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Acute and medium- to long-term effects of Asian dust and air pollutants on allergies and biomarker search

Research Project

Project/Area Number 17H01886
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental impact assessment
Research InstitutionKanazawa University

Principal Investigator

Higashi Tomomi  金沢大学, 医学系, 助教 (20293342)

Co-Investigator(Kenkyū-buntansha) 上野 貴雄  金沢大学, 附属病院, 助教 (30623649)
原 丈介  金沢大学, 医薬保健学総合研究科, 特任准教授 (30710199)
高原 志津子  金沢大学, 附属病院, 特任助教 (60446755)
今井 康人  金沢大学, 附属病院, 特任教授 (60720878)
藤村 政樹  金沢大学, 医学系, 協力研究員 (90190066)
西條 清史  金沢大学, 医学系, 教授 (00178469)
Project Period (FY) 2017-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords黄砂 / PM2.5 / アレルギー / 臨床疫学 / スギ花粉 / 慢性咳嗽 / PM2.5 / 喘息 / 大気環境 / 健康影響
Outline of Final Research Achievements

In this study, we continued the patient epidemiological survey conducted by the principal investigators on changes in symptoms of allergic patients due to air pollutants such as Asian dust and PM2.5, and the acute effects of exposure to air pollutants. At the same time, we investigated the medium- to long-term effects. As a result of analyzing the effect of Asian dust on the symptoms of patients with cedar pollinosis, the symptoms of itchy eyes were found to be related to the scattering of cedar pollen and Asian dust, respectively, and an interaction was also observed. The higher the concentration of PM2.5, the higher the risk of nasal congestion, but the interaction of Asian dust was hardly observed. No significant relationship was found regarding the effect of Asian dust on the symptoms of respiratory medicine patients in each year.

Academic Significance and Societal Importance of the Research Achievements

本研究によって得られた大気情報と患者さんの臨床情報、症状記録の時系列データベースは、異分野協働の成果であり、さらに10年分の継続データは国内外ともに同類のものが無く、新しい知見を見出すための情報として意義深いものとなった。また、研究期間中に発生した新型コロナウイルス感染拡大による緊急自粛期間には、PM2.5の濃度低下などこれまでに見られない新しいデータも取得できており、今後完成したデータベースをもとにさまざまな視点からの詳細な解析を行うことが可能である。社会的には、スギ花粉と黄砂の同時曝露の影響について関心が高く患者さんも多いことから、交互作用の存在を明らかにしたことは意義深い知見となった。

Report

(6 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (87 results)

All 2022 2021 2020 2019 2018 2017

All Journal Article (47 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 39 results,  Open Access: 15 results) Presentation (39 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] A use-case analysis of Clinical Data Interchange Standards Consortium/Study Data Tabulation Model in academia in an investigator-initiated clinical trial2022

    • Author(s)
      Shizuko Takahara, Toshiki I. Saito, Yasuhito Imai, Takahiro Kawakami, Toshinori Murayama
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 84 Issue: 1 Pages: 120-132

    • DOI

      10.18999/nagjms.84.1.120

    • ISSN
      0027-7622
    • URL

      https://nagoya.repo.nii.ac.jp/records/2002124

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I/II clinical trial of high-dose [131I] meta-iodobenzylguanidine therapy for high-risk neuroblastoma preceding single myeloablative chemotherapy and haematopoietic stem cell transplantation.2022

    • Author(s)
      Kuroda R, Wakabayashi H, Araki R, Inaki A, Nishimura R, Ikawa Y, Yoshimura K, Murayama T, Imai Y, Funasaka T, Wada T, Kinuya S.
    • Journal Title

      Eur J Nucl Med Mol Imaging,

      Volume: in press Issue: 5 Pages: 1574-1583

    • DOI

      10.1007/s00259-021-05630-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 人工知能(AI)によるHAT(Health Age Trust)システム構築における介護スタッフの業務効率化向上に関するアンケート調査研究、2022

    • Author(s)
      今井康人、杉本修治、山崎章子、大嶋三郎、古川仭、村山敏典、金子周一
    • Journal Title

      未病学会

      Volume: 28 Pages: 31-41

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Chest Dynamic-Ventilatory Digital Radiography in Chronic Obstructive or Restrictive Lung Disease.2021

    • Author(s)
      Ohkura N, Tanaka R, Watanabe S, Hara J, Abo M, Nakade Y, Horii J, Matsuura Y, Inoue D, Takata M, Tamura M, Matsumoto I, Sanada S, Kasahara K.
    • Journal Title

      Int J Chron Obstruct Pulmon Dis.

      Volume: 16 Pages: 1393-1399

    • DOI

      10.2147/copd.s309960

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fractional analysis of bronchoalveolar lavage in systemic sclerosis-associated interstitial lung disease.2021

    • Author(s)
      Kase K, Watanabe S, Saeki K, Waseda Y, Takato H, Ichikawa Y, Murata A, Yasui M, Noriyuki O, Hara J, Sone T, Abo M, Kimura H, Kasahara K.
    • Journal Title

      J Thorac Dis

      Volume: 13 Issue: 7 Pages: 4146-4155

    • DOI

      10.21037/jtd-20-2596

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two cases of chronic obstructive pulmonary disease evaluated by dynamic-ventilatory digital radiography for pulmonary function and assessment of treatment efficacy.2021

    • Author(s)
      Ohkura N, Tanaka R, Hara J, Ogawa N, Abo M, Watanabe S, Tambo Y, Nishikawa S, Sone T, Kimura H, Kasahara K.
    • Journal Title

      Respir Investig

      Volume: 59 Issue: 6 Pages: 871-875

    • DOI

      10.1016/j.resinv.2021.07.005

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of serum periostin level as a predictor of requirement for intensive treatment for type-2 inflammation in asthmatics in future: A follow-up study of the KiHAC cohort2021

    • Author(s)
      Sunadome H, Matsumoto H, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Iwanaga T, Hozawa S, Niimi A, Kanemitsu Y, Nagasaki T, Tashima N, Ishiyama Y, Morimoto C, Oguma T, Tajiri T, Ito I, Ono J, Ohta S, Izuhara K, Hirai T.
    • Journal Title

      Allergology International

      Volume: 70 Issue: 2 Pages: 252-254

    • DOI

      10.1016/j.alit.2020.10.006

    • NAID

      130008024341

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epstein?Barr Virus LMP1 Induces Soluble PD-L1 in Nasopharyngeal Carcinoma2021

    • Author(s)
      Kase Kina、Kondo Satoru、Wakisaka Naohiro、Dochi Hirotomo、Mizokami Harue、Kobayashi Eiji、Kano Makoto、Komori Takeshi、Hirai Nobuyuki、Ueno Takayoshi、Nakanishi Yosuke、Hatano Miyako、Endo Kazuhira、Moriyama-Kita Makiko、Sugimoto Hisashi、Yoshizaki Tomokazu
    • Journal Title

      Microorganisms

      Volume: 9 Issue: 3 Pages: 603-603

    • DOI

      10.3390/microorganisms9030603

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Xenografts derived from patients with head and neck cancer recapitulate patient tumour properties2021

    • Author(s)
      Makita Haruna、Endo Kazuhira、Kasahara Yoshiya、Nakata Asuka、Moriyama?kita Makiko?、Ishikawa Kazuya、Ueno Takayoshi、Nakanishi Yosuke、Kondo Satoru、Wakisaka Naohiro、Gotoh Noriko、Yoshizaki Tomokazu
    • Journal Title

      Oncology Letters

      Volume: 21 Issue: 5 Pages: 385-385

    • DOI

      10.3892/ol.2021.12646

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serum laminin γ2 monomer as a novel diagnostic and predictive biomarker for hepatocellular carcinoma.2021

    • Author(s)
      T Yamashita, N Koshikawa, T Shimakami, T Terashima, M Nakagawa, K Nio, R Horii, N Iida, K Kawaguchi, K Arai, Y Sakai, T Yamashita, E Mizukoshi, M Honda, A Kitao, S Kobayashi, S Takahara, Y Imai, K Yoshimura, T Murayama, Y Nakamoto, E Yoshida, T Yoshimura, M Seiki, S Kaneko.
    • Journal Title

      Hepatology

      Volume: - Issue: 2 Pages: 760-775

    • DOI

      10.1002/hep.31758

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy2021

    • Author(s)
      Sakai Y, Fukunishi S, Takamura M, Kawaguchi K, Inoue O, Usui S, Takashima S, Seki A, Asai A, Tsuchimoto Y, Nasti A, Bich Ho TT, Imai Y, Yoshimura K, Murayama T, Yamashita T, Arai K, Yamashita T, Mizukoshi E, Honda M, Wada T, Harada K, Higuchi K, Kaneko S.
    • Journal Title

      Regenerative Therapy

      Volume: 18 Pages: 97-101

    • DOI

      10.1016/j.reth.2021.04.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Late-onset programmed cell death protein-1 inhibitor-induced pneumonitis after cessation of nivolumab or pembrolizumab in patients with advanced non-small cell lung cancer: a case series2021

    • Author(s)
      Kimura Hideharu、Sone Takashi、Araya Tomoyuki、Murata Akari、Yamamura Kenta、Ohkura Noriyuki、Hara Johsuke、Abo Miki、Kasahara Kazuo
    • Journal Title

      Translational Lung Cancer Research

      Volume: 10 Issue: 3 Pages: 1576-1581

    • DOI

      10.21037/tlcr-20-582

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular features of tumor-derived genetic alterations in circulating cell-free DNA in virtue of autopsy analysis2021

    • Author(s)
      Koba Hayato、Kimura Hideharu、Yoneda Taro、Sone Takashi、Ohkura Noriyuki、Hara Johsuke、Hosomichi Kazuyoshi、Tajima Atsushi、Kasahara Kazuo
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 8398-8398

    • DOI

      10.1038/s41598-021-87094-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 企業との連携円滑化のためのCDISC標準情報共有体制提案のためのアンケート調査2021

    • Author(s)
      山口拓洋, 高原志津子, 齋藤明子, 齋藤俊樹
    • Journal Title

      薬理と治療

      Volume: 49 Pages: 47-56

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新型コロナウイルスワクチンが原因と考えられた薬剤性肺障害の3例2021

    • Author(s)
      渡辺 知志, 清水 崇広, 米田 知晃, 中積 広貴, 加瀬 一政, 武田 仁浩, 丹保 裕一, 大倉 徳幸, 原 丈介, 阿保 未来, 笠原 寿郎
    • Journal Title

      アレルギー

      Volume: 71 Pages: 66-66

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 気管支平滑筋収縮をトリガーとする咳嗽におけるトロンボキサンA2(TXA2)受容体拮抗薬の影響2021

    • Author(s)
      小川 尚彦, 原 丈介, 大倉 徳幸, 阿保 未来, 笠原 寿郎
    • Journal Title

      アレルギー

      Volume: 70 Pages: 986-986

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 当院における重症喘息患者に対する生物学的製剤の使用状況2021

    • Author(s)
      大倉 徳幸, 原 丈介, 小川 尚彦, 阿保 未来, 古林 崇史, 武田 仁浩, 笠原 寿郎
    • Journal Title

      アレルギー

      Volume: 70 Pages: 853-853

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 気管支喘息(成人) 管理:合併症,COVID-19 当院においてCOPD,ACOに対する初回治療としてトリプル製剤を投与した症例の治療効果2021

    • Author(s)
      小川 尚彦, 原 丈介, 中積 広貴, 古林 崇史, 谷村 航太, 湯浅 瑞希, 加瀬 一政, 武田 仁浩, 寺田 七朗, 渡辺 知志, 丹保 裕一, 大倉 徳幸, 阿保 未来, 木村 英晴, 曽根 崇, 笠原 寿郎
    • Journal Title

      アレルギー

      Volume: 70 Pages: 804-804

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 気管支喘息(成人):フェノタイプ,併存症 喘息COPDオーバラップ病態におけるICS/LABAへのtiotropium追加投与の効果2021

    • Author(s)
      石浦 嘉久, 藤村 政樹, 原 丈介, 大倉 徳幸, 澤井 裕介, 石井 睦康, 玉置 岳史, 清水 俊樹, 野村 昌作
    • Journal Title

      アレルギー

      Volume: 70 Pages: 785-785

    • Related Report
      2021 Annual Research Report
  • [Journal Article] X線動態解析を用いたCOPDの治療効果判定の検討2021

    • Author(s)
      大倉 徳幸, 田中 利恵, 原 丈介, 阿保 未来, 小川 尚彦, 丹保 裕一, 西川 晋吾, 曽根 崇, 木村 英晴, 高田 宗尚, 田村 昌也, 松本 勲, 真田 茂, 笠原 寿郎
    • Journal Title

      日本呼吸器学会誌

      Volume: 10 Pages: 155-155

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 【呼吸器症候群(第3版)-その他の呼吸器疾患を含めて-】閉塞性肺疾患、気管支の異常、嚢胞性肺疾患 閉塞性肺疾患、気管支の異常 ブロンコレアー(気管支漏)2021

    • Author(s)
      原 丈介
    • Journal Title

      日本臨床別冊呼吸器症候群

      Volume: 3 Pages: 122-125

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Phase 1/2 study of alectinib in RET-rearranged previously-treated non-small cell lung cancer (ALL-RET)2021

    • Author(s)
      Takeuchi S, Yanagitani N, Seto T, Hattori Y, Ohashi K, Morise M, Matsumoto S, Yoh K, Goto K, Nishio M, Takahara S, Kawakami T, Imai Y, Yoshimura K, Tanimoto A, Nishiyama A, Murayama T, Yano S.
    • Journal Title

      Transl Lung Cancer Res

      Volume: 10 Pages: 314-325

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum laminin γ2 monomer as a novel diagnostic and predictive biomarker for hepatocellular carcinoma.Hepatology2021

    • Author(s)
      Yamashita Taro, Koshikawa N, Shimakami T, Terashima T, Nakagawa M, Nio K, Horii R, Iida N, Kawaguchi K, Arai K, Sakai Y, Yamashita Tat, Mizukoshi E, Honda M, Kitao A, Kobayashi S, Takahara S, Imai Y, Yoshimura K, Murayama T, Nakamoto Y, Yoshida E, Yoshimura T, Seiki M, Kaneko S
    • Journal Title

      Hepatology

      Volume: in press

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low Skeletal Muscle Mass Is a Risk Factor for Aspiration Pneumonia During Chemoradiotherapy2020

    • Author(s)
      Endo Kazuhira、Ueno Takayoshi、Hirai Nobuyuki、Komori Takeshi、Nakanishi Yosuke、Kondo Satoru、Wakisaka Naohiro、Yoshizaki Tomokazu
    • Journal Title

      The Laryngoscope

      Volume: 131 Issue: 5 Pages: 1524-1529

    • DOI

      10.1002/lary.29165

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acute, medium and long-term effects of yellow sand and air pollutants on allergy and biomarker search2020

    • Author(s)
      T Higashi
    • Journal Title

      Impact

      Volume: 2020 Issue: 3 Pages: 63-65

    • DOI

      10.21820/23987073.2020.3.63

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大気汚染物質の鼻アレルギー症状への影響2020

    • Author(s)
      上野貴雄、東朋美,吉崎智一
    • Journal Title

      アレルギーの臨床

      Volume: 49 Pages: 737-741

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naive guinea pigs2020

    • Author(s)
      Yamamura K, Hara J, Sakai T, Ohkura N, Abo M, Ogawa N, Okazaki A, Sone T, Kimura H, Fujimura M, Nakao S, Kasahara K
    • Journal Title

      Allergol Int

      Volume: 69 Pages: 223-231

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Triple therapy with budesonide/glycopyrrolate/formoterol fumarate improves inspiratory capacity in patients with asthma-chronic obstructive pulmonary disease overlap2020

    • Author(s)
      Ishiura Y, Fujimura M, Ohkura N, Hara J, Kasahara K, Nomura S
    • Journal Title

      Int J Chron Obstruct Pulmon Dis

      Volume: 15 Pages: 269-277

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methacholine-induced cough as an indicator of bronchodilator-responsive cough2020

    • Author(s)
      Ohkura N, Fujimura M, Hara J, Nakade Y, Abo M, Sone T, Kimura H, Kasahara K
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 64 Pages: 101962-101962

    • DOI

      10.1016/j.pupt.2020.101962

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute, medium and long-term effects of yellow sand and air pollutants on allergy and biomarker search2020

    • Author(s)
      Higashi T
    • Journal Title

      Impact

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 大気汚染物質の健康影響評価2019

    • Author(s)
      東 朋美
    • Journal Title

      アレルギーの臨床

      Volume: 39 Pages: 933-937

    • NAID

      40021807825

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Single Institution Retrospective Study of the Clinical Efficacy of Tiotropium Respimat in Never-Smoking Elderly Asthmatics with Irreversible Airflow Limitation.2019

    • Author(s)
      Hara J, Kasahara K, Ohkura N, Yamamura K, Sakai T, Abo M, Ogawa N, Saeki K, Koba H, Watanabe S, Uchida Y, Tambo Y, Sone T, Kimura H.
    • Journal Title

      Drug Res

      Volume: 69 Pages: 211-217

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased Cough Receptor Sensitivity to Capsaicin Predicts a Positive Bronchial Thermoplasty Response: A Single-center Retrospective Study.2019

    • Author(s)
      Yamamura K, Hara J, Ohkura N, Abo M, Sone T, Kimura H, Kasahara K.
    • Journal Title

      J Bronchology Interv Pulmonol.

      Volume: 26 Pages: 137-141

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of EGFR mutation-positive lung adenocarcinoma in which the T790M allele fraction was increased by repeated EGFR-TKI treatment.2019

    • Author(s)
      Kimura H, Amino Y, Koba H, Tambo Y, Ohkura N, Hara J, Sone T, Kasahara K.
    • Journal Title

      Cancer Commun (Lond).

      Volume: 39 Pages: 67-67

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated bronchoconstriction attenuates the cough response to bronchoconstriction in naive guinea pigs2019

    • Author(s)
      Yamamura K, Hara J, Sakai T, Ohkura N, Abo M, Ogawa N, Okazaki A, Sone T, Kimura H, Fujimura M, Nakao S, Kasahara K.
    • Journal Title

      Allergol Int.

      Volume: 19 Pages: 1323-1323

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of triple therapy in patients with asthma-COPD overlap.2019

    • Author(s)
      Ishiura Y, Fujimura M, Ohkura N, Hara J, Kasahara K, Ishii N, Tamaki T, Shimizu T, Nomura S.
    • Journal Title

      Int J Clin Pharmacol Ther.

      Volume: 57 Pages: 384-392

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence and clinical features of asthma-COPD overlap (ACO) definitively diagnosed according to the Japanese Respiratory Society Guidelines for the Management of ACO 2018.2019

    • Author(s)
      Yamamura K, Hara J, Kobayashi T, Ohkura N, Abo M, Akasaki K, Nomura S, Yuasa M, Saeki K, Terada N, Matsuoka H, Tambo Y, Nishikawa S, Sone T, Kimura H, Kasahara K.
    • Journal Title

      J Med Invest

      Volume: 66 Pages: 157-164

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase I clinical trial for [131I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma.2019

    • Author(s)
      Wakabayashi H, Inaki A, Yoshimura K, Murayama T, Imai Y, Higuchi T, Jinguji M, Shiga T, Kinuya S.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 7625-7626

    • DOI

      10.1038/s41598-019-43880-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of novel diagnostic system for pancreatic cancer, including early stages, measuring mRNA of whole blood cells2019

    • Author(s)
      Sakai Yoshio、Honda Masao、Matsui Shigeyuki、Komori Osamu、Murayama Toshinori、Fujiwara Tadami、Mizuno Masaaki、Imai Yasuhito、Yoshimura Kenichi、Nasti Alessandro、Wada Takashi、Iida Noriho、Kitahara Masaaki、Horii Rika、Toshikatsu Tamai、Nishikawa Masashi、Okafuji Hirofumi、Mizukoshi Eishiro、et al
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 4 Pages: 1364-1388

    • DOI

      10.1111/cas.13971

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of sinobronchial syndrome progressing to diffuse panbronchiolitis despite low-dose, long-term macrolide therapy.2018

    • Author(s)
      Abo M, Amino Y, Hara J, Ohkura N, Sone T, Kimura H, Kasahara K
    • Journal Title

      J Thorac Dis

      Volume: 10 Issue: 10 Pages: E727-E729

    • DOI

      10.21037/jtd.2018.09.56

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Next-generation sequencing analysis identifies genomic alterations in pathological morphologies: A case of pulmonary carcinosarcoma harboring EGFR mutations2018

    • Author(s)
      Koba Hayato、Kimura Hideharu、Nishikawa Shingo、Sone Takashi、Abo Miki、Hara Johsuke、Hosomichi Kazuyoshi、Tajima Atsushi、Kasahara Kazuo
    • Journal Title

      Lung Cancer

      Volume: 122 Pages: 146-150

    • DOI

      10.1016/j.lungcan.2018.05.026

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大気汚染物質の健康影響評価2018

    • Author(s)
      東 朋美
    • Journal Title

      アグリバイオ

      Volume: 10 Pages: 47-51

    • NAID

      40021807825

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of prostaglandin E 2 in bronchoconstriction-triggered cough response in guinea pigs2018

    • Author(s)
      Okazaki Akihito、Hara Johsuke、Ohkura Noriyuki、Fujimura Masaki、Sakai Tamami、Abo Miki、Katayama Nobuyuki、Kasahara Kazuo、Nakao Shinji
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 48 Pages: 62-70

    • DOI

      10.1016/j.pupt.2017.09.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The measurement of cough response to bronchoconstriction induced by methacholine inhalation in healthy subjects: An examination using the Astograph method2017

    • Author(s)
      J Hara, M Fujimura, N Ohkura, T Sakai, K Yamamura, M Abo, H Koba, S Watanabe, T Yoneda, S Nishikawa, T Sone, H Kimura, Y Ishiura, K Kasahara
    • Journal Title

      Exp Lung Res.

      Volume: 7 Issue: 6-7 Pages: 1-9

    • DOI

      10.1080/01902148.2017.1342289

    • NAID

      120006343949

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-El cell functions. Katsuyama M, Demura M, Katsuyama H, Tanii H, Saijoh K2017

    • Author(s)
      Katsuyama M, Demura M, Katsuyama H, Tanii H, Saijoh K.
    • Journal Title

      Molecular Medicine Reports

      Volume: 16 Pages: 873-880

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between posttraumatic stress disorder (PTSD) severity and ego structure of the Nanai people.2017

    • Author(s)
      Ota Y, Korshunova N, Demura M, Katsuyama M, Katsuyama H, Rahayu SR, Saijoh K.
    • Journal Title

      Environ Health Prev Med.

      Volume: 22 Pages: 59-59

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 大気環境中物質とアレルギーの関係2017

    • Author(s)
      東 朋美
    • Journal Title

      アレルギーの臨床

      Volume: 37 Pages: 388-392

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Health effect of Asian dust and air pollutants on allergy.2021

    • Author(s)
      T. Higashi
    • Organizer
      International Joint Symposium, Institute of Nature and Environmental Technology, Kanazawa University To the new stage of collaboration
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 慢性咳嗽の長期予後2021

    • Author(s)
      藤村 政樹 、安井 正英 、武田 玲 、大倉 徳幸 、原 丈介
    • Organizer
      第 23 回日本咳嗽学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 気管支喘息がなく、遷延性・慢性咳嗽の治療によって労作時呼吸困難と労作時低酸素血症が改善した13例2021

    • Author(s)
      藤村政樹、安井正英
    • Organizer
      第87回呼吸器合同北陸地方会
    • Related Report
      2021 Annual Research Report
  • [Presentation] コロナ禍の鼻内視鏡手術におけるエアロゾル低減の試み2021

    • Author(s)
      上野貴雄、古村茂高、平井信行、吉崎智一
    • Organizer
      第83回耳鼻咽喉科臨床学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 粘膜型悪性黒色腫~皮膚原発と比較して~2021

    • Author(s)
      上野貴雄
    • Organizer
      第60回日本鼻科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 製薬関連企業とAcademic Research Organization(ARO)との連携円滑化のための調査2021

    • Author(s)
      山口拓洋, 齋藤明子, 高原志津子, 齋藤俊樹
    • Organizer
      日本臨床試験学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アカデミアにおけるCDISC/SDTM標準導入事例ー金沢大学附属病院の場合ー2021

    • Author(s)
      高原志津子
    • Organizer
      アカデミアにおけるCDISC 利活用ワークショップ
    • Related Report
      2021 Annual Research Report
  • [Presentation] 重症喘息に対する気管支サーモプラスティ(Bronchial thermoplasty:BT)の治療経験2021

    • Author(s)
      原 丈介,笠原寿郎
    • Organizer
      Allergy Seminar in 北陸
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 同意書ID付QRコードを利用したWeb/郵送による問診票データ収集2021

    • Author(s)
      高原志津子、黒川 哲司、今井 康人、村山 敏典
    • Organizer
      日本臨床試験学会 第12回学術集会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] RECISTの施設評価と機械的評価との整合性2021

    • Author(s)
      高原志津子、于佳、澤本由来子、沖谷なほ子、野田まゆみ、青木奈菜代、今井 康人、村山 敏典
    • Organizer
      日本臨床試験学会 第12回学術集会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 知らない人が作ったデータセットを CDISC/SDTM に対応させる手法の検討2021

    • Author(s)
      高原 志津子, 櫻庭 啓一郎, 南 健太, 千葉 吉輝
    • Organizer
      日本臨床試験学会 第12回学術集会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 新型コロナウイルス感染症(COVID-19)に対する臨床研究における研究参加での電子同意取得システムの検証について2021

    • Author(s)
      于佳、野村章洋、米田 隆、今井 康人、村山 敏典
    • Organizer
      日本臨床試験学会 第12回学術集会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Wellness 8次元要素の日本における適応性に関する アンケート調査2021

    • Author(s)
      堀川尚嗣、榊原幹夫、杉本修治、今井康人、金子周一
    • Organizer
      第22回日本健康支援学会年次学術大会・第8回日本介護予防・健康づくり学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] メサコリン誘発咳嗽反応およびカプサイシン咳閾値と,喉頭異常感の関係2020

    • Author(s)
      原 丈介、大倉徳幸、阿保未来、藤村政樹、笠原寿郎
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 気管支熱形成術(BT)を実施した症例における、生物学的製剤の適応の有無とBTの効果(後方視的検討)2020

    • Author(s)
      小川 尚彦, 原 丈介, 山村 健太, 酒井 珠美, 大倉 徳幸, 阿保 未来, 笠原 寿郎
    • Organizer
      第43回日本呼吸器内視鏡学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アトピー咳嗽2020

    • Author(s)
      原 丈介,大倉徳幸,阿保未来,笠原寿郎,藤村政樹
    • Organizer
      第22回日本咳嗽学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] アレルギー性鼻炎治療の実態調査2020

    • Author(s)
      上野貴雄、近藤悟、吉崎智一
    • Organizer
      第38回日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 病態的診断法による慢性咳嗽の診断・治療成績2020

    • Author(s)
      藤村政樹、安井正英、武田玲子、大倉徳幸、原 丈介
    • Organizer
      第22回日本咳嗽学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 慢性咳嗽における小気管支粘液栓(mucoid impaction of small bronchi: MISB)2020

    • Author(s)
      藤村政樹、安井正英、大倉徳幸、原 丈介
    • Organizer
      第22回日本咳嗽学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] コロナ禍の鼻内視鏡手術におけるエアロゾル低減の試み2020

    • Author(s)
      上野貴雄、吉崎智一
    • Organizer
      第59回日本鼻科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] アレルギー性鼻炎治療2020

    • Author(s)
      上野貴雄
    • Organizer
      第2回日本アレルギー学会北陸地方部会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 人工知能を活用した介護業務の効率化2020

    • Author(s)
      村山敏典、今井康人、杉本修治、山崎章子、古川仭、金子周一
    • Organizer
      第27回日本未病学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 病態診断(咳受容体感受性亢進)にて診断したアトピー咳嗽の特徴2019

    • Author(s)
      原 丈介、大倉徳幸、山村健太、阿保未来、野村俊一、赤崎恭太、上田 宰、湯浅瑞希、寺田七朗、佐伯啓吾、松岡寛樹、西川晋吾、丹保裕一、曽根 崇、木村英晴、藤村政樹、笠原寿郎
    • Organizer
      第59回日本呼吸器学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 遷延性・慢性咳芦 性患者の初診時と無症状安定期のメサコリン 誘発咳嗽匹 とカプサイシン咳感受性の推移による病態的確定診断に基づく初診時cut point 値の検討2019

    • Author(s)
      藤村政樹、安井正英、武田玲子、大倉徳幸、原 丈介
    • Organizer
      第94回日本結核病学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 咳喘息の病態診断例における咽喉頭異常感について2019

    • Author(s)
      大倉徳幸、藤村政樹、小川晴彦、山村健太、阿保未来、原 丈介、笠原寿郎
    • Organizer
      第21回日本咳嗽学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] メサコリン誘発咳嗽反応およびカプサイシン咳閾値と、咽喉頭異常感の関係2019

    • Author(s)
      原 丈介、大倉徳幸、阿保未来、笠原寿郎、藤村政樹
    • Organizer
      第21回日本咳嗽学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 咳喘息患者におけるメサコリン誘発咳嗽は咳関連QOLに反映される2019

    • Author(s)
      大倉徳幸,藤村政樹,原丈介,山村健太,阿保未来,曽根 崇,木村英晴,小川晴彦,笠原寿郎
    • Organizer
      第68回日本アレルギー学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 慢性咳嗽の病態的診断への展開2018

    • Author(s)
      藤村政樹、大倉徳幸、原 丈介
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] アレルギー性気管支肺アスペルギルス症に対するMepolizumab2018

    • Author(s)
      原  丈介、大倉徳幸、山村健太、阿保未来、古林崇史、鈴木淳也、佐伯啓吾、木場隼人、内田由佳、丹保裕一、曽根 崇、木村英晴、笠原寿郎
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 繰り返す気道収縮をトリガーとする咳嗽反応に与える影響2018

    • Author(s)
      山村健太、原  丈介、大倉徳幸、藤村政樹、酒井珠美、阿保未来、曽根  崇、木村英晴、笠原寿郎
    • Organizer
      第58回日本呼吸器学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 遷延性・慢性咳嗽患者における喉頭異常感の咳関連QOLに及ぼす影響についての検討2018

    • Author(s)
      大倉徳幸、小川晴彦、山村健太、阿保未来、原  丈介、曽根  崇、木村英晴、笠原寿郎、藤村政樹
    • Organizer
      第67回日本アレルギー学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Bronchial Thermoplasty;Increased Cough Receptor Sensitirity to Capsaicin Predict Positive Therapeutic Response.2018

    • Author(s)
      Yamamura K, Hara J, Ohkura N, Sakai T, Abo M, Kobayashi T, Suzuki J, Saeki K, Koba H, Watanabe S, Uchida Y, Tambo Y, Sone T, Kimura H, Kasahara K
    • Organizer
      ATS2018 International Conference
    • Related Report
      2018 Annual Research Report
  • [Presentation] 慢性咳嗽患者における咽喉頭異常感の咳関連QOL、カプサイシン咳感受性、メサコリン誘発咳嗽に及ぼす影響について2018

    • Author(s)
      大倉徳幸、藤村政樹、山村健太、阿保未来、原  丈介、小川晴彦
    • Organizer
      第20回日本咳嗽学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] アカデミアにおけるCDISC対応の新たな臨床試験データ管理体制モデルの実践を踏まえた課題2018

    • Author(s)
      高原 志津子、吉村健一、今井 康人
    • Organizer
      第9回臨床試験学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 慢性咳嗽患者、気管支喘息患者の咳症状への黄砂とPM2.5の影響2017

    • Author(s)
      東 朋美,原丈介,山村健太,大倉徳幸,阿保未来,上野貴雄,吉崎智一,西條淸史,笠原寿郎
    • Organizer
      第48回 日本職業・環境アレルギー学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 黄砂によるスギ花粉症患者の症状への影響2017

    • Author(s)
      上野貴雄、東朋美、原丈介、笠原寿郎、西條清史、吉崎智一
    • Organizer
      第48回 日本職業・環境アレルギー学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] スエヒロタケによるアレルギー性気管支肺真菌症2017

    • Author(s)
      山村健太,原 丈介,大倉徳幸,小川晴彦,阿保未来,鈴木淳也,古林崇史,佐伯啓吾,木場隼人,内田由佳,丹保裕一,曽根 崇,木村英晴,笠原寿郎
    • Organizer
      第1回 Hokuriku Rising Respiratory Summit
    • Related Report
      2017 Annual Research Report
  • [Presentation] Significance and problems of the CDISC introduction in Academic Research Organization2017

    • Author(s)
      S Takahara
    • Organizer
      CDISC Interchange
    • Related Report
      2017 Annual Research Report
  • [Presentation] miRNA-mediated crosstalk between Wnt3a and TGFP3 in osteoblast differentiation2017

    • Author(s)
      S Fushimi, T Nohno, S Nishimatsu, N Katase, K Terada, M Katsuyama, M Demura, K Saijoh, H Nagatsuka, H Katsuyama.
    • Organizer
      EXPERIMENTAL BIOLOGY
    • Related Report
      2017 Annual Research Report
  • [Book] 専門医のための遷延性・慢性咳嗽の診断と治療に関する指針 2021年度版 NPO法人日本咳嗽学会2021

    • Author(s)
      藤村政樹、新実彰男、内藤建晴、石浦嘉久、松本久子、海老原覚、山田武千代、 小川晴彦、鈴木猛司、原丈介、藤森勝也
    • Total Pages
      50
    • Publisher
      前田書店
    • Related Report
      2021 Annual Research Report

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Published: 2017-04-28   Modified: 2023-01-30  

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