Epigenetic amelioration of overfeeding-inducible functional declines in various organs by medium-chain fatty acids
| Project/Area Number |
17H01964
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三宅 邦夫 山梨大学, 大学院総合研究部, 准教授 (60550712)
三好 規之 静岡県立大学, 食品栄養科学部, 准教授 (70438191)
針谷 夏代 山梨学院大学, 健康栄養学部, 准教授 (80732784)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | BRD4 / 中鎖脂肪酸 / 代謝遺伝子 / 消化吸収遺伝子 / 生活習慣予防 / サルコペニア予防 / ライフステージ / 疾患ステージ / 中鎖脂肪 / 胎生期低栄養 / 成人期 / サルコペニア / エピゲノム / エネルギー代謝 / 骨格筋 / 老齢現象 / トマトパウダー / エピジェネティックス / 代謝 / 低栄養モデル / 過栄養モデル / エピジェネティクス / ヒストンアセチル化 / 過栄養 / 低栄養 |
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| Outline of Final Research Achievements |
In this study, we revealed that medium-chain fatty acids induced expression of insulin-sensitive genes through histone acetylation in adipocytes, induced growth and reduced the risk of lifestyle-related diseases in later life by ameliorating insuficiency of insulin action and by promoting expression of digestive absorption genes. In addition, medium-chain fatty acids inhibited development of life style diseases such as obesity, insulin resistance and their complications in adulthood, and repressed development of malnutrition-related diseases in old age. Our results indicate that medium-chain fatty acids ameliorate organ functions by inducing histone acetylation in cells in particular adipocytes and repress development of life-style diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の学術的意義は、中鎖脂肪酸が、ヒストンアセチル化修飾を介して代謝等の遺伝子の発現を増大させることを明らかにしたことである。社会的意義は、中鎖脂肪酸は、ライフステージ・疾患ステージで臓器機能の低下を回復し、多くの疾患を改善しうる点を示したことである。
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] o-ingestion of barley and grated yam paste with rice reduces postprandial glucose and insulin response in healthy Japanese participants: a randomized cross-over trial. o-ingestion of barley and grated yam paste with rice reduces postprandial glucose and insulin response in healthy Japanese participants: a randomized cross-over trial.2020
Author(s)
Matsuoka T, Tsuchida A, Yamaji A, Kurosawa C, Shinohara M, Takayama I, Nakagomi H, Izumi K, Ichikawa Y, Hariya N, Yamashita S, Mochizuki K.
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Journal Title
Nutrition
Volume: 72
Pages: 110637-110637
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Plasticity of histone modifications around Cidea and Cidec genes with secondary bile in the amelioration of developmentally-programmed hepatic steatosis2019
Author(s)
Urmi JF, Itoh H, Muramatsu-Kato K, Kohmura-Kobayashi Y, Hariya N, Jain D, Tamura N, Uchida T, Suzuki K, Ogawa Y, Shiraki N, Mochizuki K, Kubota T, Kanayama N.
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Journal Title
Sci Rep.
Volume: 19;9(1)
Pages: 17100-17100
NAID
Related Report
Peer Reviewed / Open Access
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