metabomic analysis of mitochondria-ralted diseases

• Project/Area Number: 17H01550
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kyushu University
• Principal Investigator: Kang Dongchon 九州大学, 医学研究院, 教授 (80214716)
• Co-Investigator(Kenkyū-buntansha): 内海 健 九州大学, 医学研究院, 教授 (80253798)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥41,860,000 (Direct Cost: ¥32,200,000、Indirect Cost: ¥9,660,000); Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2018: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2017: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
• Keywords: ミトコンドリア / p32 / IL6 / 免疫樹状細胞 / 心不全 / 拡張性心筋症 / NAD+ / リソソーム / ｐ32 / メタボローム / 乾癬 / ミトコンドリア病 / TFAM / 発癌 / 免疫応答 / 自然免疫 / 癌幹細胞 / 癌 / 老化

Outline of Final Research Achievements

(1) Intra-mitochondria specific metabolomics analysis: the systems were made for metabolomics assay for more than 1000 metabolites and rapid isolation of intact mitochondria.
(2) Prevention and treatment of mitochondria-related disease: (i) p32 is a mitochondria localized protein and critical for mitochondrial ATP production. We have found p32 adequately regulates LPS-induced IL6 production via AT4-intgarated stress response axis and maintains immune dendritic cell function by keeping citrate dehydrogenase active. (ii) Cardiomyocyte-specific KO of p32 gene induced dilated cardiomyopathy and cardiac failure. Its mechanism is not a general decline of cellular ATP level but a decrease in ATP production localized on lysosome membranes caused by reduced mitochondrial NAD+ production, which leads to less acidification of intra-lysosomes and impairs autophagic quality control of mitochondria. These results suggest a new mechanism for cardiac myopathy and raise a new target for its treatment.

Academic Significance and Societal Importance of the Research Achievements

今回の研究はミトコンドリア翻訳に極めて重要なタンパク質であるp32遺伝子のKOマウスの研究を通じて、ミトコンドリアによる自然免疫および獲得免疫機能の新しい制御機序を明らかにした。社会的に大きな問題となっている免疫異常による様々な疾患に対する新しい予防治療標的を提供するものである。また、心筋特異的p32遺伝子KOによる拡張性心筋症と引き続く心不全の発症機序に細胞内全体のATPではなくリソソーム膜上に限定したATP産生が重要であるという予想外の新しい視点を提供するとともに、NAD+と言う新しい治療標的を提示した。

Research Products

• [Int'l Joint Research] RC for Obst, Gynecol, Perinatol(ロシア連邦)
• [Journal Article] Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum (2019)
  • Author(s): Honsho Masanori、Dorninger Fabian、Abe Yuichi、Setoyama Daiki、Ohgi Ryohei、Uchiumi Takeshi、Kang Dongchon、Berger Johannes、Fujiki Yukio
  • Journal Title: The Journal of Biochemistry Volume: 166 Issue: 4 Pages: 353-361
  • DOI: 10.1093/jb/mvz043
  • NAID: 40022023663
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Protein C and protein S deficiencies may be related to survival among hemodialysis patients (2019)
  • Author(s): Ichinose Mayuri、Sasagawa Naru、Chiba Tetsuo、Toyama Katsuhide、Kayamori Yuzo、Kang Dongchon
  • Journal Title: BMC Nephrology Volume: 20 Issue: 1 Pages: 191-191
  • DOI: 10.1186/s12882-019-1344-8
  • Peer Reviewed
• [Journal Article] Development and validation of the 22-item Tarumi's modern-type depression trait scale; Avoidance of social roles, Complaint and low Self-esteem (TACS-22) (2019)
  • Author(s): Kato TA, Katsuki R, Kubo H, Shimokawa N, Sato-Kasai M, Hayakawa K, Kuwano N, Umene-akano W, Tateno M, Setoyama D, Kang D, Watabe M, Sakamoto S, Teo AR, Kanba S
  • Journal Title: Psychiatry and clinical neurosciences Volume: in press Issue: 8 Pages: 448-457
  • DOI: 10.1111/pcn.12842
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure (2019)
  • Author(s): Maekawa Satoshi、Takada Shingo、Nambu Hideo、Furihata Takaaki、Kakutani Naoya、Setoyama Daiki、Ueyanagi Yasushi、Kang Dongchon、Sabe Hisataka、Kinugawa Shintaro
  • Journal Title: Cell Communication and Signaling Volume: 17 Issue: 1 Pages: 128-128
  • DOI: 10.1186/s12964-019-0445-0
  • Peer Reviewed / Open Access
• [Journal Article] High genetic stability in MDCK-SIAT1 passaged human influenza viruses. (2019)
  • Author(s): Matsumoto, S., Chong, Y., Kang, D. and Ikematsu, H
  • Journal Title: J Infect Chemother Volume: 25 Issue: 3 Pages: 222-224
  • DOI: 10.1016/j.jiac.2018.08.012
  • Peer Reviewed
• [Journal Article] Recommended configuration for personal health records by standardized data item sets for diabetes mellitus and associated chronic diseases: a report from a collaborative initiative by six Japanese associations (2019)
  • Author(s): Nakashima Naoki、Noda Mitsuhiko、Ueki Kohjiro、Koga Tatsuhiko、Hayashi Michio、Yamazaki Katsuya、Nakagami Tomoko、Ohara Makoto、Gochi Akira、Matsumura Yasushi、Kimura Michio、Ohe Kazuhiko、Kang Dongchon、Toya Yoshiyuki、Yamagata Kunihiro、Yokote Koutaro、Ikeda Shunya、Mitsutake Naohiro、Yamamoto Ryuichi、Tanizawa Yukio
  • Journal Title: Diabetology International Volume: 10 Issue: 2 Pages: 85-92
  • DOI: 10.1007/s13340-019-00389-7
  • Peer Reviewed
• [Journal Article] Recommended configuration for personal health records by standardized data item sets for diabetes mellitus and associated chronic diseases: A report from Collaborative Initiative by six Japanese Associations (2019)
  • Author(s): Nakashima Naoki、Noda Mitsuhiko、Ueki Kohjiro、Koga Tatsuhiko、Hayashi Michio、Yamazaki Katsuya、Nakagami Tomoko、Ohara Makoto、Gochi Akira、Matsumura Yasushi、Kimura Michio、Ohe Kazuhiko、Kang Dongchon、Toya Yoshiyuki、Yamagata Kunihiro、Yokote Koutaro、Ikeda Shunya、Mitsutake Naohiro、Yamamoto Ryuichi、Tanizawa Yukio
  • Journal Title: Journal of Diabetes Investigation Volume: 10 Issue: 3 Pages: 868-875
  • DOI: 10.1111/jdi.13043
  • Peer Reviewed
• [Journal Article] Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies (2019)
  • Author(s): Suzuki H, Ohgidani M, Kuwano N, Chrétien F, Lorin de la Grandmaison G, Onaya M, Tominaga I, Setoyama D, Kang D, Mimura M, Kanba S, Kato TA*
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 13 Pages: 31-31
  • DOI: 10.3389/fncel.2019.00031
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan (2019)
  • Author(s): Chong, Y., Matsumoto, S., Kang, D., Ikematsu, H.
  • Journal Title: Influenza Other Respir Viruses Volume: 13 Issue: 2 Pages: 115-122
  • DOI: 10.1111/irv.12624
  • Peer Reviewed
• [Journal Article] Diagnostic challenge of the newborn patients with heritable protein C deficiency. (2019)
  • Author(s): chiyama, M., Inoue, H., Ochiai, M., Ishimura, M., Shiraishi, A., Fujiyoshi, J., Yamashita, H., Sato, K., Matsumoto, S., Hotta, T., Uchiumi, T., Kang, D. and Ohga,
  • Journal Title: J Perinatol Volume: 39 Issue: 2 Pages: 212-219
  • DOI: 10.1038/s41372-018-0262-0
  • Peer Reviewed
• [Journal Article] Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry. (2018)
  • Author(s): Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T.
  • Journal Title: Diabetes Care. Volume: 41 Issue: 5 Pages: 1061-1067
  • DOI: 10.2337/dc17-2004
  • Peer Reviewed
• [Journal Article] Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection, (2018)
  • Author(s): Okuzono, S., Ishimura, M., Kanno, S., Sonoda, M., Kaku, N., Motomura, Y., Nishio, H., Oba, U., Hanada, M., Fukushi, J. I., Urata, M., Kang, D., Takada, H., Ohga, S.
  • Journal Title: Ann Clin Microbiol Antimicrob Volume: 17 Issue: 1 Pages: 31-31
  • DOI: 10.1186/s12941-018-0282-9
  • Peer Reviewed
• [Journal Article] Slow Elevation in Protein C Activity without a PROC Mutation in a Neonate with Intracranial Hemorrhage. (2018)
  • Author(s): Uehara E, Nakao H, Tsumura Y, Nakadate H, Amari S, Fujinaga H, Tsutsumi Y, Kang D, Ohga S, Ishiguro A.
  • Journal Title: AJP Rep. Volume: 8 Issue: 02 Pages: e68-e70
  • DOI: 10.1055/s-0038-1639614
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation (2018)
  • Author(s): Gotoh Kazuhito、Morisaki Takafumi、Setoyama Daiki、Sasaki Katsuhiko、Yagi Mikako、Igami Ko、Mizuguchi Soichi、Uchiumi Takeshi、Fukui Yoshinori、Kang Dongchon
  • Journal Title: Cell Reports Volume: 25 Issue: 7 Pages: 1800-1815
  • DOI: 10.1016/j.celrep.2018.10.057
  • Peer Reviewed / Open Access
• [Journal Article] Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naive patients with major depressive disorder: an exploratory pilot case-control study. (2018)
  • Author(s): Kuwano N, Kato TA, Setoyama D, Sato-Kasai M, Shimokawa N, Hayakawa K, Ohgidani M, Sagata N, Kubo H, Kishimoto J, Kang D, Kanba S
  • Journal Title: Journal of Affective Disorders Volume: 231 Pages: 74-82
  • DOI: 10.1016/j.jad.2018.01.014
  • Peer Reviewed
• [Journal Article] Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA (2018)
  • Author(s): Matsuda, S., *Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotoh, K., Fukuda, K., Sasaki, H., Suzuki, T. and Kang, D.
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 5801-5801
  • DOI: 10.1038/s41598-018-24251-z
  • Peer Reviewed / Open Access
• [Journal Article] Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report (2017)
  • Author(s): Mezuki Satomi、Fukuda Kenji、Matsushita Tomonaga、Fukushima Yoshihisa、Matsuo Ryu、Goto Yu-ichi、Yasukawa Takehiro、Uchiumi Takeshi、Kang Dongchon、Kitazono Takanari、Ago Tetsuro
  • Journal Title: BMC Neurology Volume: 17 Issue: 1
  • DOI: 10.1186/s12883-017-1001-4
  • Peer Reviewed / Open Access
• [Journal Article] Doxycycline induces apoptosis via ER stress selectively to cells with a cancer stem cell-like properties: importance of stem cell plasticity (2017)
  • Author(s): Matsumoto Takashi、Uchiumi Takeshi、Monji Keisuke、Yagi Mikako、Setoyama Daiki、Amamoto Rie、Matsushima Yuichi、Shiota Masaki、Eto Masatoshi、Kang Dongchon
  • Journal Title: Oncogenesis Volume: 6 Issue: 11 Pages: 1-11
  • DOI: 10.1038/s41389-017-0009-3
  • Peer Reviewed / Open Access
• [Journal Article] Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration (2017)
  • Author(s): Yagi Mikako、Uchiumi Takeshi、Sagata Noriaki、Setoyama Daiki、Amamoto Rie、Matsushima Yuichi、Kang Dongchon
  • Journal Title: Scientific Reports Volume: 7 Issue: 1
  • DOI: 10.1038/s41598-017-15414-5
  • Peer Reviewed / Open Access
• [Journal Article] Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species (2017)
  • Author(s): Fakruddin Md.、Wei Fan Yan、Emura Shohei、Matsuda Shigeru、Yasukawa Takehiro、Kang Dongchon、Tomizawa Kazuhito
  • Journal Title: Nucleic Acids Research Volume: 45 Issue: 20 Pages: 11954-11961
  • DOI: 10.1093/nar/gkx819
  • Peer Reviewed / Open Access
• [Journal Article] Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies (2017)
  • Author(s): Feichtinger RG, Olahova M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H et al
  • Journal Title: The American Journal of Human Genetics Volume: 101 Issue: 4 Pages: 525-538
  • DOI: 10.1016/j.ajhg.2017.08.015
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation (2017)
  • Author(s): Matsushima Yuichi、Hirofuji Yuta、Aihara Masamune、Yue Song、Uchiumi Takeshi、Kaguni Laurie S.、Kang Dongchon
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 1-14
  • DOI: 10.1038/s41598-017-08088-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum adiponectin predicts fracture risk in individuals with type 2 diabetes: the Fukuoka Diabetes Registry (2017)
  • Author(s): Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T
  • Journal Title: Diabetologia Volume: 10 Issue: 10 Pages: 1922-1930
  • DOI: 10.1007/s00125-017-4369-1
  • Peer Reviewed
• [Journal Article] p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock (2017)
  • Author(s): Sasaki Katsuhiko、Gotoh Kazuhito、Miake Sho、Setoyama Daiki、Yagi Mikako、Igami Ko、Uchiumi Takeshi、Kang Dongchon
  • Journal Title: EBioMedicine Volume: 20 Pages: 161-172
  • DOI: 10.1016/j.ebiom.2017.05.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses (2017)
  • Author(s): Saito Toshiro、Uchiumi Takeshi、Yagi Mikako、Amamoto Rie、Setoyama Daiki、Matsushima Yuichi、Kang Dongchon
  • Journal Title: Cardiovascular Research Volume: 113 Issue: 10 Pages: 1173-1185
  • DOI: 10.1093/cvr/cvx095
  • Peer Reviewed / Open Access
• [Journal Article] Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK1 (2017)
  • Author(s): Tajiri H, Uruno T, Shirai T, Takaya D, Matsunaga S, Setoyama D, Watanabe M, Kukimoto-Niino M, Oisaki K, Ushijima M, Sanematsu F, Honma T, Terada T, Oki E, Shirasawa S, Maehara Y, Kang D, Cote J-F, Yokoyama S, Kanai M, Fukui Y
  • Journal Title: Cell Reports Volume: 19 Issue: 5 Pages: 969-980
  • DOI: 10.1016/j.celrep.2017.04.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene. (2017)
  • Author(s): Inoue H, Terachi SI, Uchiumi T, Sato T, Urata M, Ishimura M, Koga Y, Hotta T, Hara T, Kang D, Ohga S.
  • Journal Title: Pediatr Blood Cancer Volume: 2017 Issue: 7 Pages: e26404-e26404
  • DOI: 10.1002/pbc.26404
  • Peer Reviewed
• [Journal Article] Clinical and pathogenic features of SCCmec type II and IV methicillin-resistant Staphylococcus aureus in Japan (2017)
  • Author(s): Mitsumoto-Kaseida Fujiko、Murata Masayuki、Toyoda Kazuhiro、Morokuma Yuiko、Kiyosuke Makiko、Kang Dongchon、Furusyo Norihiro
  • Journal Title: J Infect Chemother. Volume: 23 Issue: 2 Pages: 90-95
  • DOI: 10.1016/j.jiac.2016.11.001
  • Peer Reviewed
• [Journal Article] Mitochondrial nucleic acid binding proteins associated with diseases. (2017)
  • Author(s): Uchiumi T, Kang D
  • Journal Title: Front Biosci Volume: 22 Pages: 168-179
  • Peer Reviewed
• [Presentation] Mitochondrial translational impairment suppresses lysosomal function due to reduced NAD synthesis (2019)
  • Author(s): Uchiumi T, Yagi M, Kang D
  • Organizer: The 16th ASMRM and The 19th J-mit 2019
  • Int'l Joint Research / Invited
• [Presentation] Epigenetic feature of mitochondrial DNA (2019)
  • Author(s): Yasukawa T, Matsuda S, Sakaguchi Y, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D
  • Organizer: The 16th ASMRM and The 19th J-mit 2019
  • Int'l Joint Research
• [Presentation] ミトコンドリア機能低下とリソソーム機能の新規連関 (2019)
  • Author(s): 内海健，康東天
  • Organizer: 第66回日本臨床検査医学会学術集会
• [Presentation] ヒトミトコンドリアDNA転写-複製の新規調節メカニズムの提唱 (2019)
  • Author(s): 松田盛，稲冨鉄平，中田和人，安川武宏，康東天
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] ミトコンドリアDNA複製開始メカニズム解明に向けた転写開始複合体タンパク質へのアプローチ (2019)
  • Author(s): 稲冨鉄平，松田盛，阿部周策，都由羅，石内崇士，中田和人，一柳健司，佐々木裕之，安川武宏，康東天
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 樹状細胞の成熟化におけるミトコンドリアp32の役割 (2019)
  • Author(s): 後藤和人，内海健，康東天
  • Organizer: 第64回日本臨床検査医学会九州地方会／第30回日本臨床化学会九州支部総会合同総会
• [Presentation] 複雑でユニークなミトコンドリアDNA複製メカニズム (2019)
  • Author(s): 安川武宏，松田盛，稲冨鉄平，都由羅，阿部周策，石内崇士，中田和人，一柳健司，佐々木裕之，康東天
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] Mitochondrial Lon protease is a gatekeeper for proteins newly imported into the matrix (2019)
  • Author(s): Matsushima,Y. Takahashi,K. Yue,S. Setoyama,D. Uchiumi,T. Kang,D.
  • Organizer: The 16th ASMRM and The 19th J-mit 2019
• [Presentation] ミトコンドリアマトリクスに局在するプロテアーゼLonによるタンパク質の可溶性制御 (2019)
  • Author(s): 松島雄一，高橋和也，瀬戸山大樹，康東天
  • Organizer: 日本農芸化学会2019年度大会
• [Presentation] ミトコンドリアマトリクスに局在するプロテアーゼLonによるタンパク質の可溶性制御 (2019)
  • Author(s): 松島雄一，高橋和也，岳頌，相原正宗，瀬戸山大樹，康東天
  • Organizer: 第42回日本分子生物学会年会
  • Invited
• [Presentation] Biomarkers for Depression (2018)
  • Author(s): Kang, D
  • Organizer: Shanghai International Forum of Laboratory Medicine
  • Int'l Joint Research / Invited
• [Presentation] Mitochondrial metabolism and immune response in p32-/- cell (2018)
  • Author(s): Kang, D.
  • Organizer: The 19th Congress of PENSA(Parenteral and Enteral Nutrition Society of Asia)
  • Int'l Joint Research / Invited
• [Presentation] Two nationwide reference interval studies conducted in Japan by direct and indirect methods (2018)
  • Author(s): Kang, D
  • Organizer: International Federation of Clinical Chemistry General Conference(IFCC)
  • Int'l Joint Research / Invited
• [Presentation] 日本の臨床検査医の未来 臨床検査の国際化：アジアとの連携 (2018)
  • Author(s): 康 東天
  • Organizer: 第28回臨床検査専門医会 春季大会
  • Invited
• [Presentation] Mitochondria in Innate & adaptive immune responses:roles of p32/C1QBP (2018)
  • Author(s): Kang, D
  • Organizer: Symposium Interactions Dream：Inje University, Busan、
• [Presentation] ミトコンドリアの基礎と疾患 (2018)
  • Author(s): 康 東天
  • Organizer: 小児内分泌勉強会
• [Presentation] Biomarkers for Assessment of the Severity of Depression (2018)
  • Author(s): Dongchon Kang
  • Organizer: The 3rd Shanghai International Forum of Laboratory Medicine
  • Int'l Joint Research / Invited
• [Presentation] Mitochondrial metabolism and immune response in p32 deficient cells (2018)
  • Author(s): Dongchon Kang
  • Organizer: The 19th Congress of Parenteral and Enteral Nutrition Society of Asia
  • Int'l Joint Research / Invited
• [Presentation] 臨床検査専門医のコアアイデンティティー (2017)
  • Author(s): 康 東天
  • Organizer: 第27回臨床検査専門医会
  • Invited
• [Presentation] 共用基準範囲とJLAC検査項目コードの現在と未来 (2017)
  • Author(s): 康 東天
  • Organizer: 第７回静岡県医学検査学会
  • Invited
• [Presentation] Mitochondrial p32 is critical for OXPHOS and TLR-mediated innate immunity (2017)
  • Author(s): Dongchon Kang
  • Organizer: Internatioｎal RFBR workshop 2017
  • Int'l Joint Research / Invited
• [Presentation] ミトコンドリア代謝と病態 (2017)
  • Author(s): 康 東天
  • Organizer: 第57回日本臨床化学会年次学術集会
  • Invited
• [Presentation] 臨床検査ビッグデータの整備と活用 (2017)
  • Author(s): 康 東天
  • Organizer: 第64回日本臨床検査医学会
  • Invited
• [Remarks] 九州大学大学院医学研究院 臨床検査医学
  • URL: http://www.cclm2.med.kyushu-u.ac.jp/