| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
Bisphenol A is a raw material of polycarbonate and epoxy resins. This chemical is also known as a harmful environmental chemical, which shows adverse effects even at low doses. The target molecules of environmental chemicals are thought to be nuclear receptors which control gene transcriptions. We have found that the transcriptional activity of an estrogen receptor, which belongs to nuclear receptors, are synergistically increased by co-expression with other nuclear receptors. The aim of this study is to clarify the molecular mechanisms underlying the synergistic effect on transcriptional activity. Finally, we found that several next generation bisphenols bind to the estrogen receptor stronger than bisphenol A.
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