| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2017: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Molecular diffusion into living cells was proposed as a new mechanism of amphiphilic polymer permeation through cell membrane. By attaching functional groups to the polymer, enhancement of cell-specific functions was realized. An electron transport polymer (pMFc) was synthesized from MPC and vinyl ferrocene (VFc). Metabolic alterations were verified for glucose anaerobic glycolysis metabolism in yeast. Anaerobic cultivation of yeast in the presence of oxidized pMFc showed a good correlation between the change in ethanol fermentation and the electron transport rate. It was shown that the degree of metabolic modification of yeast can be controlled by pMFc. Otherwise, using human breast cancer cells, it has found that the electron transport polymer was significantly useful as a cancer cell-selective growth inhibition.
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