| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
The analysis method for salivary 8-hydroxyguanine (8-OHGua) as an oxidative stress biomarker was established. In the results of epidemiological studies, the salivary 8-OHGua levels were significantly elevated in older persons, as well as those who smoke, have hypertension, or excess visceral fat. By contrast, statistically significant lower levels of 8-OHGua were observed in persons who moderately exercised or recently drank green tea or coffee. The oxidative stress is attracting attention as the cause of a variety of diseases such as cancer. The salivary 8-OHGua is expected to be used for the prevention of lifestyle-related diseases as a promising oxidative stress biomarker. In addition, the usefulness of urinary 8-hydroxydeoxyguanosine as a typical oxidative stress biomarker was reconfirmed in epidemiological study.
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