| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
In contrast to the accumulation of information on molecules important for organ morphogenesis, physical processes such as tissue deformation, cell collective motion, and their involvement in mechanics remain unresolved for most organs. In this study, we performed high resolution 4D imaging of early heart development (specifically, C-looping process) and quantitative analysis of tissue and cell dynamics from cell trajectory data. We found left-right asymmetric dynamics within the heart tube at both cellular and tissue levels. We also performed mechanical simulations based on the constitutive laws assumed from the results of data analysis, and succeeded in reproducing the initial morphological changes. These results were published in Cell Reports [Kawahira et al., Cell Rep., 2020].
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