Analyzing a relationship between a diffusion of pathogenic microorganisms in river water and occurrences of infectious disease in Zambia
Project/Area Number |
17H01679
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 海外学術 |
Research Field |
Veterinary medical science
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Research Institution | Hokkaido University |
Principal Investigator |
Higashi Hideaki 北海道大学, 人獣共通感染症リサーチセンター, 教授 (20311227)
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Co-Investigator(Kenkyū-buntansha) |
稲葉 愛美 東京大学, 大学院新領域創成科学研究科, 客員共同研究員 (60749448)
愛知 正温 東京大学, 大学院新領域創成科学研究科, 講師 (40645917)
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Project Period (FY) |
2017-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2019: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2018: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2017: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
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Keywords | 感染症 / 伝播経路 / 細菌感染 / 病原体 / 拡散モデル |
Outline of Final Research Achievements |
To elucidate the transmission system of zoonotic pathogens in Zambia, we focused on anthrax spores in river water and attempted to reveal the waterborne transmission of the pathogen. In the Luangwa River basin, where anthrax outbreaks have been occurring repeatedly, river water samples were collected by the anthrax spore enrichment method developed in this study. By using PCR and next-generation sequencing, the presence of anthrax in the river water was demonstrated. Additionally, we also found the presence of enteroviruses in the river water. Furthermore, environmental information such as river water depth, temperature, turbidity and flow rate were measured at the sampling sites, and a model of pathogen diffusion by river water was constructed.
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Academic Significance and Societal Importance of the Research Achievements |
環境耐性が高い芽胞を形成する細菌を用いた拡散モデルの構築は、長距離区間の拡散・到達率、及び疾病発生起点からの汚染レベルを解明する上で重要な情報となりえる。現在、日本国内において炭疽は沈静化を見せているが、土壌中の残存芽胞により再興感染症として流行すること、及びバイオテロリズムとして芽胞の散布・拡散に河川流水が利用される可能性は否定できない。本研究で得られた結果は、炭疽菌をはじめとした病原体の伝播拡散への対策を進めていく際の基礎データとなるものである。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] A potential role of non-neutralizing IgA antibodies in cross-protective immunity against influenza A viruses of multiple hemagglutinin subtypes2020
Author(s)
Okuya K, Yoshida R, Manzoor R, Saito S, Suzuki T, Sasaki M, Saito T, Kida Y, Mori-Kajihara A, Kondoh T, Sato M, Kajihara M, Miyamoto H, Ichii O, Higashi H, Takada A
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Journal Title
J Virol
Volume: -
Issue: 12
Pages: 408-420
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Novel Sequence Type in Bacillus cereus Strains Associated with Nosocomial Infections and Bacteremia, Japan.2019
Author(s)
Akamatsu R, Suzuki M, Okinaka K, Sasahara T, Yamane K, Suzuki S, Fujikura D, Furuta Y, Ohnishi N, Esaki M, Shibayama K, Higashi H
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Journal Title
Emerging Infectious Diseases
Volume: 25(5)
Issue: 5
Pages: 883-890
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A novel sequence type in Bacillus cereus strains associated with nosocomial infections and bacteremia in Japan2019
Author(s)
Akamatsu R, Suzuki M, Okinaka K, Sasahara T, Yamane K, Suzuki S, Fujikura D, Furuta Y, Ohnishi N, Esaki M, Shibayama K, Higashi H
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Journal Title
Emerg Infect Dis
Volume: 印刷中
Related Report
Peer Reviewed
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[Presentation] Research activities at Hokudai Center for Zoonosis Control in Zambia2017
Author(s)
Hideaki Higashi, Qiu Yongjin, Ami Soda, Yasuhiko Suzuki, Chihiro Sugimoto, Ayato Takada, Kimihito Ito, Hiroshi Kida, Hirofumi Sawa
Organizer
2nd International Joint Symposium: Promotion of Infectious Disease Research Cooperation between Africa and Japan toward Science, Technology and Innovation
Related Report
Int'l Joint Research / Invited