Cardiomyocyte heterogeneity in heart failure

• Project/Area Number: 17H01560
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Komuro Issei 東京大学, 医学部附属病院, 教授 (30260483)
• Co-Investigator(Kenkyū-buntansha): 野村 征太郎 東京大学, 医学部附属病院, 特任助教 (10722118) ; 波多野 将 東京大学, 医学部附属病院, 特任准教授 (20456130) ; 東口 治弘 東京大学, 医学部附属病院, 特任准教授 (40436358)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000); Fiscal Year 2019: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2018: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2017: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
• Keywords: 心不全 / シングルセル解析 / 不均一性 / シングルセル生物学 / 心筋細胞不均一性 / シングルセルRNA-seq解析 / 時空間的遺伝子発現 / シングルセルRNA-seq / イメージング / バイオインフォマティクス / 精密医療 / 心筋細胞 / 遺伝子発現 / イメージング解析 / 分子心臓病学 / 循環器内科学

Outline of Final Research Achievements

Heart failure is caused by dysregulation of mechanical stress response, but the molecular mechanisms underlying cardiomyocyte heterogeneity remain elusive. By integrating single-cell RNA-seq, single-molecule RNA in situ hybridization, genetic perturbation, and molecular pathology, we analyzed molecular heterogeneities in cardiomyocytes from mouse pressure-overload-induced heart failure model and human patients with heart failure. We found that hypertrophied cardiomyocytes, induced by pressure overload, are divided into adaptive and failing cardiomyocytes and that failing cardiomyocytes, which express fetal-type myosin, emerge specifically in the middle layer of the heart. We also demonstrated that DNA damage and p53 signaling are critical for the induction of failing cardiomyocytes and that the content of DNA damage in cardiomyocytes determines the response to medical treatment in patients with heart failure. These findings provide a basis for cardiovascular precision medicine.

Academic Significance and Societal Importance of the Research Achievements

本研究により、心臓細胞のシングルセルレベルの遺伝子発現を空間情報と連結して解析する手法が開発され、心筋細胞のDNA損傷・p53シグナルの病的意義を解明するという学術的に大きな成果が得られた。また、メカニカルストレスの結果として心筋細胞に生じる心筋DNA損傷を定量評価することで、心不全患者の「治療応答性の事前予測」を可能にするという社会的にも待望されてきた心不全層別化手法を確立した。本手法は、臨床現場にて日常的に診断目的で採取する心臓生検組織の検体を有効利用するため患者への追加侵襲が存在しないという大きな利点を有しており、精密医療を心不全臨床において実践する上での基盤的技術となると考えられる。

Research Products

• [Journal Article] Comparison Between Healthcare-Associated and Community-Acquired Infective Endocarditis at Tertiary Care Hospitals in Japan (2020)
  • Author(s): Kiriyama Hiroyuki、Daimon Masao、Nakanishi Koki、Kaneko Hidehiro、Nakao Tomoko、Morimoto-Ichikawa Ryoko、Miyazaki Sakiko、Morita Hiroyuki、Daida Hiroyuki、Komuro Issei
  • Journal Title: Circulation Journal Volume: 84 Issue: 4 Pages: 670-676
  • DOI: 10.1253/circj.CJ-19-0887
  • NAID: 130007815600
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-03-25
  • Peer Reviewed / Open Access
• [Journal Article] Serum uric acid level and subclinical left ventricular dysfunction: a community-based cohort study. (2020)
  • Author(s): Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I.
  • Journal Title: ESC Heart Fail. Volume: - Issue: 3 Pages: 1031-1038
  • DOI: 10.1002/ehf2.12691
  • Peer Reviewed / Open Access
• [Journal Article] Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and?Is?Essential to cGMP-PDE5 Inhibition?Efficacy (2020)
  • Author(s): Fukuma Nobuaki、Takimoto Eiki、Ueda Kazutaka、Liu Pangyen、Tajima Miyu、Otsu Yu、Kariya Taro、Harada Mutsuo、Toko Haruhiro、Koga Kaori、Blanton Robert M.、Karas Richard H.、Komuro Issei
  • Journal Title: JACC: Basic to Translational Science Volume: 5 Issue: 3 Pages: 282-295
  • DOI: 10.1016/j.jacbts.2019.12.009
  • Peer Reviewed / Open Access
• [Journal Article] Association of short-term exposure to air pollution with myocardial infarction with and without obstructive coronary artery disease (2020)
  • Author(s): Ishii Masanobu、Seki Tomotsugu、Kaikita Koichi、Sakamoto Kenji、et al.
  • Journal Title: European Journal of Preventive Cardiology Volume: - Issue: 13 Pages: 1435-1444
  • DOI: 10.1177/2047487320904641
  • Peer Reviewed / Open Access
• [Journal Article] Gender-specific association between the blood pressure category according to the updated ACC/AHA guidelines for hypertension and cardio-ankle vascular index: a community-based cohort study. (2020)
  • Author(s): Kamon T, Kaneko H, Itoh H, Kiriyama H, Mizuno Y, Morita H, Yamamichi N, Komuro I. Gender-specific association between the blood pressure category according to the updated ACC/AHA guidelines for hypertension and cardio-ankle vascular index: a community-based cohort study.
  • Journal Title: J Cardiol. Volume: 75 Issue: 5 Pages: 578-582
  • DOI: 10.1016/j.jjcc.2019.10.007
  • Peer Reviewed
• [Journal Article] Controlling Nutritional Status Score As a Predictive Marker for Patients With Implantable Left Ventricular Assist Device (2020)
  • Author(s): Saito Akihito、Amiya Eisuke、Hatano Masaru、Shiraishi Yasuyuki、Nitta Daisuke、Minatsuki Shun、Maki Hisataka、Hosoya Yumiko、Tsuji Masaki、Bujo Chie、Nawata Kan、Kinoshita Osamu、Kimura Mitsutoshi、Endo Miyoko、Kagami Yukie、Nemoto Mariko、Ikeda Yuichi、Morita Hiroyuki、Ono Minoru、Komuro Issei
  • Journal Title: ASAIO Journal Volume: 66 Issue: 2 Pages: 166-172
  • DOI: 10.1097/mat.0000000000000972
  • Peer Reviewed
• [Journal Article] Nationwide Actions Against Heart Failure Pandemic in Japan ― What Should We Do From Academia? ― (2019)
  • Author(s): Komuro I, Kaneko H, Morita H, Isobe M, Nakayama H, Minematsu K, Yamaguchi T, Yazaki Y.
  • Journal Title: Circulation Journal Volume: 83 Issue: 9 Pages: 1819-1821
  • DOI: 10.1253/circj.CJ-19-0562
  • NAID: 130007695026
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-08-23
  • Peer Reviewed / Open Access
• [Journal Article] Overview of the 83^rd Annual Scientific Meeting of the Japanese Circulation Society ― Renaissance of Cardiology for the Creation of Future Medicine ― (2019)
  • Author(s): Akazawa H, Toko H, Harada M, Ueda K, Kodera S, Kiyosue A, Fujiu K, Hatano M, Daimon M, Ando J, Takimoto E, Morita H, Komuro I
  • Journal Title: Circulation Journal Volume: 83 Issue: 9 Pages: 1829-1835
  • DOI: 10.1253/circj.CJ-19-0587
  • NAID: 130007695023
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-08-23
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Treatment by Female Cardiologists on Short-Term Readmission Rates of Patients Hospitalized With Cardiovascular Diseases (2019)
  • Author(s): Nakayama A, Morita H, Fujiwara T, Komuro I
  • Journal Title: Circulation Journal Volume: 83 Issue: 9 Pages: 1937-1943
  • DOI: 10.1253/circj.CJ-19-0357
  • NAID: 130007695017
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-08-23
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of Left Bundle/Peri-Left Bundle Pacing on Left Ventricular Contraction (2019)
  • Author(s): Hasumi E, Fujiu K, Nakanishi K, Komuro I.
  • Journal Title: Circulation Journal Volume: 83 Issue: 9 Pages: 1965-1967
  • DOI: 10.1253/circj.CJ-19-0399
  • NAID: 130007695022
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-08-23
  • Peer Reviewed / Open Access
• [Journal Article] Cost-Effectiveness of Percutaneous Coronary Intervention Compared With Medical Therapy for Ischemic Heart Disease in Japan (2019)
  • Author(s): Kodera S
  • Journal Title: Circulation Journal Volume: 83 Issue: 7 Pages: 1498-1505
  • DOI: 10.1253/circj.CJ-19-0148
  • NAID: 130007666976
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-06-25
  • Peer Reviewed / Open Access
• [Journal Article] Hospitalization Costs for Patients With Acute Congestive Heart Failure in Japan (2019)
  • Author(s): Kanaoka K, Okayama S, Nakai M, Sumita Y, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y.
  • Journal Title: Circulation Journal Volume: 83 Issue: 5 Pages: 1025-1031
  • DOI: 10.1253/circj.CJ-18-1212
  • NAID: 130007636979
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-04-25
  • Peer Reviewed / Open Access
• [Journal Article] Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy. (2019)
  • Author(s): Ko T, Fujita K, Nomura S, Uemura Y, Yamada S, Tobita T, Katoh M, Satoh M, Ito M, Domoto Y, Hosoya Y, Amiya E, Hatano M, Morita H, Fukayama M, Aburatani H, Komuro I.
  • Journal Title: JACC Basic Transl Sci. Volume: 4 Issue: 6 Pages: 670-680
  • DOI: 10.1016/j.jacbts.2019.05.010
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes (2019)
  • Author(s): Ito Masamichi、Hara Hironori、Takeda Norifumi、Naito Atsuhiko T.、Nomura Seitaro、Kondo Masaki、Hata Yutaka、Uchiyama Masanobu、Morita Hiroyuki、Komuro Issei
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 128 Pages: 90-95
  • DOI: 10.1016/j.yjmcc.2019.01.020
  • Peer Reviewed / Open Access
• [Journal Article] High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload (2019)
  • Author(s): Satoh M、Nomura S、Harada M、Yamaguchi T、Ko T、Sumida T、Toko H、Naito AT.、Takeda N、Tobita T、Fujita T、Ito M、Fujita K、Ishizuka M、Kariya T、Akazawa H、Kobayashi Y、Morita H、Takimoto E、Aburatani H、Komuro I
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 128 Pages: 77-89
  • DOI: 10.1016/j.yjmcc.2018.12.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of visceral adiposity accumulation on adverse left and right ventricular mechanics in the community. (2019)
  • Author(s): Sawada N, Nakanishi K, Daimon M, Yoshida Y, Ishiwata J, Hirokawa M, Nakao T, Morita H, Di Tullio MR, Homma S, Komuro I.
  • Journal Title: Eur J Prev Cardiol. Volume: - Issue: 18 Pages: 2006-2015
  • DOI: 10.1177/2047487319891286
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Alteration of Cardiac Performance and Serum B-Type Natriuretic Peptide Level in Healthy Aging (2019)
  • Author(s): Yoshida Y, Nakanishi K (corresponding), Daimon M, Ishiwata J, Sawada N, Hirokawa M, Kaneko H, Nakao T, Mizuno Y, Morita H, Di Tullio MR, Homma S, Komuro I
  • Journal Title: Journal of the American College of Cardiology Volume: 74 Issue: 14 Pages: 1789-1800
  • DOI: 10.1016/j.jacc.2019.07.080
  • NAID: 40022442752
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan. (2019)
  • Author(s): Kanaoka K, Okayama S, Nakai M, Sumita Y, Onoue K, Soeda T, Nishimura K, Kawakami R, Okura H, Miyamoto Y, Yasuda S, Tsutsui H, Komuro I, Ogawa H, Saito Y.
  • Journal Title: J Am Heart Assoc. Volume: 8 Issue: 18
  • DOI: 10.1161/jaha.119.012282
  • Peer Reviewed / Open Access
• [Journal Article] Significant impact of left ventricular assist device models on the value of flow-mediated dilation: effects of LVAD on endothelial function (2019)
  • Author(s): Watanabe A, Amiya E, Hatano M, Watanabe M, Ozeki A, Nitta D, Maki H, Hosoya Y, Tsuji M, Bujo C, Saito A, Endo M, Kagami Y, Nemoto M, Nawata K, Kinoshita O, Kimura M, Ono M, Komuro I.
  • Journal Title: Heart Vessels Volume: 20 Issue: 2 Pages: 207-213
  • DOI: 10.1007/s00380-019-01474-2
  • Peer Reviewed
• [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M. (2019)
  • Author(s): Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
  • Journal Title: Nature Communications Volume: 10 Issue: 1 Pages: 2824-2833
  • DOI: 10.1038/s41467-019-10859-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical impact of newly developed atrial fibrillation complicated with longstanding ventricular fibrillation during left ventricular assist device support: A case report (2019)
  • Author(s): Bujo Chie、Amiya Eisuke、Hatano Masaru、Tsuji Masaki、Maki Hisataka、Hosoya Yumiko、Fujii Emi、Kamon Tatsuya、Kojima Toshiya、Nawata Kan、Kinoshita Osamu、Kimura Mitsutoshi、Ono Minoru、Komuro Issei
  • Journal Title: BMC Cardiovascular Disorders Volume: 19 Issue: 1 Pages: 1604-1604
  • DOI: 10.1186/s12872-019-1132-1
  • Peer Reviewed / Open Access
• [Journal Article] Left Main Coronary Artery Obstruction by Huge Noncoronary Cusp Calcification After Transcatheter Aortic Valve Replacement. (2019)
  • Author(s): Kiriyama H, Kaneko H, Itoh H, Uehara M, Kodera S, Kiyosue A, Yamauchi H, Daimon M, Ando J, Morita H, Ono M, Komuro I.
  • Journal Title: JACC Cardiovasc Interv. Volume: 12 Issue: 13 Pages: 1285-1287
  • DOI: 10.1016/j.jcin.2019.01.243
  • Peer Reviewed
• [Journal Article] Relation between the Updated Blood Pressure Classification according to the American College of Cardiology/American Heart Association Guidelines and Carotid Intima-Media Thickness. (2019)
  • Author(s): Itoh H, Kaneko H, Kiriyama H, Yoshida Y, Nakanishi K, Mizuno Y, Daimon M, Morita H, Yatomi Y, Komuro I.
  • Journal Title: Am J Cardiol. Volume: 124 Issue: 3 Pages: 396-401
  • DOI: 10.1016/j.amjcard.2019.04.054
  • Peer Reviewed
• [Journal Article] The potential of cardiac rehabilitation as a method of suppressing abdominal aortic aneurysm expansion: a pilot study. (2019)
  • Author(s): Nakayama A1, Amiya E2, Morita H2, Hyodo K2, Takayama N2, Konishi Y2, Taya M2, Fujiwara T, Hosoya Y2, Hoshina K3, Komuro I2.
  • Journal Title: Heart Vessels. Volume: 34 Issue: 12 Pages: 2031-2039
  • DOI: 10.1007/s00380-019-01441-x
  • Peer Reviewed
• [Journal Article] Endothelial Cell?Derived Angiocrines Elicit Physiological Cardiomyocyte Hypertrophy (2019)
  • Author(s): Ueda Kazutaka、Toko Haruhiro、Komuro Issei
  • Journal Title: Circulation Volume: 139 Issue: 22 Pages: 2585-2587
  • DOI: 10.1161/circulationaha.119.040632
  • Peer Reviewed
• [Journal Article] Genetic basis of hereditary thoracic aortic aneurysms and dissections (2019)
  • Author(s): Takeda Norifumi、Komuro Issei
  • Journal Title: Journal of Cardiology Volume: 74 Issue: 2 Pages: 136-143
  • DOI: 10.1016/j.jjcc.2019.03.014
  • Peer Reviewed
• [Journal Article] Progressive Right Ventricular Aneurysm in a Patient with Systemic Sarcoidosis (2019)
  • Author(s): Hirose Kazutoshi、Amiya Eisuke、Ishizuka Masato、Uehara Masae、Komuro Issei
  • Journal Title: Journal of Cardiovascular Imaging Volume: 27 Issue: 2 Pages: 158-158
  • DOI: 10.4250/jcvi.2019.27.e18
  • Peer Reviewed / Open Access
• [Journal Article] Abdominal skeletal muscle mass as a predictor of mortality in Japanese patients undergoing left ventricular assist device implantation (2019)
  • Author(s): Tsuji Masaki、Amiya Eisuke、Hatano Masaru、Nitta Daisuke、Maki Hisataka、Bujo Chie、Saito Akihito、Hosoya Yumiko、Minatsuki Shun、Hara Toru、Nemoto Mariko、Kagami Yukie、Endo Miyoko、Kimura Mitsutoshi、Kinoshita Osamu、Nawata Kan、Morita Hiroyuki、Ono Minoru、Komuro Issei
  • Journal Title: ESC Heart Failure Volume: 6 Issue: 3 Pages: 526-535
  • DOI: 10.1002/ehf2.12429
  • Peer Reviewed / Open Access
• [Journal Article] The Significance of the Effect of Visceral Adiposity on Left Ventricular Diastolic Function in the General Population (2019)
  • Author(s): Sawada Naoko、Daimon Masao、Kawata Takayuki、Nakao Tomoko、Kimura Koichi、Nakanishi Koki、Kurano Makoto、Hirokawa Megumi、Xu Boqing、Yamanaka Yuko、Kato Tomoko S.、Watanabe Masafumi、Yatomi Yutaka、Komuro Issei
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 4435-4435
  • DOI: 10.1038/s41598-018-37137-x
  • Peer Reviewed / Open Access
• [Journal Article] Emergency percutaneous coronary intervention for left main trunk thrombus following orthotopic heart transplantation. (2019)
  • Author(s): Tsuji M, Nitta D, Minatsuki S, Maki H, Hosoya Y, Amiya E, Hatano M, Takimoto E, Kinoshita O, Nawata K, Ono M, Komuro I.
  • Journal Title: ESC Heart Fail. Volume: 6 Issue: 3 Pages: 575-578
  • DOI: 10.1002/ehf2.12422
  • Peer Reviewed
• [Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation. (2019)
  • Author(s): Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, et al.
  • Journal Title: Circulation Volume: In press Issue: 18 Pages: 2157-2169
  • DOI: 10.1161/circulationaha.118.036761
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure. (2018)
  • Author(s): Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I.
  • Journal Title: Nat Commun. Volume: 9 Issue: 1 Pages: 4435-4435
  • DOI: 10.1038/s41467-018-06639-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genetic basis of cardiomyopathy and the genotypes involved in prognosis and left ventricular reverse remodeling (2018)
  • Author(s): Tobita T, Nomura S, Fujita T, Morita H, Asano Y, Onoue K, Ito M, Imai Y, Suzuki A, Ko T, Satoh M, Fujita K, Naito AT, Furutani Y, Toko H, Harada M, Amiya E, Hatano M, Takimoto E, Shiga T, Nakanishi T, Sakata Y, Ono M, Saito Y, Takashima S, Hagiwara N, Aburatani H, Komuro I.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 20114-20119
  • DOI: 10.1038/s41598-018-20114-9
  • Peer Reviewed / Open Access
• [Journal Article] Biased Agonism at the Angiotensin Receptor: Blocker and Calcium Sensitizer at the Same Time. (2017)
  • Author(s): Woo AY, Komuro I, Xiao RP.
  • Journal Title: Circulation Volume: 135 Issue: 11 Pages: 1071-1074
  • DOI: 10.1161/circulationaha.117.027276
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. (2017)
  • Author(s): Kamo T, Akazawa H, Suda W, Saga-Kamo A, Shimizu Y, Yagi H, Liu Q, Nomura S, Naito AT, Takeda N, Harada M, Toko H, Kumagai H, Ikeda Y, Takimoto E, Suzuki JI, Honda K, Morita H, Hattori M, Komuro I.
  • Journal Title: PLoS One. Volume: 12 Issue: 3 Pages: 0174099-0174099
  • DOI: 10.1371/journal.pone.0174099
  • Peer Reviewed / Open Access
• [Journal Article] A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation and cellular communication (2017)
  • Author(s): Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I
  • Journal Title: Nature Medicine Volume: 印刷中 Issue: 5 Pages: 611-622
  • DOI: 10.1038/nm.4326
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] DNA single-strand break-induced DNA damage response causes heart failure. (2017)
  • Author(s): Higo T, Naito AT, Sumida T, Shibamoto M, Okada K, Nomura S, Nakagawa A, Yamaguchi T, Sakai T, Hashimoto A, Kuramoto Y, Ito M, Hikoso S, Akazawa H, Lee JK, Shiojima I, McKinnon PJ, Sakata Y, Komuro I.
  • Journal Title: Nature Communications Volume: 8 Issue: 1 Pages: 15104-15104
  • DOI: 10.1038/ncomms15104
  • Peer Reviewed / Open Access
• [Journal Article] Identification of MYLK3 mutations in familial dilated cardiomyopathy (2017)
  • Author(s): Tobita Takashige、Nomura Seitaro、Morita Hiroyuki、Ko Toshiyuki、Fujita Takanori、Toko Haruhiro、Uto Kenta、Hagiwara Nobuhisa、Aburatani Hiroyuki、Komuro Issei
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 17495-17495
  • DOI: 10.1038/s41598-017-17769-1
  • Peer Reviewed / Open Access
• [Presentation] Epigenetic Regulation of Cardiovascular Disease (2019)
  • Author(s): Issei Komuro
  • Organizer: Gordon Research Conference
  • Int'l Joint Research / Invited
• [Presentation] Molecular Mechanisms of Heart Failure Dissected by Single Cell RNA Saquence Analysis (2019)
  • Author(s): Issei Komuro
  • Organizer: 2019 XXIII ISHR WORLD CONGRESS
  • Int'l Joint Research / Invited
• [Presentation] Inflammageing (2019)
  • Author(s): Issei Komuro
  • Organizer: European Society of Cardiology
  • Int'l Joint Research / Invited
• [Presentation] 心不全パンデミック時代における研究の重要性 (2019)
  • Author(s): 小室一成
  • Organizer: 第29回日本心臓核医学会総会学術大会
  • Invited
• [Presentation] 日本腫瘍循環器学会の活動―個から組織へ (2019)
  • Author(s): 小室一成
  • Organizer: 第2回日本腫瘍循環器学会学術集会
  • Invited
• [Presentation] 基礎研究はどこまで循環器病の謎を解いたか -新しい循環器病学の時代へ (2019)
  • Author(s): 小室一成
  • Organizer: 第23回日本心不全学会
  • Invited
• [Presentation] 循環器学会の基本法への期待と学会会員諸氏への要望 (2019)
  • Author(s): 小室一成
  • Organizer: 第253回日本循環器学会関東甲信越地方会
  • Invited
• [Presentation] Task and Future Outlook of Cardiology - History of 30 Years as a Physician Scientist (2019)
  • Author(s): 小室 一成
  • Organizer: 第83回日本循環器学会学術集会
  • Invited
• [Presentation] Emerging Role of Cell Regeneration in Cardiac Dysfunction (2018)
  • Author(s): Issei Komuro
  • Organizer: Asian Pacific Society of Cardiology Congress 2018
  • Int'l Joint Research / Invited
• [Presentation] 会長講演・心不全研究の過去、現在、未来 (2018)
  • Author(s): 小室 一成
  • Organizer: 第22回日本心不全学会学術集会
  • Invited
• [Presentation] Comprehensive targeted sequencing of cardiomyopathy and its relation to phenotype (2018)
  • Author(s): Seitaro Nomura
  • Organizer: European Society of Cardiology 2018
  • Int'l Joint Research / Invited
• [Presentation] Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure (2018)
  • Author(s): Seitaro Nomura
  • Organizer: Scientific Sessions of the American Heart Association 2018
  • Int'l Joint Research
• [Presentation] 教育講演 心不全の予防と新しい治療 (2017)
  • Author(s): 小室一成
  • Organizer: 第114回日本内科学会総会・講演会
  • Invited
• [Presentation] Hypertension Summit: 未来を創る高血圧学－高血圧関連学会知事長からの提言 (2017)
  • Author(s): 小室一成
  • Organizer: 第40回日本高血圧学会総会
  • Invited
• [Presentation] Regernation of the Heart (2017)
  • Author(s): Issei Komuro
  • Organizer: 47th Annual Convention and Scientific Session of the Taiwan Society of Cardiology
  • Invited
• [Presentation] Personal Insights and Perspectives (2017)
  • Author(s): Issei Komuro
  • Organizer: 47th Annual Convention and Scientific Session of the Taiwan Society of Cardiology
  • Invited
• [Presentation] Novel Mechanisms of heart Failure (2017)
  • Author(s): Issei Komuro
  • Organizer: The 11th Oriental Cardiology Conference
  • Invited
• [Presentation] Molecular Cardiology in Clinical Practice (2017)
  • Author(s): Issei Komuro
  • Organizer: Asian Pacific Society of Cardiology Congress 2017
  • Invited
• [Presentation] The Role of Macrophage in the Heart (2017)
  • Author(s): Issei Komuro
  • Organizer: Korean Society of Cardiometabolic Syndrome 2017 Scientific Session
  • Invited
• [Book] Cutting Edge of Molecular Cardiology 新しい臨床を開拓するための分子循環器病学 (2019)
  • Author(s): 小室一成
  • Total Pages: 210
  • Publisher: 南山堂
  • ISBN: 9784525249410
• [Book] 別冊医学のあゆみ 遺伝性心血管疾患のすべて (2019)
  • Author(s): 小室一成
  • Total Pages: 136
  • Publisher: 医歯薬出版
• [Book] 医学のあゆみ 遺伝性心血管疾患のすべて 2019年 268巻9号 (2019)
  • Author(s): 小室 一成
  • Total Pages: 120
  • Publisher: 医歯薬出版
• [Book] 医学のあゆみ 心不全のすべて 分子生物学から緩和ケアまで:beyondガイドライン 2018年 266巻13号 (2018)
  • Author(s): 小室 一成
  • Total Pages: 302
  • Publisher: 医歯薬出版
• [Patent(Industrial Property Rights)] 心不全患者の心機能回復可能性の評価方法 (2019)
  • Inventor(s): 野村征太郎、候聡志、油谷浩幸、小室一成
  • Industrial Property Rights Holder: 野村征太郎、候聡志、油谷浩幸、小室一成
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] 虚血性心疾患発症と予後を予測するゲノムリスクスコア (2019)
  • Inventor(s): 伊藤薫、野村征太郎、赤澤宏、小室一成
  • Industrial Property Rights Holder: 伊藤薫、野村征太郎、赤澤宏、小室一成
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
• [Patent(Industrial Property Rights)] DNA損傷応答を指標にした心不全層別化バイオマーカーの開発 (2018)
  • Inventor(s): 野村征太郎・小室一成・候聡志・油谷浩幸
  • Industrial Property Rights Holder: 野村征太郎・小室一成・候聡志・油谷浩幸
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018
  • Overseas