| Budget Amount *help |
¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
Fiscal Year 2020: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2017: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Outline of Final Research Achievements |
When females with diabetes become pregnant, the risk of their infant developing various congenital anomalies, including heterotaxy syndrome, increases. In this project, we analyzed the abnormal left-right axis in embryos derived from diabetic female mice. We found that the type of abnormal left-right axis changes depending on the feed components and feeding methods of diabetic female mice. Additionally, to understand the relationship between diabetic embryopathy and Wnt signaling, we created a new Wnt reporter mouse and analyzed a new mutant mouse lacking Wnt3a enhancer that we identified.
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