
      Hashimoto S, Tabuchi Y, Yurino H, Hirohashi Y, Deshimaru S, Asano T, Mariya T, Oshima K, Takamura Y, Ukita Y, Ametani A, Kondo N, Monma N, Takeda T, Misu S, Okayama T, Ikeo K, Saito T, Kaneko S, Suzuki Y, Hattori M, Matsushima K, et al.
    • Journal Title

      Scientific Rep.

      Volume: 7 Pages: 14225-14225

    • DOI

      10.1038/s41598-017-14676-3

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy2017

    • Author(s)
      Horibe, R. Hirohashi, Y. Asano, T. Mariya, T. Suzuki, T. Takaya, A. Saijo, H. Shionoya, Y. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Watanabe, K. Atsuyama, E. Toji, S. Hirano, H. Hasegawa, T. Takahashi, H. Sato, N. Torigoe, T.
    • Journal Title

      PLoS One

      Volume: 12 Pages: 0171460-0171460

    • DOI

      10.1371/journal.pone.0171460

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis2017

    • Author(s)
      Inoue Ryuta、Hirohashi Yoshihiko、Kitamura Hiroshi、Nishida Sachiyo、Murai Aiko、Takaya Akari、Yamamoto Eri、Matsuki Masahiro、Tanaka Toshiaki、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Sato Noriyuki、Masumori Naoya、Torigoe Toshihiko
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 28826-28839

    • DOI

      10.18632/oncotarget.16259

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses2017

    • Author(s)
      Kochin V, Kanaseki T, Tokita S, Miyamoto S, Shionoya Yo, Kikuchi Y, Morooka D, Hirohashi Y, Tsukahara T, Watanabe K, Toji S, Kokai Y, Sato N, Torigoe T.
    • Journal Title

      Oncoimmunology

      Volume: 6 Pages: 1-12

    • DOI

      10.1080/2162402x.2017.1293214

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon2017

    • Author(s)
      Kubo, T. Hirohashi, Y. Matsuo, K. Sonoda, T. Sakamoto, H. Furumura, K. Tsukahara, T. Kanaseki, T. Nakatsugawa, M. Hirano, H. Furuhata, T. Takemasa, I. Hasegawa, T. Torigoe, T.
    • Journal Title

      Anticancer Res

      Volume: 37 Pages: 1289-1295

    • DOI

      10.21873/anticanres.11446

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of cancer-stem cell antigens and development of CTL-mediated cancer immunotherapy2017

    • Author(s)
      Miyamoto, S. Kanaseki, T. Hirohashi, Y. Tsukahara, T. Kikuchi, Y. Sato, N. Torigoe, T.
    • Journal Title

      Japanese Journal of Clinical Immunology

      Volume: 40 Issue: 1 Pages: 40-47

    • DOI

      10.2177/jsci.40.40

    • NAID

      130005665568

    • ISSN
      0911-4300, 1349-7413
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Identification of antigenic peptides from novel renal cancer stem-like cell antigen, DNAJB8.2017

    • Author(s)
      Nishizawa S, Hirohashi Y, Kusumoto H, Wakamiya T, Iguchi T, Yamashita S, Iba A, Kikkawa K, Kohjimoto Y, Torigoe T, Hara I
    • Journal Title

      Biochemical Biophysical Research Communication

      Volume: 494 Pages: 693-699

    • DOI

      10.1016/j.bbrc.2017.10.146

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma2017

    • Author(s)
      Okamoto, J. Y. Miyazaki, A. Kobayashi, J. I. Miyamoto, S. Sasaki, T. Kanaseki, T. Hirohashi, Y. Torigoe, T. Hiratsuka, H.
    • Journal Title

      Anticancer Res

      Volume: 37 Pages: 4889-4897

    • DOI

      10.21873/anticanres.11898

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy2017

    • Author(s)
      Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
    • Journal Title

      Cancer Sci

      Volume: 108 Pages: 1739-1745

    • DOI

      10.1111/cas.13319

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition2017

    • Author(s)
      Yosuke Shionoya, Takayuki Kanaseki, Sho Miyamoto, et al.
    • Journal Title

      Oncoimmunology

      Volume: 6 Pages: 1274476-1274476

    • DOI

      10.1080/2162402x.2016.1274476

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Immune-related adverse events of immune checkpoint inhibitors2017

    • Author(s)
      Tadano, H. Torigoe, T.
    • Journal Title

      Japanese Journal of Clinical Immunology

      Volume: 40 Issue: 2 Pages: 102-108

    • DOI

      10.2177/jsci.40.102

    • NAID

      130005696886

    • ISSN
      0911-4300, 1349-7413
    • Related Report
      2017 Annual Research Report
  • [Journal Article] Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells2017

    • Author(s)
      Takeda, R. Hirohashi, Y. Shen, M. Wang, L. Ogawa, T. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 485 Pages: 651-657

    • DOI

      10.1016/j.bbrc.2017.02.081

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer-associated oxidoreductase ERO1-alpha promotes immune escape through up-regulation of PD-L1 in human breast cancer2017

    • Author(s)
      Tanaka T, Kutomi G, Kajiwara T, Kukita K, Kochin V, Kanaseki T, Tsukahara T, Hirohashi Y, Torigoe T, Okamoto Y, Hirata K, Sato N, Tamura Y.
    • Journal Title

      Oncotarget

      Volume: 2016 Pages: 24706-24718

    • DOI

      10.18632/oncotarget.14960

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells2017

    • Author(s)
      Wang, L. Hirohashi, Y. Ogawa, T. Shen, M. Takeda, R. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 486 Pages: 232-238

    • DOI

      10.1016/j.bbrc.2017.02.112

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP272017

    • Author(s)
      Yasuda, K. Hirohashi, Y. Mariya, T. Murai, A. Tabuchi, Y. Kuroda, T. Kusumoto, H. Takaya, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Tamura, Y. Hirano, H. Hasegawa, T. Saito, T. Sato, N. Torigoe, T.
    • Journal Title

      Oncotarget

      Volume: 8 Pages: 31540-31553

    • DOI

      10.18632/oncotarget.16361

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cancer stem cell-targeted immunotherapeutic strategy:cancer stem antigens and fibroblastic niche2019

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research:Biology to Precision Medicine
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-cell transcriptome analysis reveals the gene exchange of cancer cells with high malignant potential and immune cells in endometrioid adenocarcinoma tissues.2019

    • Author(s)
      Hashimoto S.
    • Organizer
      Single cell biology meets diagnostics workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん免疫研究の最前線と免疫療法の展望2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第107回日本病理学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 組織レベルにおけるがん免疫応答解析2018

    • Author(s)
      廣橋 良彦
    • Organizer
      第59回日本組織細胞化学会総会・学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がん微小環境における1細胞遺伝子発現解析2018

    • Author(s)
      橋本真一
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] ingle-cell transcriptome analysis reveals the gene exchange of cancer cells with high malignant potential and immune cells.2018

    • Author(s)
      Hashimoto S, Tabuchi Y, Torigoe T, Iwabuchi S.
    • Organizer
      ASHG 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Single-cell gene expression analysis in gynecological cancer.2018

    • Author(s)
      Hashimoto S.
    • Organizer
      HCA Asia Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Landscape of natural HLA class I ligand peptides of cancer cells2018

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      The 45th Naito Conference
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Novel immunotherapeutic strategy based on the immunopathological properties of cancer stem cells2018

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      The 4th CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プロテオゲノミクスがもたらした腫瘍免疫の新展開2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第46回日本臨床免疫学会総会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Ovarian cancer stem cells are maintained by fibroblastic niche and have constitutively active stress-response signaling2018

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      5th International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 免疫チェックポイント阻害剤の免疫学的基盤2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第91回日本内分泌学会ワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 進行膵がんに対するがん免疫療法2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第49回日本膵臓学会シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 複合がん免疫療法の病理と臨床:腫瘍免疫病理学の視点から2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第22回日本がん免疫学会総会ランチョンセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] がん幹細胞と免疫システム:免疫系はがん幹細胞を識別できるか?2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第15回日本病理学会カンファレンス
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 複合がん免疫療法のコンセプト2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第56回日本癌治療学会スポンサードシンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 免疫病理学から総括する免疫チェックポイント阻害剤の自己免疫副作用2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第33回日本臨床リウマチ学会特別企画
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 肉腫の免疫療法は可能か?2018

    • Author(s)
      鳥越 俊彦
    • Organizer
      第3回日本肉腫学会・日本臨床肉腫学会合同年次総会学術シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] CTL responses against a cancer-stem cell specific antigen, ASB4, effectively prevent colorectal cancer formation2017

    • Author(s)
      Kanaseki T, Miyamoto S, Tokita S, Torigoe T.
    • Organizer
      THIRD CRI-CIM-EATI-AACR International Cancer Immunotherapy Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular Mechanism of Cancer Cell Hormesis2017

    • Author(s)
      鳥越俊彦、廣橋良彦
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Phosphorylation of HSF1 at Ser326 residue is associated with the maintenance of gynecologic cancer stem cells.2017

    • Author(s)
      Toshihiko Torigoe, Yoshihiko Hirohashi, Kazuyo Yasuda, Aiko Murai, Tsuyoshi Saito, Noriyuki Sato
    • Organizer
      The Eighth International Congress on Stress Proteins in Biology and Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 病理学を基盤としたがん免疫療法研究2017

    • Author(s)
      鳥越俊彦
    • Organizer
      日本癌学会2017ランチョンセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Basic methodology for immuno-oncology research2017

    • Author(s)
      鳥越俊彦
    • Organizer
      日本癌学会2017 モーニングレクチャー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 免疫チェックポイント阻害薬の光と影:自己免疫炎症性副作用について2017

    • Author(s)
      鳥越俊彦
    • Organizer
      日本臨床免疫学会2017 アニュアルエビデンスレビュー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A harmonized evaluation system for expression of HLA class I antigens in formalin-fixed paraffin embedded cancer tissues2017

    • Author(s)
      Toshihiko Torigoe, Naoya Nakamura, Eri Atsuyama, Shingo Toji, Yuji Heike, Nobuyoshi Hiraoka
    • Organizer
      The Society for Immunotherapy of Cancer's (SITC) 32nd Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腫瘍免疫病理学の基礎と臨床 up-to-date2017

    • Author(s)
      鳥越俊彦
    • Organizer
      日本免疫学会2017 ランチョンセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Landscape of HLA class I ligand peptides2017

    • Author(s)
      Takayuki Kanaseki
    • Organizer
      The 36th Sapporo International Cancer Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Immunothrapeutic strategy targeting cancer-stem cells2017

    • Author(s)
      Yoshihiko Hirohashi
    • Organizer
      The 36th Sapporo International Cancer Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A novel population of stem-like memory T-cells2017

    • Author(s)
      Tomohide Tsukahara
    • Organizer
      The 36th Sapporo International Cancer Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Landscape of natural HLA ligand peptides2017

    • Author(s)
      Toshihiko Torigoe, Takayuki Kanaseki, Kochin Vitaly
    • Organizer
      第21回日本がん免疫学会総会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Single cell transcriptome analysis for dissecting tumor microenvironment2017

    • Author(s)
      Toshihiko Torigoe
    • Organizer
      The 32nd Nagoya International Cancer Treatment Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] がん免疫療法の基礎と臨床2017

    • Author(s)
      鳥越俊彦
    • Organizer
      第29回北海道癌治療研究会特別講演
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] がん免疫の分子病理学2017

    • Author(s)
      鳥越俊彦
    • Organizer
      第106回日本病理学会総会分子病理診断講習会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 免疫チェックポイント阻害剤最新知見2017

    • Author(s)
      鳥越俊彦
    • Organizer
      第11回日本緩和医療薬学会年会メディカルセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 新たな時代を迎えたがん免疫療法2017

    • Author(s)
      鳥越俊彦
    • Organizer
      第71回日本交通医学会総会ランテョンセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] がん免疫療法 Cancer Immunotherapy2017

    • Author(s)
      上田龍三、鵜殿平一郎、河上裕、鳥越俊彦、西川博嘉
    • Total Pages
      72
    • Publisher
      メディカルレビュー社
    • Related Report
      2017 Annual Research Report
  • [Book] 次世代がん治療2017

    • Author(s)
      塚原智英、鳥越俊彦
    • Total Pages
      386
    • Publisher
      (株)エヌ・ティー・エス
    • Related Report
      2017 Annual Research Report
  • [Remarks] 札幌医科大学医学部病理学第一講座<研究Research>

    • URL

      http://web.sapmed.ac.jp/patho1/research/index.html

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] がん幹細胞特異的抗体2018

    • Inventor(s)
      鳥越俊彦、塚原智英
    • Industrial Property Rights Holder
      鳥越俊彦、塚原智英
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-189834
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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