| Budget Amount *help |
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2020: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2019: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2018: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2017: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
Neuronal relay systems play critical roles in communicating metabolic information among organs/tissues and maintaining glucose homeostasis at the whole-body level. We have further advanced our previous achievements. This study showed the molecular mechanisms of neuron-derived pancreatic β cell proliferation. First, combination of acetylcholine and PACAP induced β cell proliferation. In addition, we showed the FoxM1 pathway in β cells to enhance cell cycle, leading to beta cell proliferation. Furthermore, stimulation of abdominal vagal nerve per se was shown to promote both insulin secretion acutely and β cell proliferation chronically.
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