| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
We found that increasing or decreasing SIRT1 expression levels specifically in the brain altered nutrient preferences. Brain SIRT1 promoted fat preference whereas it suppressed sugar preference. We found that simple sugar preference is regulated by a negative feedback mechanism mediated by the FGF21-oxytocin system. Simple sugar ingestion induces the release of hepatokine FGF21, which activates oxytocin neuron in the hypothalamus. It leads to the release of oxytocin within the central nervous system, and the binding of oxytocin to its receptor suppressed simple sugar preference. We also found that SIRT1 promoted the expression of the FGF21 receptor, thereby improved FGF21 sensitivity and potentiated the negative feedback regulation of the simple sugar preference mediated by the FGF21-oxytocin system.
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