| Project/Area Number |
17H01601
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐伯 万騎男 新潟大学, 医歯学系, 教授 (30273692)
前田 健康 新潟大学, 医歯学系, 教授 (40183941)
川崎 真依子 新潟大学, 医歯学系, 准教授 (40584587)
泉 健次 新潟大学, 医歯学系, 教授 (80242436)
齊藤 一誠 新潟大学, 医歯学系, 准教授 (90404540)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥43,030,000 (Direct Cost: ¥33,100,000、Indirect Cost: ¥9,930,000)
Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2018: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2017: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
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| Keywords | 幹細胞 / 再生 |
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| Outline of Final Research Achievements |
Regenerative therapy requires induction of stem cells to target cells. However, regulatory mechanism inducing target tissue-forming cells from stem cells should be elucidated for that purpose. Organ development is achieved by the differentiation of stem cells. We identified molecular mechanism of regulating stem cells in the tongue and palate development. Moreover, we found that Ofd1 (primary cilia protein) in mesenchymal cells control differentiation of tongue-forming cells during tongue development, suggesting the possibility that the primary cilia indirectly regulate stem cell differentiation.
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| Academic Significance and Societal Importance of the Research Achievements |
再生療法には、幹細胞の制御メカニズムの解明が必須である。体が作られる発生時における知見が、その解明の鍵となる。本研究での成果は、器官発生時における制御メカニズムであり、再生療法確立に大きく貢献できると考えられる。さらに、一次線毛の機能不全は、繊毛病という疾患を引き起こす。本研究の成果は、繊毛病に対しての治療法開発などにも結びつく。
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