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Cancer vaccine therapy using peptide pulsed iPS derived DCs for pancreas cancer patients

Research Project

Project/Area Number 17H01580
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionWakayama Medical University

Principal Investigator

山上 裕機  和歌山県立医科大学, 医学部, 教授 (20191190)

Co-Investigator(Kenkyū-buntansha) 北畑 裕司  和歌山県立医科大学, 医学部, 学内助教 (00535338)
川井 学  和歌山県立医科大学, 医学部, 准教授 (40398459)
岡田 健一  和歌山県立医科大学, 医学部, 講師 (50407988)
勝田 将裕  和歌山県立医科大学, 医学部, 准教授 (50464673)
尾島 敏康  和歌山県立医科大学, 医学部, 講師 (60448785)
廣野 誠子  和歌山県立医科大学, 医学部, 講師 (60468288)
宮澤 基樹  和歌山県立医科大学, 医学部, 講師 (90549734)
清水 敦史  和歌山県立医科大学, 医学部, 博士研究員 (00637910)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Granted (Fiscal Year 2020)
Budget Amount *help
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2020: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2019: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2018: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2017: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
KeywordsiPS細胞 / 樹状細胞 / がんワクチン / 膵癌 / カクテルペプチド / 癌ワクチン / ペプチド / 臨床試験 / 膵癌ワクチン / 膵癌免疫療法
Outline of Annual Research Achievements

令和元年度は昨年度に引き続きエピソーマル・プラスミド法で誘導したiPS-DCの抗腫瘍効果の解析を行った.KIF20A, MUC16, Mesothe lin, VEGFR1, R2発現プラスミドベクターを作成し,各蛋白の発現をFACSおよびウエスタンブロッティングで確認した.このベクターを健常人由来iPS-DCにエレクトロポレーション法で導入し,2日間培養した.刺激後のDCの表面マーカーCD80, CD83 , CD86, MHC-classI,classIIおよびCCR7, TLR2,4を確認したところ,刺激前と比較し,CD80 (75%が88%), CD86 (86%が98%), CCR7 (45%が62%)の発現増強をFACSにて確認した.続いて,刺激後iPS-DCをstimulatorとし,PBMCとin vitro刺激を3回行い,bulk CTLを誘導し,その後MACSにてCD8 CTLを誘導した.現在,メソテリン遺伝子導入LCLを疑似ターゲットとした細胞傷害活性をCrリリース法にて確認している.
また令和元年度は前臨床試験(iPS-DCの品質管理) を開始した.具体的には,細胞表面マーカーの解析;3x105個のカクテルペプチド刺激iPS-DCをflow cytometryを用いてisotype (1k, 2ak)およびCD86,HLA-DRを解析した。無菌試験;日本薬局方無菌試験法に従い、メンブレンフィルター法で液体チオグリコール酸培地・ソイビ ーン・カゼインダイジェスト培地を使用して、14日間培養して無菌性を担保した.現在,エンドトキシン測定およびマイコプラズマ否定試験を行っている.

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

KIF20A, MUC16, Mesothe lin, VEGFR1, R2発現プラスミドベクターの作製に難渋した.各遺伝子の連結がうまくいかず,VEGFR1 R2遺伝子の導入が困難であった.試行錯誤のうえ,コザック配列をVEGFR1 R2遺伝子の上流に挿入することで、スムーズな蛋白発現が可能となった.その後のin vitro CTLの誘導は問題なく行えている.また令和元年度はiPS-DCの前臨床試験を開始した.本研究の臨床応用実現に向け,着実に研究は進んでいる.以上よりおおむね順調に進展しているとした.

Strategy for Future Research Activity

令和2年度は引き続き,カクテルペプチド刺激iPS-DCのメソテリン特異的な細胞傷害活性の測定を行う.健常人ドナー5名のiPS-DCがすでに誘導されており,またおのおののLCLの樹立も終了している.まずは,ドナーLCLにメソテリン遺伝子を導入した疑似の陽性ターゲット,またコントロールベクターにて作成したネガティブターゲットを利用し,in vitro CTLが,メソテリン特異的な細胞傷害活性を有することを確認する.その後,VEGFR1 R2遺伝子導入に伴う,腫瘍新生血管をターゲットとしたCTL assayを行う.必要に応じ,CTLクローンを誘導する予定である.LCLをターゲットとした研究が終了したら,腫瘍細胞株を用いた研究を行う.HLA A24陽性のドナー3名よりin vitro CTLを誘導し,同様にHLA A24陽性かつメソテリンを発現しているMIAPACA2, Pan01をターゲットとした細胞傷害活性誘導を試みる.
iPS-DCの前臨床試験に関しては,無菌試験;日本薬局方無菌試験法に従い、メンブレンフィルター法で液体チオグリコール酸培地・ソイビ ーン・カゼインダイジェスト培地を使用して、14日間培養して無菌性を担保する.エンドトキシン測定;日本薬局方エンドトキシン試験に従 い、検量線の信頼性確認試験を行う.エンドトキシンによる試薬の活性化に伴って形成されるゲルによる吸光度を測定する. マイコプラズマ否定試験;日本薬局方マイコプラズマ否定試験に従ってPCRで解析する.一般毒性試験(間歇投与試験);用量段階は1用量 とし、げっ歯類1種のヌードマウスを20例で検討する。iPS-DC投与数は1x106個/kgで、皮内に3回間歇的に投与する.

Report

(3 results)
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report

Research Products

(64 results)

All 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade.2020

    • Author(s)
      Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T.
    • Journal Title

      Br J Cancer.

      Volume: 122 Pages: 1185-1193

    • DOI

      10.1038/s41416-020-0757-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma.2019

    • Author(s)
      Kim Sangchul、Bolatkan Amina、Kaneko Syuzo、Ikawa Noriko、Asada Ken、Komatsu Masaaki、Hayami Shinya、Ojima Hidenori、Abe Nobutsugu、Yamaue Hiroki、Hamamoto Ryuji
    • Journal Title

      Biomolecules.

      Volume: 9 Pages: 810-810

    • DOI

      10.3390/biom9120810

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA.2019

    • Author(s)
      Mizuno Kei、Akamatsu Shusuke、Sumiyoshi Takayuki、Wong Jing Hao、Fujita Masashi et al.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 15017-15017

    • DOI

      10.1038/s41598-019-51459-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of CEACAM1 is associated with poor prognosis and peritoneal dissemination of patients with gastric cancer2019

    • Author(s)
      Takeuchi A, Yokoyama S, Nakamori M, Nakamura M, Ojima T, Yamaguchi S, Mitani Y, Shively JE, Yamaue H.
    • Journal Title

      Scientific Report

      Volume: 9 Pages: 12702-12702

    • DOI

      10.1038/s41598-019-49230-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic analysis of pancreatic juice DNA assesses malignant risk of intraductal papillary mucinous neoplasm of pancreas.2019

    • Author(s)
      Mateos Raul N.、Nakagawa Hidewaki、Hirono Seiko、...、Fujita Masashi
    • Journal Title

      Cancer Med

      Volume: 8 Pages: 4565-4573

    • DOI

      10.1002/cam4.2340

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robotic radical lymphadenectomy without touching the pancreas during gastrectomy for gastric cancer.2019

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Maruoka S, Yamaue H.
    • Journal Title

      Medicine

      Volume: 98

    • DOI

      10.1097/md.0000000000015091

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decreased serum carbohydrate antigen 19-9 levels after neoadjuvant therapy predict a better prognosis for patients with pancreatic adenocarcinoma: a multicenter case-control study of 240 patients.2019

    • Author(s)
      Aoki S, Motoi F, Murakami Y, Sho M, Satoi S, Honda G, Uemura K, Okada KI, Matsumoto I, Nagai M, Yanagimoto H, Kurata M, Fukumoto T, Mizuma M, Yamaue H, Unno M; Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS).
    • Journal Title

      BMC Cancer

      Volume: 19 Pages: 252-252

    • DOI

      10.1186/s12885-019-5460-4

    • NAID

      120006604677

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Triplet chemotherapy with docetaxel, cisplatin and S-1 for unresectable advanced squamous cell carcinoma of the esophagus: phase I/II trial results.2019

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Oncotarget.

      Volume: 10 Pages: 847-855

    • DOI

      10.18632/oncotarget.26614

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Triangulating stapling vs functional end-to-end stapling for cervical esophagogastric anastomosis after esophagectomy for thoracic esophageal cancer: study protocol for a randomized controlled trial.2019

    • Author(s)
      Tsuji T, Ojima T, Nakamori M, Nakamura M, Katsuda M, Hayata K, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Trials.

      Volume: 20 Pages: 83-83

    • DOI

      10.1186/s13063-019-3201-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concomitant Use of Indocyanine Green Fluorescence Imaging and Interventional Radiology for Detection of Liver Segments During Laparoscopic Anatomical Liver Resection: Pilot Feasibility Study.2019

    • Author(s)
      Ueno M, Hayami S, Sonomura T, Kawai M, Hirono S, Okada KI, Tanaka R, Yamaue H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: in press

    • DOI

      10.1097/sle.0000000000000631

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Impact of Neoadjuvant Chemotherapy and Chemoradiotherapy in Borderline Resectable Pancreatic Cancer: Analysis of 884 Patients at Facilities Specializing in Pancreatic Surgery.2019

    • Author(s)
      Nagakawa Y, Sahara Y, Hosokawa Y, Murakami Y, Yamaue H, Satoi S, Unno M, Isaji S, Endo I, Sho M, Fujii T, Takishita C, Hijikata Y, Suzuki S, Kawachi S, Katsumata K, Ohta T, Nagakawa T, Tsuchida A.
    • Journal Title

      Ann Surg Oncol.

      Volume: in press

    • DOI

      10.1245/s10434-018-07131-8

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomized phase II/III trial of neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer (Prep-02/JSAP05).2019

    • Author(s)
      Motoi F, Kosuge T, Ueno H, Yamaue H, Satoi S, Sho M, Honda G, Matsumoto I, Wada K, Furuse J, Matsuyama Y, Unno M; Study Group of Preoperative Therapy for Pancreatic Cancer (Prep) and Japanese Study Group of Adjuvant Therapy for Pancreatic cancer (JSAP).
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 49 Pages: 190-194

    • DOI

      10.1093/jjco/hyy190

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robotic complete lymphadenectomy at the splenic hilum during total gastrectomy for advanced gastric cancer (with video).2019

    • Author(s)
      Ojima T, Hayata K, Yamaue H.
    • Journal Title

      J Visc Surg.

      Volume: in press

    • DOI

      10.1016/j.jviscsurg.2018.12.005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitoryfunctions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murinetumor microenvironment2019

    • Author(s)
      Umezu D, Okada N, Sakoda Y, Adachi K, Ojima T, Yamaue H, Eto M, Tamada K.
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 68 Pages: 201-211

    • DOI

      10.1007/s00262-018-2263-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sustained Elevation of Postoperative Serum Level of Carbohydrate Antigen 19-9 is High-Risk Stigmata for Primary Hepatic Recurrence in Patients with Curatively Resected Pancreatic Adenocarcinoma2019

    • Author(s)
      Motoi F, Murakami Y, Okada KI, Matsumoto I, Uemura K, Satoi S, Sho M, Honda G, Fukumoto T, Yanagimoto H, Kinoshita S, Kurata M, Aoki S, Mizuma M, Yamaue H, Unno M; Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS).
    • Journal Title

      World Journal of Surgery

      Volume: 43 Pages: 634-641

    • DOI

      10.1007/s00268-018-4814-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conversion Surgery for Gastric Cancer with Peritoneal Metastasis Based on the Diagnosis of Second-Look Staging Laparoscopy2019

    • Author(s)
      Nakamura M, Ojima T, Nakamori M, Katsuda M, Tsuji T, Hayata K, Kato T, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: in prss Pages: 1758-1766

    • DOI

      10.1007/s11605-018-3983-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal timing of removal of epidural and urethal catheters to avoid postoperative urinary retention undergoing abdominal surgery2019

    • Author(s)
      Hayami S, Ueno M, Kawai M, Kuriyama T, Kawamata T, Yamaue H.
    • Journal Title

      Dig Sure

      Volume: 36 Pages: 261-265

    • DOI

      10.1159/000490199

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modified Blumgart Mattress Suture Versus Conventional Interrupted Suture in Pancreaticojejunostomy During Pancreaticoduodenectomy: Randomized Controlled Trial.2019

    • Author(s)
      Hirono S, Kawai M, Okada KI, Miyazawa M, Kitahata Y, Hayami S, Ueno M, Yamaue H.
    • Journal Title

      Ann Surg.

      Volume: 269 Pages: 243-251

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MAPLE-PD trial (Mesenteric Approach vs. Conventional Approach for Pancreatic Cancer during Pancreaticoduodenectomy): study protocol for a multicenter randomized controlled trial of 354 patients with pancreatic ductal adenocarcinoma.2018

    • Author(s)
      Hirono S, Kawai M, Okada KI, Fujii T, Sho M, Satoi S, Amano R, Eguchi H, Mataki Y, Nakamura M, Matsumoto I, Baba H, Tani M, Kawabata Y, Nagakawa Y, Yamada S, Murakami Y, Shimokawa T, Yamaue H.
    • Journal Title

      Trials.

      Volume: 19 Pages: 613-613

    • DOI

      10.1186/s13063-018-3002-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma2018

    • Author(s)
      Shigekawa Y, Hayami S, Ueno M, Miyamoto A, Suzaki N, Kawai M, Hirono S, Okada KI, Hamamoto R, Yamaue H.
    • Journal Title

      Oncotarget

      Volume: 9 Pages: 34320-334335

    • DOI

      10.18632/oncotarget.26144

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transition of serum cytokines following pancreaticoduodenectomy: A subsidiary study of JAPAN-PD.2018

    • Author(s)
      Maeda H, Okada KI, Fujii T, Oba MS, Kawai M, Hirono S, Kodera Y, Sho M, Akahori T, Shimizu Y, Ambo Y, Kondo N, Murakami Y, Ohuchida J, Eguchi H, Nagano H, Sakamoto J, Yamaue H.
    • Journal Title

      Oncol Lett.

      Volume: 16 Pages: 6847-6853

    • DOI

      10.3892/ol.2018.9422

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcomes of 1,639 hepatectomies for non-colorectal non-neuroendocrine liver metastases: a multicenter analysis2018

    • Author(s)
      Sano K, Yamamoto M, Mimura T, Endo I, Nakamori S, Konishi M, Miyazaki M, Wakai T, Nagino M, Kubota K, Unno M, Sata N, Yamamoto J, Yamaue H, Takada T; Japanese Society of Hepato-Biliary-Pancreatic Surgery.
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 25 Pages: 465-475

    • DOI

      10.1002/jhbp.587

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Learning curve and surgical factors influencing the surgical outcomes during the initial experience with laparoscopic pancreaticoduodenectomy.2018

    • Author(s)
      Nagakawa Y, Nakamura Y, Honda G, Gotoh Y, Ohtsuka T, Ban D, Nakata K, Sahara Y, Velasquez VVDM, Takaori K, Misawa T, Kuroki T, Kawai M, Morikawa T, Yamaue H, Tanabe M, Mou Y, Lee WJ, Shrikhande SV, Conrad C, Han HS, Tang CN, Palanivelu C, Kooby DA, Asbun HJ, Wakabayashi G, Tsuchida A, Takada T, Yamamoto M, Nakamura M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 498-507

    • DOI

      10.1002/jhbp.586

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intensive perioperative rehabilitation improves surgical outcomes after pancreaticoduodenectomy.2018

    • Author(s)
      Kitahata Y, Hirono S, Kawai M, Okada KI, Miyazawa M, Shimizu A, Kobayashi R, Ueno M, Hayami S, Shimokawa T, Kouda K, Tajima F, Yamaue H.
    • Journal Title

      Langenbecks Arch Surg.

      Volume: 403 Pages: 711-718

    • DOI

      10.1007/s00423-018-1710-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Endoscopic treatment of esophageal fistulas after esophagectomy with injection of an alpha-cyanoacrylate monomer: a phase II study.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Tsuji T, Maruoka S, Yamaue H.
    • Journal Title

      Endosc Int Open.

      Volume: 6

    • DOI

      10.1055/a-0581-9005

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neoadjuvant Chemotherapy with Docetaxel, Cisplatin and S-1 for Resectable Advanced Esophageal Cancer.2018

    • Author(s)
      Hayata K, Ojima T, Nakamori M, Nakamura M, Katsuda M, Kitadani J, Takeuchi A, Tabata H, Maruoka S, Yamaue H.
    • Journal Title

      Anticancer Res.

      Volume: 38 Pages: 5267-5273

    • DOI

      10.21873/anticanres.12852

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reinforced Stapling Technique for Reconstruction After Laparoscopic Distal Gastrectomy.2018

    • Author(s)
      Ojima T, Nakamura M, Hayata K, Nakamori M, Yamaue H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: 28 Pages: 334-336

    • DOI

      10.1097/sle.0000000000000570

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correction: Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.2018

    • Author(s)
      Furuta M, Tanaka H, Shiraishi Y, Uchida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H.
    • Journal Title

      Oncotarget.

      Volume: 9 Pages: 31789-31789

    • DOI

      10.18632/oncotarget.25960

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a novel HLA-A24-restricted cytotoxic T lymphocyte epitope peptide derived from mesothelin in pancreatic cancer.2018

    • Author(s)
      Tsukagoshi M, Wada S, Hirono S, Yoshida S, Yada E, Sasada T, Shirabe K, Kuwano H, Yamaue H.
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 59 Pages: 31448-31458

    • DOI

      10.18632/oncotarget.25837

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Difficulty scoring system in laparoscopic distal pancreatectomy.2018

    • Author(s)
      Ohtsuka T, Ban D, Nakamura Y, Nagakawa Y, Tanabe M, Gotoh Y, Velasquez VVDM, Nakata K, Sahara Y, Takaori K, Honda G, Misawa T, Kawai M, Yamaue H, Morikawa T, Kuroki T, Mou Y, Lee WJ, Shrikhande SV, Tang CN, Conrad C, Han HS, Palanivelu C, Asbun HJ, Kooby DA, Wakabayashi G, Takada T, Yamamoto M, Nakamura M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 489-497

    • DOI

      10.1002/jhbp.578

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distal Pancreatectomy with Celiac Axis Resection (DP-CAR) for Pancreatic Cancer. How I do It.2018

    • Author(s)
      Klompmaker S, Boggi U, Hackert T, Salvia R, Weiss M, Yamaue H, Zeh HJ, Besselink MG.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 1804-1810

    • DOI

      10.1007/s11605-018-3894-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Significance of hepatic resection and adjuvant hepatic arterial infusion chemotherapy for hepatocellular carcinoma with portal vein tumor thrombus in the first branch of portal vein and the main portal trunk: a project study for hepatic surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery.2018

    • Author(s)
      Hatano E, Uemoto S, Yamaue H, Yamamoto M; Japanese Society of Hepato-Biliary-Pancreatic Surgery.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 395-402

    • DOI

      10.1002/jhbp.574

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resection for recurrent pancreatic cancer in the remnant pancreas after pancreatectomy is clinically promising: Results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.2018

    • Author(s)
      Yamada S, Kobayashi A, Nakamori S, Baba H, Yamamoto M, Yamaue H, Fujii T.
    • Journal Title

      Surgery.

      Volume: 164 Pages: 1049-1056

    • DOI

      10.1016/j.surg.2018.05.050

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robotic versus laparoscopic gastrectomy with lymph node dissection for gastric cancer: study protocol for a randomized controlled trial.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Kitadani J, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Trials.

      Volume: 19 Pages: 409-409

    • DOI

      10.1186/s13063-018-2810-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ischemic gastropathy after distal pancreatectomy with en bloc celiac axis resection for pancreatic body cancer.2018

    • Author(s)
      Okada KI, Kawai M, Hirono S, Miyazawa M, Kitahata Y, Ueno M, Hayami S, Shimokawa T, Yamaue H.
    • Journal Title

      Langenbecks Arch Surg.

      Volume: 403 Pages: 561-571

    • DOI

      10.1007/s00423-018-1692-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of developing better practices at the institutional level on surgical outcomes after distal pancreatectomy in 1515 patients: Domestic audit of the Japanese Society of Pancreatic Surgery.2018

    • Author(s)
      Satoi S, Yamamoto T, Motoi F, Matsumoto I, Yoshitomi H, Amano R, Tahara M, Murakami Y, Arimitsu H, Hirono S, Sho M, Ryota H, Ohtsuka M, Unno M, Takeyama Y, Yamaue H.
    • Journal Title

      Ann Gastroenterol Surg.

      Volume: 25 Pages: 212-219

    • DOI

      10.1002/ags3.12066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of HBV integration patterns and timing in liver cancer and HBV-infected livers.2018

    • Author(s)
      Furuta M, Tanaka H, Shiraishi Y, Unida T, Imamura M, Fujimoto A, Fujita M, Sasaki-Oku A, Maejima K, Nakano K, Kawakami Y, Arihiro K, Aikata H, Ueno M, Hayami S, Ariizumi SI, Yamamoto M, Gotoh K, Ohdan H, Yamaue H, Miyano S, Chayama K, Nakagawa H.
    • Journal Title

      Oncotarget.

      Volume: 9 Pages: 25075-25088

    • DOI

      10.18632/oncotarget.25308

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase I/II Trial of Chemotherapy with Docetaxel, Cisplatin, and S-1 for Unresectable Advanced Squamous Cell Carcinoma of the Esophagus.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Katsuda M, Hayata K, Maruoka S, Shimokawa T, Yamaue H.
    • Journal Title

      Oncology.

      Volume: 95 Pages: 116-120

    • DOI

      10.1159/000488861

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fundoplication with 180-Degree Wrap During Esophagogastrostomy After Robotic Proximal Gastrectomy for Early Gastric Cancer.2018

    • Author(s)
      Ojima T, Nakamori M, Nakamura M, Hayata K, Maruoka S, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 1475-1476

    • DOI

      10.1007/s11605-018-3765-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Artery-first approach for pancreaticoduodenectomy.2018

    • Author(s)
      Kawai M, Hirano S, Yamaue H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 25 Pages: 319-320

    • DOI

      10.1002/jhbp.554

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I/Ib study of OTSGC-A24 combined peptide vaccine in advanced gastric cancer.2018

    • Author(s)
      Sunder R et al.
    • Journal Title

      BMC Cancer.

      Volume: 27 Pages: 332-332

    • DOI

      10.1186/s12885-018-4234-8

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pelvic Drain After Laparoscopic Low Anterior Resection for Rectal Cancer in Patients With Diverting Stoma.2018

    • Author(s)
      Matsuda K, Yokoyama S, Hotta T, Watanabe T, Tamura K, Iwamoto H, Mizumoto Y, Yamaue H.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: 28 Pages: 82-85

    • DOI

      10.1097/sle.0000000000000517

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer Vaccine Therapy Using Carcinoembryonic Antigen - expressing Dendritic Cells generated from Induced Pluripotent Stem Cells.2018

    • Author(s)
      Kitadani Junya、Ojima Toshiyasu、Iwamoto Hiromitsu、Tabata Hirotaka、Nakamori Mikihito、Nakamura Masaki、Hayata Keiji、Katsuda Masahiro、Miyajima Masayasu、Yamaue Hiroki
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 4569-4569

    • DOI

      10.1038/s41598-018-23120-z

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laparoscopic and Endoscopic Cooperative Surgery Versus Endoscopic Submucosal Dissection for the Treatment of Low-Risk Tumors of the Duodenum.2018

    • Author(s)
      Ojima T, Nakamori M, Nakamura M, Hayata K, Katsuda M, Takifuji K, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 935-940

    • DOI

      10.1007/s11605-018-3680-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of Internal Hernia During Robotic Total Gastrectomy for Gastric Cancer.2018

    • Author(s)
      Ojima T, Nakamura M, Nakamori M, Hayata K, Katsuda M, Tsuji T, Maruoka S, Yamaue H.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 934-934

    • DOI

      10.1007/s11605-018-3678-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prospective validation of patient fatigue questionnaire (FACIT-F) for fatigue assessment in nab-paclitaxel plus gemcitabine therapy.2018

    • Author(s)
      Okada Ken-Ichi、Hirono Seiko、Kawai Manabu、Miyazawa Motoki、Shimizu Atsushi、Kitahata Yuji、Ueno Masaki、Hayami Shinya、Shimokawa Toshio、Yamaue Hiroki
    • Journal Title

      Mol Clin Oncol.

      Volume: - Pages: 121-126

    • DOI

      10.3892/mco.2017.1485

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indocyanine green fluorescence imaging techniques and interventional radiology during laparoscopic anatomical liver resection (with video).2018

    • Author(s)
      Ueno Masaki、Hayami Shinya、Sonomura Tetsuo、Tanaka Ryota、Kawai Manabu、Hirono Seiko、Okada Ken-ichi、Yamaue Hiroki
    • Journal Title

      Surgical Endoscopy

      Volume: 32 Pages: 1051-1055

    • DOI

      10.1007/s00464-017-5997-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful removal of an internal pancreatic stent that migrated into the bile duct using double-balloon enteroscopy after pancreaticoduodenectomy.2018

    • Author(s)
      Hirono S, Kawai M, Yamashita Y, Okada KI, Miyazawa M, Ueno M, Maeda Y, Itonaga M, Kitano M, Yamaue H.
    • Journal Title

      Surg Today.

      Volume: 48 Pages: 167-174

    • DOI

      10.1007/s00595-017-1563-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CEACAM1 is associated with recurrence after hepatectomy for colorectal liver metastasis.2017

    • Author(s)
      Yamaguchi S, Yokoyama S, Ueno M, Hayami S, Mitani Y, Takeuchi A, Shively JE, Yamaue H.
    • Journal Title

      Journal of Surgical Research

      Volume: 220 Pages: 353-362

    • DOI

      10.1016/j.jss.2017.07.035

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Is distal pancreatectomy with en-bloc celiac axis resection effective for patients with locally advanced pancreatic ductal adenocarcinoma? -Multicenter surgical group study.2017

    • Author(s)
      Yamamoto T, Satoi S, Kawai M, Motoi F, Sho M, Uemura KI, Matsumoto I, Honda G, Okada KI, Akahori T, Toyama H, Kurata M, Yanagimoto H, Yamaue H, Unno M, Kon M, Murakami Y.
    • Journal Title

      Pancreatology.

      Volume: 18 Pages: 106-113

    • DOI

      10.1016/j.pan.2017.11.005

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reinforced staplers for distal pancreatectomy.2017

    • Author(s)
      Kawai M, Hirono S, Okada KI, Satoi S, Yanagimoto H, Kon M, Murakami Y, Kondo N, Sho M, Akahori T, Toyama H, Fukumoto T, Fujii T, Matsumoto I, Eguchi H, Ikoma H, Takeda Y, Fujimoto J, Yamaue H.
    • Journal Title

      Langenbecks Arch Surg.

      Volume: 402 Pages: 1197-1204

    • DOI

      10.1007/s00423-017-1634-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Left Gastric Artery Reconstruction after Distal Pancreatectomy with Celiac Axis En-Bloc Resection: How We Do It.2017

    • Author(s)
      Okada KI, Hirono S, Kawai M, Hayami S, Asamura S, Wada Y, Ueno M, Miyazawa M, Shimizu A, Kitahata Y, Yamaue H.
    • Journal Title

      Gastrointest Tumors.

      Volume: 4 Pages: 28-35

    • DOI

      10.1159/000469660

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative Visceral Tissue Edema Assessed by Computed Tomography Is a Predictor for Severe Complications After Pancreaticoduodenectomy.2017

    • Author(s)
      Shimizu Atsushi、Kawai Manabu、Hirono Seiko、Okada Ken-ichi、Miyazawa Motoki、Kitahata Yuji、Ueno Masaki、Hayami Shinya、Miyamoto Atsushi、Kimoto Yoshiki、Shimokawa Toshio、Yamaue Hiroki
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Pages: 77-87

    • DOI

      10.1007/s11605-017-3608-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implications of carcinoembryonic antigen distribution in serum exosomal fraction-Measurement by ELISA.2017

    • Author(s)
      Yokoyama S, Takeuchi A, Yamaguchi S, Mitani Y, Watanabe T, Matsuda K, Hotta T, Shively JE, Yamaue H.
    • Journal Title

      PLoS One.

      Volume: 12

    • DOI

      10.1371/journal.pone.0183337

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Developing better practices at the institutional level leads to better outcomes after pancreaticoduodenectomy in 3,378 patients: domestic audit of the Japanese Society of Pancreatic Surgery.2017

    • Author(s)
      Satoi S, Yamamoto T, Yoshitomi H, Motoi F, Kawai M, Fujii T, Wada K, Arimitsu H, Sho M, Matsumoto I, Hirano S, Yanagimoto H, Ohtsuka M, Unno M, Yamaue H, Kon M.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Pages: 501-510

    • DOI

      10.1002/jhbp.492

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Neoadjuvant Nab-Paclitaxel plus Gemcitabine Therapy on Overall Survival in Patients with Borderline Resectable Pancreatic Cancer: A Prospective Multicenter Phase II Trial (NAC-GA Trial).2017

    • Author(s)
      Okada Ken-ichi、Shimokawa Toshio、Hirono Seiko、Kawai Manabu、Sho Masayuki、Satoi Sohei、Matsumoto Ippei、Eguchi Hidetoshi、Murakami Yoshiaki、Yamada Suguru、Doi Mariko、Yamaue Hiroki、the NAC-GA investigators
    • Journal Title

      Oncology.

      Volume: 93 Pages: 343-346

    • DOI

      10.1159/000478660

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retrospective Study of the Correlation Between Pathological Tumor Size and Survival After Curative Resection of T3 Pancreatic Adenocarcinoma: Proposal for Reclassification of the Tumor Extending Beyond the Pancreas Based on Tumor Size.2017

    • Author(s)
      Kurata M, Honda G, Murakami Y, Uemura K, Satoi S, Motoi F, Sho M, Matsumoto I, Kawai M, Yanagimoto H, Fukumoto T, Nagai M, Gosho M, Unno M, Yamaue H; Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS).
    • Journal Title

      World J Surg.

      Volume: 48 Pages: 2867-2875

    • DOI

      10.1007/s00268-017-4077-5

    • NAID

      120006365560

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] iPS細胞由来樹状細胞を用いたテーラーメード癌ワクチン療法の現状と未来2018

    • Author(s)
      尾島敏康 岩本博光 北谷純也 田端宏尭 出口真彰 中森幹人 中村公紀 勝田将裕 早田啓治 丸岡慎平 山上裕機
    • Organizer
      第31回日本バイオセラピー学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cancer vaccine therapy using iPS-derived dendritic cells Second Department of Surgery, Wakayama medical university, school of medicine2018

    • Author(s)
      尾島敏康 岩本博光 北谷純也 田端宏尭 出口真彰 中森幹人 中村公紀 勝田将裕 早田啓治 丸岡慎平 山上裕機
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] iPS細胞由来樹状細胞を用いた癌ワクチン療法2018

    • Author(s)
      尾島敏康 岩本博光 北谷純也 田端宏尭  出口真彰 中森幹人 中村公紀 勝田将裕  早田啓治 山上裕機
    • Organizer
      第118回日本外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] iPS細胞由来樹状細胞を用いた テーラーメード癌ワクチン療法2018

    • Author(s)
      尾島敏康 岩本博光 北谷純也 田端宏尭 出口真彰 山上裕機
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cancer vaccine therapy using iPS-derived dendritic cells2017

    • Author(s)
      尾島敏康 岩本博光 北谷純也 田端宏尭  出口真彰 中森幹人 中村公紀 勝田将裕  早田啓治 山上裕機
    • Organizer
      第30回日本バイオセラピー学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Cancer Vaccine Therapy using iPS-derived Dendritic Cells2017

    • Author(s)
      尾島敏康
    • Organizer
      第28回日本消化器癌発生学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Feasibility of Cancer Vaccine Therapy using Dendritic Cells Generated from Induced Pluripotent Stem Cells Expressing Carcinoembryonic Antigen2017

    • Author(s)
      Toshiyasu Ojima, Junya Kitadani, Hiromitsu Iwamoto, Mikihito Nakamori, Masaki Nakamura, and Hiroki Yamaue
    • Organizer
      ASCO 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2017-04-28   Modified: 2021-01-27  

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