Evaluation of 8-hydroxyguanine in saliva as an oxidative stress marker
| Project/Area Number |
17H01908
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental risk control and evaluation
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
KAZUAKI KAWAI 産業医科大学, 産業生態科学研究所, 教授 (60161262)
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| Co-Investigator(Kenkyū-buntansha) |
李 云善 産業医科大学, 産業生態科学研究所, 准教授 (90449950)
川崎 祐也 産業医科大学, 産業生態科学研究所, 助教 (30721716)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 8-ヒドロキシグアニン / 8-ヒドロキシデオキシグアノシン / 酸化ストレス / バイオマーカー / 唾液 / 尿 / 生活習慣 / 喫煙 / ８－ヒドロキシグアニン / ８－ヒドロキシデオキシグアノシン / ８－ヒドロキシでオキシグアノシン |
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| Outline of Final Research Achievements |
The analysis method for salivary 8-hydroxyguanine (8-OHGua) as an oxidative stress biomarker was established. In the results of epidemiological studies, the salivary 8-OHGua levels were significantly elevated in older persons, as well as those who smoke, have hypertension, or excess visceral fat. By contrast, statistically significant lower levels of 8-OHGua were observed in persons who moderately exercised or recently drank green tea or coffee. The oxidative stress is attracting attention as the cause of a variety of diseases such as cancer. The salivary 8-OHGua is expected to be used for the prevention of lifestyle-related diseases as a promising oxidative stress biomarker. In addition, the usefulness of urinary 8-hydroxydeoxyguanosine as a typical oxidative stress biomarker was reconfirmed in epidemiological study.
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| Academic Significance and Societal Importance of the Research Achievements |
唾液中の酸化ストレス指標8-ヒドロキシグアニン(8-OHGua)を、高速液体クロマトグラフィーにより精度良く分析する方法を確立した。生体の酸化ストレスは、生活習慣病をはじめとするさまざまな疾病の発症要因の１つとされており、有用な酸化ストレスバイオマーカーを開発する意義は大きい。特に唾液は非侵襲的に採取できることから、人を対象とした疫学研究等に適しており、唾液中8-OHGuaは新たな酸化ストレスバイオマーカーとして期待が持たれる。
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Report
(6 results)
Research Products
(26 results)
