| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
We performed an in vitro evaluation on adhesion behavior of proteins at the inner surface of fully covered self-expandable metallic stents coated with biocompatible polymers. Model bile solution, fibrinogen, and albumin were used to reveal the inhibitory ability of the polymer coatings. The amount of adsorbed proteins and adhered bacteria (E. coli) on the polymer coatings were both strongly inhibited. Circulation test with bile was additionally performed under a clinical condition; adsorption/deformation of proteins and early-stage sludge formation were inhibited on the stent’s surface coated with polyacrylate derivatives. The present study has revealed that the polymer coated stents suppressed the early-stage biliary sludge formation and the sludge formation inhibition must have been attained by the strong resistance of the polymers to protein adsorption/deformation. This material-based method differs from traditional bile sludge control that relies on the use of antibiotics.
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