| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2021: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
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| Outline of Final Research Achievements |
Quality control of the genome and proteome in the cell nucleus of eukaryotic cells, including humans, is closely related to cell fate determination and cell death. It is important to understand the basis of their molecular regulation. Protein network regulation, including post-translational modifications of proteins, is one of the molecular regulatory bases. In the early stages of this study, we focused on SUMOylation among post-translational modifications, but later we expanded our analysis to broad aspects of cellular components, including genome, protein as well as phospholipid membrane. As a result, multiple experimental systems have been set up to determine how human cells initiate molecular responses to the internal and external environment, providing insights into multiple signaling regulatory systems in human cells.
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