Analysis of developmental programs that diabetes mellitus disturbs and the mechanism
| Project/Area Number |
17H01571
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
Meno Chikara 九州大学, 医学研究院, 教授 (20311764)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2020: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Keywords | 左右軸 / 糖尿病 / 先天異常 / 初期発生 / 胚発生 / 発生・分化 |
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| Outline of Final Research Achievements |
When females with diabetes become pregnant, the risk of their infant developing various congenital anomalies, including heterotaxy syndrome, increases. In this project, we analyzed the abnormal left-right axis in embryos derived from diabetic female mice. We found that the type of abnormal left-right axis changes depending on the feed components and feeding methods of diabetic female mice. Additionally, to understand the relationship between diabetic embryopathy and Wnt signaling, we created a new Wnt reporter mouse and analyzed a new mutant mouse lacking Wnt3a enhancer that we identified.
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| Academic Significance and Societal Importance of the Research Achievements |
世界的な糖尿病患者の増加から、糖尿病に罹患した女性の子に発生する様々な先天異常について理解し、予防することの重要性が高まっている。本研究では、普段摂取する食事が内臓錯位症候群のタイプに影響することがマウスの実験によって示唆された。また、胚発生に必須の役割を果たすWntを解析するための、新しいマウスを作出した。
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Report
(5 results)
Research Products
(14 results)
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[Journal Article] Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation.2020
Author(s)
Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, Chikara Meno, Eri Nakamura, Norihiro Tada, Yoshinori Fukui, Junichi Kikuta, Masaru Ishii, Yukihiko Sugimoto, and Mitsuyoshi Nakao, Takehiko Yokomizo.
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Journal Title
Cellular & Molecular Immunology
Volume: 8
Issue: 6
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters.2018
Author(s)
Nabeshima R, Nishimura O, Maeda T, Shimizu N, Ide T, Yashiro K, Sakai Y, Meno C, Kadota M, Shiratori H, Kuraku S, Hamada H
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access
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