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Analyzing a relationship between a diffusion of pathogenic microorganisms in river water and occurrences of infectious disease in Zambia

Research Project

Project/Area Number 17H01679
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Veterinary medical science
Research InstitutionHokkaido University

Principal Investigator

Higashi Hideaki  北海道大学, 人獣共通感染症リサーチセンター, 教授 (20311227)

Co-Investigator(Kenkyū-buntansha) 稲葉 愛美  東京大学, 大学院新領域創成科学研究科, 客員共同研究員 (60749448)
愛知 正温  東京大学, 大学院新領域創成科学研究科, 講師 (40645917)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2019: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2018: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2017: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Keywords感染症 / 伝播経路 / 細菌感染 / 病原体 / 拡散モデル
Outline of Final Research Achievements

To elucidate the transmission system of zoonotic pathogens in Zambia, we focused on anthrax spores in river water and attempted to reveal the waterborne transmission of the pathogen. In the Luangwa River basin, where anthrax outbreaks have been occurring repeatedly, river water samples were collected by the anthrax spore enrichment method developed in this study. By using PCR and next-generation sequencing, the presence of anthrax in the river water was demonstrated. Additionally, we also found the presence of enteroviruses in the river water. Furthermore, environmental information such as river water depth, temperature, turbidity and flow rate were measured at the sampling sites, and a model of pathogen diffusion by river water was constructed.

Academic Significance and Societal Importance of the Research Achievements

環境耐性が高い芽胞を形成する細菌を用いた拡散モデルの構築は、長距離区間の拡散・到達率、及び疾病発生起点からの汚染レベルを解明する上で重要な情報となりえる。現在、日本国内において炭疽は沈静化を見せているが、土壌中の残存芽胞により再興感染症として流行すること、及びバイオテロリズムとして芽胞の散布・拡散に河川流水が利用される可能性は否定できない。本研究で得られた結果は、炭疽菌をはじめとした病原体の伝播拡散への対策を進めていく際の基礎データとなるものである。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (23 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (3 results) Journal Article (12 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 12 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results)

  • [Int'l Joint Research] ザンビア大学獣医学部/ザンビア観光省/ザンビア農業省(ザンビア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ザンビア大学獣医学部/ザンビア保健省/ザンビア観光省(ザンビア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ザンビア大学/ザンビア保健省/ザンビア観光省(ザンビア)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] A potential role of non-neutralizing IgA antibodies in cross-protective immunity against influenza A viruses of multiple hemagglutinin subtypes2020

    • Author(s)
      Okuya K, Yoshida R, Manzoor R, Saito S, Suzuki T, Sasaki M, Saito T, Kida Y, Mori-Kajihara A, Kondoh T, Sato M, Kajihara M, Miyamoto H, Ichii O, Higashi H, Takada A
    • Journal Title

      J Virol

      Volume: - Issue: 12 Pages: 408-420

    • DOI

      10.1128/jvi.00408-20

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Geographic distribution of cattle anthrax in Western Zambia2019

    • Author(s)
      Simbotwe M, Mulenga E, Furuta Y, Muuka GM, Hang’ombe BM, Higashi H
    • Journal Title

      JJVR

      Volume: 67 Pages: 195-202

    • NAID

      120006648364

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in Bacillus anthracis2019

    • Author(s)
      Toyomane K, Furuta Y, Fujikura D, Higashi H
    • Journal Title

      PeerJ

      Volume: 7 Pages: e6718-e6718

    • DOI

      10.7717/peerj.6718

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel Sequence Type in Bacillus cereus Strains Associated with Nosocomial Infections and Bacteremia, Japan.2019

    • Author(s)
      Akamatsu R, Suzuki M, Okinaka K, Sasahara T, Yamane K, Suzuki S, Fujikura D, Furuta Y, Ohnishi N, Esaki M, Shibayama K, Higashi H
    • Journal Title

      Emerging Infectious Diseases

      Volume: 25(5) Issue: 5 Pages: 883-890

    • DOI

      10.3201/eid2505.171890

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Caspase-3 knockout inhibits intervertebral disc degeneration related to injury but accelerates degeneration related to aging2019

    • Author(s)
      Ohnishi T, Yamada K, Iwasaki K, Tsujimoto T, Higashi H, Kimura T, Iwasaki N, Sudo H
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 19324-19324

    • DOI

      10.1038/s41598-019-55709-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Geographic distribution of cattle anthrax in Western Zambia2019

    • Author(s)
      Simbotwe M, Mulenga E, Furuta Y, Muuka GM, Hang’ombe BM, Higashi H.
    • Journal Title

      JJVR

      Volume: 印刷中

    • NAID

      120006648364

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A novel sequence type in Bacillus cereus strains associated with nosocomial infections and bacteremia in Japan2019

    • Author(s)
      Akamatsu R, Suzuki M, Okinaka K, Sasahara T, Yamane K, Suzuki S, Fujikura D, Furuta Y, Ohnishi N, Esaki M, Shibayama K, Higashi H
    • Journal Title

      Emerg Infect Dis

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of Bacitracin Resistance Due to a Large Genomic Deletion among Bacillus anthracis Strains2018

    • Author(s)
      Furuta Y, Harima H, Ito E, Maruyama F, Ohnishi N, Osaki K, Ogawa H, Squarre D, Hang'ombe BM, Higashi H
    • Journal Title

      mSystems

      Volume: 3 Issue: 5 Pages: 00182-18

    • DOI

      10.1128/msystems.00182-18

    • NAID

      120006543305

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development and application of a Bacillus anthracis protective antigen domain-1 in-house ELISA for the detection of anti-protective antigen antibodies in cattle in Zambia2018

    • Author(s)
      Simbotwe Manyando、Fujikura Daisuke、Ohnuma Miyuki、Omori Ryosuke、Furuta Yoshikazu、Muuka Geoffrey Munkombwe、Hang’ombe Bernard Mudenda、Higashi Hideaki
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 10 Pages: e0205986-e0205986

    • DOI

      10.1371/journal.pone.0205986

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Death receptor 6 contributes to autoimmunity in lupus-prone mice.2017

    • Author(s)
      Fujikura D, Ikesue M, Endo T, Chiba S, Higashi H and Uede T
    • Journal Title

      Nature Communications

      Volume: 8:13957 Issue: 1 Pages: 1-11

    • DOI

      10.1038/ncomms13957

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection2017

    • Author(s)
      Fujikura Daisuke、Muramatsu Daisuke、Toyomane Kochi、Chiba Satoko、Daito Takuji、Iwai Atsushi、Kouwaki Takahisa、Okamoto Masaaki、Higashi Hideaki、Kida Hiroshi、Oshiumi Hiroyuki
    • Journal Title

      The Journal of Biochemistry

      Volume: 163 Issue: 1 Pages: 31-38

    • DOI

      10.1093/jb/mvx062

    • NAID

      40021457359

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum)2017

    • Author(s)
      Ogawa Hirohito、Kajihara Masahiro、Nao Naganori、Shigeno Asako、Fujikura Daisuke、Hang’ombe Bernard、Mweene Aaron、Mutemwa Alisheke、Squarre David、Yamada Masao、Higashi Hideaki、Sawa Hirofumi、Takada Ayato
    • Journal Title

      Viruses

      Volume: 9 Issue: 12 Pages: 371-371

    • DOI

      10.3390/v9120371

    • NAID

      120006382305

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Candidatus Borrelia fainii ~a new world relapsing fever borrelia in Zambia~2020

    • Author(s)
      Yongjin Qiu, Hideaki Higashi
    • Organizer
      Joint symposium for the control of zoonoses in Zambia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 炭疽の現状と予防対策2020

    • Author(s)
      東 秀明
    • Organizer
      第93回日本細菌学会総会 シンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Research Center for Zoonosis Control and Hokudai Center for Zoonosis Control in Zambia2019

    • Author(s)
      Hideaki HIGASHI
    • Organizer
      新興・再興感染症に関するアジア・アフリカ リサーチフォーラム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 人獣共通感染症の克服を目指して -アフリカにおける炭疽の現状-2018

    • Author(s)
      東 秀明
    • Organizer
      第27回先端科学移動大学2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 途上国における炭疽の現状と予防対策2018

    • Author(s)
      東 秀明
    • Organizer
      第63回日本ブドウ球菌研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 炭疽菌感染の現状と予防対策2018

    • Author(s)
      東 秀明
    • Organizer
      日本実験動物学会第7回実験動物科学シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 炭疽 -現状と新たな予防法への取組み-2018

    • Author(s)
      東 秀明
    • Organizer
      琉球大学熱帯生物圏研究センターセミナー
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Research activities at Hokudai Center for Zoonosis Control in Zambia2017

    • Author(s)
      Hideaki Higashi, Qiu Yongjin, Ami Soda, Yasuhiko Suzuki, Chihiro Sugimoto, Ayato Takada, Kimihito Ito, Hiroshi Kida, Hirofumi Sawa
    • Organizer
      2nd International Joint Symposium: Promotion of Infectious Disease Research Cooperation between Africa and Japan toward Science, Technology and Innovation
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2017-04-28   Modified: 2021-02-19  

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