| Budget Amount *help |
¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
Fiscal Year 2019: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2018: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2017: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
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| Outline of Final Research Achievements |
In this study, we have developed a compact durable ECMO system. A disposable blood circuit of this system consists of a novel centrifugal blood pump with hydrodynamic bearings, a compact oxygenator with polymethylpentene membrane and manifold built-in monitors. The entire blood-contacting surface of the circuit was treated with a potent heparin bonding material. A pump motor and measurement instruments were integrated into a driver with extremely compact size and lightweight. The final prototype of the ECMO system was evaluated in various safety tests, basic performance experiments and a series of chronic animal experiments. In the chronic animal experiments, veno-arterial bypass ECMO was conducted in adult goats for up to 4 weeks. ECMO could run for scheduled periods without device exchange in all cases. We carried out the preparations of clinical trial by drawing a protocol and providing education/training. The clinical trial of the ECMO system was started at the final fiscal year.
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