Targeted oligonucleotide delivery by unit polyion complexes
| Project/Area Number |
17H02098
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Miyata Kanjiro 東京大学, 大学院工学系研究科(工学部), 准教授 (50436523)
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| Project Period (FY) |
2017-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | 生体材料 / ドラッグデリバリー / 核酸医薬 / がん治療 / 核酸医薬デリバリー / ポリイオンコンプレックス / ブロック共重合体 / 高分子材料 / 薬物送達システム |
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| Outline of Final Research Achievements |
In this study, we developed a ultra-small nanocarrier, termed uint polyion complex (uPIC), for cancer-targeted oligonucleotide delivery. Fine-tuning of the length and shape of block copolymers allowed for the formation of ~18 nm-sized uPICs in aqueous media. The uPICs efficiently accumulated in murine models of pancreatic cancer and brain tumor, leading to the significantly enhanced antitumor efficacy.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、高分子材料の精密設計を通じて、1分子の核酸医薬を選択的に搭載したポリイオンコンプレックス(PIC)の構築に成功しており、高分子集合体の観点で非常に興味深い知見を得ている。さらに、そのPICのサイズが約18 nmと非常に小さいことに着目し、既存のナノ医薬(約100 nm)では送達困難とされる難治がん組織(膵臓がんや脳腫瘍モデル)に対しても効果的に核酸医薬を送達することに成功した。結果として、安全かつ優れた抗腫瘍効果を得ることに成功しており、新規がん治療法の創出に貢献するものと期待される。
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo.2019
Author(s)
Takai T、 Tsujino T, Yoshikawa Y, Inamoto T, Sugito N, Kuranaga Y, Heishima K, Soga T, Hayashi K, Miyata K, Kataoka K, Azuma H, Akao Y.
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Journal Title
Mol Ther.
Volume: S1525-0016（１９）
Issue: 5
Pages: 30090-5
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Anti-cancer effects of a chemically modified miR-143 on bladder cancer by either systemic or intravesical treatment2019
Author(s)
Y. Yoshikawa, K. Taniguchi, T. Tsujino, K. Heishima, T. Inamoto, T. Takai, K. Minami, H. Azuma, K. Miyata, K. Hayashi, K. Kataoka, Y. Akao
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Journal Title
Molecular Therapy: Methods and Clinical Development
Volume: 13
Pages: 290-302
DOI
Related Report
Peer Reviewed
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[Journal Article] Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells.2019
Author(s)
Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka
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Journal Title
J. Control. Release
Volume: 295
Pages: 268-277
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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