Development of transvenous liver-specific mesenchymal stem cell transplantation therapy by cell-modification

• Project/Area Number: 17H02100
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Osaka University
• Principal Investigator: Yamashita Shizuya 大阪大学, 産業科学研究所, 招へい教授 (60243242)
• Co-Investigator(Kenkyū-buntansha): 小関 正博 大阪大学, 医学系研究科, 助教 (10467582) ; 黒田 俊一 大阪大学, 産業科学研究所, 教授 (60263406)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 幹細胞移植 / 家族性高コレステロール血症 / 細胞治療 / 糖鎖修飾 / 肝特異的 / 間葉系幹細胞 / 再生医療 / 肝臓特異的 / 頸静脈 / 間葉系幹細胞移植 / 経静脈的 / 脂肪組織由来間葉系幹細胞

Outline of Final Research Achievements

Aiming at the development of mesenchymal stem cell transplantation therapy for patients with homozygous familial hypercholesterolemia (FH), we have developed a technology to modify stem cell surface with glycosylated-fatty acid, which has a specific receptor in the liver, to enable liver-specific cell transplantation even after transvenous cell transplantation. Although the cells were modified with glycolipid derivatives of fatty acids bound to sugar chain X, labeled with fluorescent dyes, and studied by tail vein injection into nude mice for in vivo imaging, it has been difficult to solve the issue of cytotoxicity.
On the other hand, we created a genetic diagnosis panel for dyslipidemia in more than 100 patients with FH and performed genetic analysis, and obtained findings such as the presence of double gene mutations that may be useful for transplantation.

Academic Significance and Societal Importance of the Research Achievements

幹細胞自体に修飾を行うことによって、臓器特異的に移植細胞を送達しようとする試みは独創的であった。しかしながら細胞修飾による細胞毒性の克服には課題があった。
家族性高コレステロール血症患者に対しては、世界的には完全ヒト化モノクローナル抗体医薬の開発が進んでいるが、あくまで根治的な治療は肝臓におけるLDL受容体活性を回復することである。被験者になりうる患者の遺伝子変異情報を得られたことは、最終的な細胞移植療法の実現につながると考えられる。

Research Products

• [Journal Article] Pemafibrate, a New Selective PPARα Modulator: Drug Concept and Its Clinical Applications for Dyslipidemia and Metabolic Diseases. (2020)
  • Author(s): Yamashita S, Masuda D, Matsuzawa Y
  • Journal Title: Curr Atheroscler Rep Volume: 22 Issue: 1 Pages: 5-5
  • DOI: 10.1007/s11883-020-0823-5
  • Peer Reviewed / Open Access
• [Journal Article] Omega-3 fatty acid ethyl esters improve low-density lipoprotein subclasses without increasing low-density lipoprotein-cholesterol levels: A phase 4, randomized study. (2020)
  • Author(s): Masuda D, Miyata Y, Matsui S, Yamashita S
  • Journal Title: .Atherosclerosis. Volume: 292 Pages: 163-170
  • DOI: 10.1016/j.atherosclerosis.2019.11.014
  • Peer Reviewed / Open Access
• [Journal Article] Progranulin deficiency leads to enhanced age-related cardiac hypertrophy through complement C1q-induced β-catenin activation. (2020)
  • Author(s): Zhu Y, Ohama T, Kawase R, Chang J, Inui H, Kanno K, Okada T, Masuda D, Koseki M, Nishida M, Sakata Y, Yamashita S.
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 138 Pages: 197-211
  • DOI: 10.1016/j.yjmcc.2019.12.009
  • Peer Reviewed / Open Access
• [Journal Article] Rivaroxaban Suppresses the Progression of Ischemic Cardiomyopathy in a Murine Model of Diet-Induced Myocardial Infarction (2019)
  • Author(s): Liu J, Nishida M, Inui H, Chang J, Zhu Y, Kanno K, Matsuda H, Sairyo M, Okada T, Nakaoka H, Ohama T, Masuda D, Koseki M, Yamashita S, Sakata Y.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 10 Pages: 915-930
  • DOI: 10.5551/jat.48405
  • NAID: 130007722198
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-10-01
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Applications of a Novel Selective PPARα Modulator, Pemafibrate, in Dyslipidemia and Metabolic Diseases (2019)
  • Author(s): Yamashita S, Masuda D, Matsuzawa Y.Yamashita S, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 5 Pages: 389-402
  • DOI: 10.5551/jat.48918
  • NAID: 130007641200
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-05-01
  • Peer Reviewed / Open Access
• [Journal Article] Real-World Data to Identify Hypercholesterolemia Patients on Suboptimal Statin Therapy (2019)
  • Author(s): Kajinami K, Ozaki A, Tajima Y, Yamashita S, Arai H, Teramoto T.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 5 Pages: 408-431
  • DOI: 10.5551/jat.46201
  • NAID: 130007641196
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-05-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-Term Treatment With Evolocumab Among Japanese Patients ― Final Report of the OSLER Open-Label Extension Studies ― (2019)
  • Author(s): Hirayama A, Yamashita S, Ruzza A, Inomata H, Cyrille M, Lu C, Hamer AW, Yoshida M, Kiyosue A, Teramoto T.Hirayama A, et al.
  • Journal Title: Circulation Journal Volume: 83 Issue: 5 Pages: 971-977
  • DOI: 10.1253/circj.CJ-19-0139
  • NAID: 130007636984
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-04-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cultural Barriers in the Treatment of Dyslipidemia: A Survey of Japanese Physician Attitudes (2019)
  • Author(s): Yamashita Shizuya、Masuda Daisaku、Arai Hidenori、Matsuzawa Yuji
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 2 Pages: 154-169
  • DOI: 10.5551/jat.44677
  • NAID: 130007590198
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-02-01
  • Peer Reviewed / Open Access
• [Journal Article] Residual vascular risk in diabetes ? Will the SPPARM alpha concept hold the key? (2019)
  • Author(s): Fruchart Jean-Charles、Santos Raul D.、Yamashita Shizuya、Libby Peter、Fruchart Jean-Charles、Santos Raul D.、Yamashita Shizuya、Aikawa Masanori、Libby Peter、Plutzky Jorge、Pradhan Aruna、Ridker Paul、Aguilar-Salinas Carlos、Al Rasadi Khalid、Yokote Koutaro、Zambon Alberto
  • Journal Title: Diabetes & Metabolic Syndrome: Clinical Research & Reviews Volume: 13 Issue: 4 Pages: 2723-2725
  • DOI: 10.1016/j.dsx.2019.05.034
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Long-Term Efficacy and Safety of Pemafibrate, a Novel SelectivePeroxisome Proliferator-Activated Receptor-α Modulator (SPPARMα),in Dyslipidemic Patients with Renal Impairment (2019)
  • Author(s): Yokote K, Yamashita S, Arai H, Araki E, Suganami H, Ishibashi S, Of TheK-Study Group OB
  • Journal Title: Int J Mol Sci Volume: 20(3) Issue: 3 Pages: 706-706
  • DOI: 10.3390/ijms20030706
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of pemafibrate in people with type 2 diabetes and elevated triglyceride levels: 52‐week data from the PROVIDE study (2019)
  • Author(s): Araki Eiichi、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Satoh Jo、Inoguchi Toyoshi、Nakamura Jiro、Maegawa Hiroshi、Yoshioka Narihito、Tanizawa Yukio、Watada Hirotaka、Suganami Hideki、Ishibashi Shun
  • Journal Title: Diabetes, Obesity and Metabolism Volume: 21 Issue: 7 Pages: 1737-1744
  • DOI: 10.1111/dom.13686
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Pemafibrate, a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator (SPPARMα): Pooled Analysis of Phase 2 and 3 Studies in Dyslipidemic Patients with or without Statin Combination (2019)
  • Author(s): Yamashita、Arai、Yokote、Araki、Matsushita、Nojima、Suganami、Ishibashi
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 22 Pages: 5537-5537
  • DOI: 10.3390/ijms20225537
  • Peer Reviewed / Open Access
• [Journal Article] Comparative aspects of the care of familial hypercholesterolemia in the "Ten Countries Study". (2019)
  • Author(s): Pang J, Chan DC, Hu M, Muir LA, Kwok S, Charng MJ, Florkowski CM, George PM, Lin J, Loi DD, Marais AD, Nawawi HM, Gonzalez-Santos LE, Su TC, Truong TH, Santos RD, Soran H, Tomlinson B, Yamashita S, Ademi Z, Watts GF.
  • Journal Title: J Clin Lipidol. Volume: 13 Issue: 2 Pages: 287-300
  • DOI: 10.1016/j.jacl.2019.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Shotgun proteomic analysis reveals proteome alterations in HDL of patients with cholesteryl ester transfer protein deficiency. (2019)
  • Author(s): Okada T, Ohama T, Takafuji K, Kanno K, Matsuda H, Sairyo M, Zhu Y, Saga A, Kobayashi T, Masuda D, Koseki M, Nishida M, Sakata Y, Yamashita S.
  • Journal Title: J Clin Lipidol Volume: 印刷中 Issue: 2 Pages: 317-325
  • DOI: 10.1016/j.jacl.2019.01.002
  • Peer Reviewed / Open Access
• [Journal Article] Accelerated Atherogenicity in Tangier Disease (2018)
  • Author(s): Muratsu Jun、Koseki Masahiro、Masuda Daisaku、Yasuga Yuji、Tomoyama Satoki、Ataka Keiji、Yagi Yoshiki、Nakagawa Atsushi、Hamada Hidehumi、Fujita Shigeki、Hattori Hiroaki、Ohama Tohru、Nishida Makoto、Hiraoka Hisatoyo、Matsuzawa Yuji、Yamashita Shizuya
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 10 Pages: 1076-1085
  • DOI: 10.5551/jat.43257
  • NAID: 130007490917
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-10-01
  • Peer Reviewed / Open Access
• [Journal Article] Treatment Patterns and Lipid Profile in Patients with Familial Hypercholesterolemia in Japan (2018)
  • Author(s): Teramoto Tamio、Kai Takahito、Ozaki Asuka、Crawford Bruce、Arai Hidenori、Yamashita Shizuya
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 7 Pages: 580-592
  • DOI: 10.5551/jat.41483
  • NAID: 130007386957
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Effects of a Dipeptidyl Peptidase 4 Inhibitor Sitagliptin on Glycemic Control and Lipoprotein Metabolism in Patients with Type 2 Diabetes Mellitus (GLORIA Trial) (2018)
  • Author(s): Masuda Daisaku、Kobayashi Takuya、Sairyou Masami、Hanada Hiroyuki、Ohama Tohru、Koseki Masahiro、Nishida Makoto、Maeda Norikazu、Kihara Shinji、Minami Tatsuya、Yanagi Koji、Sakata Yasushi、Yamashita Shizuya
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 6 Pages: 512-520
  • DOI: 10.5551/jat.41343
  • NAID: 130007382552
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Guidance for Pediatric Familial Hypercholesterolemia 2017 (2018)
  • Author(s): Harada-Shiba Mariko、Ohta Takao、Ohtake Akira、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Yamashita Shizuya、Yokote Koutaro、Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 6 Pages: 539-553
  • DOI: 10.5551/jat.CR002
  • NAID: 130007382567
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2018-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Particle number analysis of lipoprotein subclasses by gel permeation HPLC in patients with cholesteryl ester transfer protein deficiency (2018)
  • Author(s): Okada Takeshi、Ohama Tohru、Okazaki Mitsuyo、Kanno Kotaro、Matsuda Hibiki、Sairyo Masami、Zhu Yinghong、Saga Ayami、Kobayashi Takuya、Masuda Daisaku、Koseki Masahiro、Nishida Makoto、Sakata Yasushi、Yamashita Shizuya
  • Journal Title: PLOS ONE Volume: 13 Issue: 1 Pages: 0190875-0190875
  • DOI: 10.1371/journal.pone.0190875
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features and visual function in a patient with Fish-eye disease: Quantitative measurements and optical coherence tomography (2018)
  • Author(s): Kanai Masanori、Koh Shizuka、Masuda Daisaku、Koseki Masahiro、Nishida Kohji
  • Journal Title: American Journal of Ophthalmology Case Reports Volume: 10 Pages: 137-141
  • DOI: 10.1016/j.ajoc.2018.02.016
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Genetic Testing for Familial Hypercholesterolemia: JACC Scientific Expert Panel (2018)
  • Author(s): Amy C.Sturm MS,Joshua W.Knowles, Samuel S.Gidding, Zahid S.Ahmad, S Yamashita, Daniel J.Rader, et al
  • Journal Title: J Am Coll Cardiol. Volume: 72 Pages: 662-680
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cholesteryl ester transfer protein: An enigmatic pharmacology - Antagonists and agonists. (2018)
  • Author(s): ShizuyaYamashita, Massimiliano Ruscica, Chiara Macchi, Alberto Corsini, Yuji Matsuzawa, Cesare R. Sirtori
  • Journal Title: Atherosclerosis. Volume: 278 Pages: 286-298
  • Peer Reviewed / Open Access
• [Journal Article] Statement for Appropriate Clinical Use of PCSK9 Inhibitors (2018)
  • Author(s): Atsushi Nohara, Hirotoshi Ohmura, Hiroaki Okazaki, Masatsune Ogura, Kazuo Kitagawa, Masahiro Koseki, Kayoko Sato, Kazuhisa Tsukamoto, Shizuya Yamashita
  • Journal Title: J Atheroscler Thromb. Volume: 25 Pages: 747-750
  • NAID: 130007429079
  • Peer Reviewed / Open Access
• [Journal Article] An implication of Klotho-related molecules in different smoking-related health outcomes between men and women (2018)
  • Author(s): Nakanishi Kaori、Nishida Makoto、Yamamoto Ryohei、Koseki Masahiro、Moriyama Toshiki、Yamauchi-Takihara Keiko
  • Journal Title: Clin Chim Acta Volume: 476 Pages: 44-48
  • DOI: 10.1016/j.cca.2017.11.007
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results from a 24-week, randomized, double blind, active-controlled, phase 3 trial (2018)
  • Author(s): Shun Ishibashi, Hidenori Arai, Koutaro Yokote, Eiichi Araki, Hideki Suganami, Shizuya Yamashita
  • Journal Title: J Clin Lipidol. Volume: 12 Issue: 1 Pages: 173-184
  • DOI: 10.1016/j.jacl.2017.10.006
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Selective PPARα Modulator (SPPARMα), K-877 (Pemafibrate), Attenuates Postprandial Hypertriglyceridemia in Mice (2018)
  • Author(s): Masami Sairyo, Takuya Kobayashi, Daisaku Masuda, Koutaro Kanno, Yinghong Zhu, Takeshi Okada, Masahiro Koseki, Tohru Ohama, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 25 Issue: 2 Pages: 142-152
  • DOI: 10.5551/jat.39693
  • NAID: 130006328538
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of effects of anagliptin and alogliptin on serum lipid profile in type 2 diabetes mellitus patients (2018)
  • Author(s): Akira Kurozumi, Yosuke Okada, Tadashi Arao, Takuya Kobayashi, Daisaku Masuda, Shizuya Yamashita, Yoshiya Tanaka
  • Journal Title: J Diabetes Investig. Volume: 9 Issue: 2 Pages: 360-365
  • DOI: 10.1111/jdi.12739
  • Peer Reviewed
• [Journal Article] Effects of Pemafibrate, a Novel Selective PPARα Modulator, on Lipid and Glucose Metabolism in Patients With Type 2 Diabetes and Hypertriglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial (2018)
  • Author(s): Araki Eiichi、Yamashita Shizuya、Arai Hidenori、Yokote Koutaro、Satoh Jo、Inoguchi Toyoshi、Nakamura Jiro、Maegawa Hiroshi、Yoshioka Narihito、Tanizawa Yukio、Watada Hirotaka、Suganami Hideki、Ishibashi Shun
  • Journal Title: Diabetes Care Volume: 41 Issue: 3 Pages: 538-546
  • DOI: 10.2337/dc17-1589
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Long-term Coadministration of Fenofibrate and Ezetimibe in Patients with Combined Hyperlipidemia: Results of the EFECTL Study (2017)
  • Author(s): Oikawa Shinichi、Yamashita Shizuya、Nakaya Noriaki、Sasaki Jun、Kono Suminori、for the Effect of Fenofibrate and Ezetimibe Combination Treatment on Lipid (EFECTL) Study Investigators
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 1 Pages: 77-94
  • DOI: 10.5551/jat.35626
  • NAID: 130005188281
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed
• [Journal Article] Enhanced Intestinal Absorption of Cholesterol along with Increased Chylomicron Remnants for De novo Progression of Coronary Stenosis (2017)
  • Author(s): Shinichi Oikawa, Shizuya Yamashita, Noriaki Nakaya, Jun Sasaki, Suminori Kono, for the Effect of Fenofibrate and Ezetimibe Combination Treatment on Lipid (EFECTL) Study Investigators
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 2 Pages: 120-122
  • DOI: 10.5551/jat.ED065
  • NAID: 130005306537
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Postprandial Hyperlipidemia and Remnant Lipoproteins (2017)
  • Author(s): Daisaku Masuda, Shizuya Yamashita
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 2 Pages: 95-109
  • DOI: 10.5551/jat.RV16003
  • NAID: 130005306535
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Homogeneous Assays for LDL-C and HDL-C are Reliable in Both the Postprandial and Fasting State (2017)
  • Author(s): Takashi Miida, Kunihiro Nishimura, Satoshi Hirayama, Yoshihiro Miyamoto, Masakazu Nakamura, Daisaku Masuda, Shizuya Yamashita, Shoji Ushiyama, Naohisa Fujita, Shinji Yokoyama, Tamio Teramoto
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 24 Issue: 6 Pages: 583-599
  • DOI: 10.5551/jat.40006
  • NAID: 130005687828
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] One-Year Efficacy and Safety of Evolocumab in Japanese Patients ― A Pooled Analysis From the Open-Label Extension OSLER Studies ― (2017)
  • Author(s): Atsushi Hirayama, Shizuya Yamashita, Hyoe Inomata, Helina Kassahun, Marcoli Cyrille, Andrea Ruzza, Masayuki Yoshida, Arihiro Kiyosue, Yuhui Ma, Tamio Teramoto
  • Journal Title: Circulation Journal Volume: 81 Issue: 7 Pages: 1029-1035
  • DOI: 10.1253/circj.CJ-16-1016
  • NAID: 130006887053
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), in combination with statin treatment: Two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia (2017)
  • Author(s): Hidenori Arai, Shizuya Yamashita, Koutaro Yokote, Eiichi Araki, Hideki Suganami, Shun Ishibashi
  • Journal Title: Atherosclerosis. Volume: 261 Pages: 144-152
  • DOI: 10.1016/j.atherosclerosis.2017.03.032
  • Peer Reviewed / Open Access
• [Journal Article] Widespread Coronary Dysfunction in the Absence of HDL Receptor SR-B1 in an Ischemic Cardiomyopathy Mouse Model. (2017)
  • Author(s): Pearson JT, Yoshimoto M, Chen YC, Sultani R, Edgley AJ, Nakaoka H, Nishida M, Umetani K, Waddingham MT, Jin HL, Zhang Y, Kelly DJ, Schwenke DO, Inagaki T, Tsuchimochi H, Komuro I, Yamashita S, Shirai M.
  • Journal Title: Sci Rep Volume: Dec 22;7(1) Issue: 1 Pages: 18108-18108
  • DOI: 10.1038/s41598-017-18485-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] A selective PPARα modulator, pemafibrate reduced hepatic cholesterol content and inflammatory cell infiltration in atherogenic-diet induced steatohepatitis mouse model (2020)
  • Author(s): Kanno K, Koseki M, Saga A, Chang J, Okada T, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
  • Organizer: Keystone Symposia 2020
  • Int'l Joint Research
• [Presentation] The Current Status of the Treatment of FH Patients and the Achievement of LDL-C Target Value in the Lipid Clinic in Osaka University Hospital (2019)
  • Author(s): Koseki M, Okada T, Kanno K, Ohama T, Nishida M, Yamashita S, Sakata Y.
  • Organizer: FH Global Summit
  • Int'l Joint Research
• [Presentation] Pemafibrate regulate intestinal lipid absorption in diet-induced nonalcoholic steatohepatitis model in mice (2019)
  • Author(s): 冠野 昂太郎、小関 正博、嵯峨 礼美、常 久洋、岡田 健志、乾 洋勉、朝治 真澄、朱 穎竑、大濱 透、西田 誠、山下 静也、坂田 泰史
  • Organizer: AHA2019
  • Int'l Joint Research
• [Presentation] The Predominance of Th1 and Th17 During the Process of Myocardial Infarction in Non-surgical MI model, SR-BI KO/ApoeR61h/h mice (2019)
  • Author(s): Inui H, Nishida M, Asaji M, Saga A, Kanno K , Chang J, Zhu Y , Okada T, Ohama T , Koseki M, Yamashita S, Sakata Y.
  • Organizer: AHA2019
  • Int'l Joint Research
• [Presentation] Pgrn Suppresses Pressure Overload-induced Cardiac Hypertrophy And Heart Failure In Mice Via Inhibiting The Activation Of β-catenin (2019)
  • Author(s): Zhu Y, Ohama T, Inui H, Kanno K, Chang J, Okada T, Koseki M, Nishida M, Sakata Y, Yamashita S.
  • Organizer: AHA2019
  • Int'l Joint Research
• [Presentation] Managemet of Hypertriglyceridemia as a Residual Risk:Potentoal Role of a Novel Selective PPAR α Modulator(SPPARMα） (2018)
  • Author(s): Shizuya Yamashita
  • Organizer: APSC(ASIAN PACIFIC SOCIETY OF CARDIOLIGY CONGRESS)2018
  • Int'l Joint Research / Invited
• [Presentation] Lipoprotein Particle Number Analysis of Detailed Subclasses by Gel Permeation HPLC (2018)
  • Author(s): Takeshi Okada, Tohru Ohama, Hiroyasu Inui, Kotaro Kanno, Hibiki Matsuda, Yinghong Zhu, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata,
  • Organizer: Gordon Research Conference 2018 Lipoprotein Metabolism
  • Int'l Joint Research
• [Presentation] Atherogenicity in Tangier Disease - Literature-based Analysis and A Case Report- (2018)
  • Author(s): Masahiro Koseki, Shizuya Yamashita,Yasushi Sakata
  • Organizer: Gordon Research Conference 2018 Lipoprotein Metabolism
  • Int'l Joint Research
• [Presentation] 1. Enforced retrograde transportation contributes lesion C-reactive protein to circulation 2.Roles of The bHLH Transcription Factor Tcf21 in Cardiorenal Syndrome (2018)
  • Author(s): Shizuya Yamashita
  • Organizer: China-Japan International Conference on Atherosclerosis 2018
  • Int'l Joint Research / Invited
• [Presentation] Effect of a SPPARMα on macrophage cholesterol efflux to HDL (2018)
  • Author(s): Shizuya Yamashita
  • Organizer: The Selective Peroxisome Proliferator-Activated Receptor Alpha Modulator (SPPARMα) Concept NEW HORIZONS FOR RESIDUAL VASCULAR RISK?
  • Int'l Joint Research / Invited
• [Presentation] Rivaroxaban Improves the Progression of Ischemic Cardiomyopathy in a New Murine Model of Diet-Induced Myocardial Infarction (2018)
  • Author(s): Jingyi Liu,Makoto Nishida,、Hiroyasu Inui, Kotaro Kanno,Hibiki Matsuda,Takeshi Okada,Masami Sairyo,Daisaku Masuda,Toru Ohhama,Masahiro Koseki,Yasushi Sakata,Shizuya Yamashita
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] 「FH awareness～いま、FH を再考する～」Atherogenicity through Known and Unknown Mechanisms in FH (2018)
  • Author(s): 小関正博
  • Organizer: 第82回日本循環器学会学術集会
  • Invited
• [Presentation] TTC39B Inhibition Attenuate Ubiquitination andProteasomal Degradation of LXR and Improve BothAtherosclerosis and Non-Alcoholic Steatohepatitis (2018)
  • Author(s): Masahiro Koseki, Shizuya Yamashita,Yasushi Sakata
  • Organizer: 第82回日本循環器学会学術集会
• [Presentation] Promotion of FH Awareness in Japan:Messages from Japan Atherosclerosis Society(JAS) (2018)
  • Author(s): 山下静也
  • Organizer: 第82回日本循環器学会学術集会
  • Invited
• [Presentation] Management of atherogenic dyslipidaemia associated with visceral obesity: Potential role of a novel selective peroxisome proliferator-activated receptor αmodulator(SPPARMα） (2017)
  • Author(s): Yamashita Shizuya
  • Organizer: 85th EAS CONGRESS
  • Int'l Joint Research
• [Presentation] Shotgum Proteomics Analysis Characterizes HDL Proteome in Patients with Cholesteryl Eater Transfer Protein Deficiency (2017)
  • Author(s): Okada T, Ohama T, Kanno K, Matsuda H, Sairyo M, Zhu Y, Saga A, Kobayashi T, Masuda D, Koseki M, Nishida M, Sakata Y, Yamashita S
  • Organizer: 85th EAS CONGRESS
  • Int'l Joint Research
• [Presentation] Analysis of Selectively Isolated Chylomicron Remnants in Various conditions (2017)
  • Author(s): Masuda D, Kobayashi T, Sairyo M, Okada T, Koseki M, Ohama T, Nishida M, Sakata Y, Yamashita S
  • Organizer: 85th EAS CONGRESS
  • Int'l Joint Research
• [Presentation] Mechanism of Short term Fructose Expose Exposure Induced chylomicron Secretion (2017)
  • Author(s): Kobayashi T, Masuda D, Sairyo M, Okada T, Koseki M, Ohama T, Nishida M, Sakata Y, Yamashita S
  • Organizer: 85th EAS CONGRESS
  • Int'l Joint Research
• [Presentation] THE ROLE OF TTC39B IN ATHEROSCLEROSIS AND NON-ALCOHOLIC STEATOHEPATITIS (2017)
  • Author(s): Masahiro Koseki, Joanne Hsieh, Matthew Molusky, Emi Yakushiji, Marit Westerterp, Ikuyo Ichi, Sandra Abramowicz, Liana Tascau, Carrie Welch, Shunichi Takiguchi, Jahangir Iqbal, Yasushi Sakata, Shizuya Yamashita, M. Mahmood Hussain, Daniel J. Rader and Alan R. Tall
  • Organizer: 85th EAS CONGRESS
  • Int'l Joint Research
• [Presentation] ICoLA2017 (2017)
  • Author(s): Yamashita Shizuya
  • Organizer: Guidelines for Preventing Cardiovascular Diseases in Japan
  • Int'l Joint Research / Invited
• [Presentation] LXR,atherosclerosis,and steatohepatitis (2017)
  • Author(s): Masahiro Koseki
  • Organizer: The61 Annual Scientific Meeting of Korean Society of Cardiology(KSC2017）
  • Int'l Joint Research / Invited
• [Presentation] Development of Enzyme-Linked Immunosorbent Assay for Oxidized High Density Lipoprotein and Its Clinical Application for Cardiovascular Risk Assessment (2017)
  • Author(s): Takeshi Okada, Tohru Ohama, Mizuki Sumida, Yuki Katayama, Kotaro Kanno, Hibiki Matsuda, Masami Sairyo, Yinghong Zhu, Ayami Saga, Takuya Kobayashi, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Norihiko Kayahara, Yasushi Sakata, Shizuya Yamashita
  • Organizer: 85th EAS CONGRESS
• [Presentation] 動脈硬化性疾患予防 ガイドライン2017 (2017)
  • Author(s): 山下静也
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] HDLと動脈硬化 (2017)
  • Author(s): 山下静也
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] 原発性高脂血症診療の新展開 Tangier病 (2017)
  • Author(s): 小関正博
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] 「家族性高コレステロール血症に対する再生医療・細胞治療の臨床応用」 (2017)
  • Author(s): 小関正博
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] Achilles Tendon Thickness among the Patients with Acute Coronary Syndrome Enrolled in EXPLORE-J (2017)
  • Author(s): Atsushi Nohara, Hidenori Arai, Mariko Harada-Shiba, Shizuya Yamashita, Tohru Yoshizumi, Junya Ako, Atsushi Hirayama, Asuka Ozaki, Kiyoko Uno, Masato Nakamura
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] Shotgun Proteomic Analysis of HDL in Patients with Cholesteryl Ester Transfer Protein Deficiency (2017)
  • Author(s): Takeshi Okada, Tohru Ohama, Kotaro Kanno, Hibiki Matsuda, Masami Sairyo, Yinghong Zhu, Ayami Saga, Takuya Kobayashi, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] Mechanism of short term fructose exposure induced chylomicron secretion (2017)
  • Author(s): Takuya Kobayashi, Masami Sairyo, Daisaku Masuda, Kotaro Kanno, Hibiki Matsuda, Takeshi Okada, Tohru Ohama, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] Anagliptin Attenuates Fasting and Postprandial Hypertriglyceridemia due to The Lowering m-RNA Expressions of Proteins Related to Lipoprotein Metabolism (2017)
  • Author(s): Masami Sairyo, Daisaku Masuda, Takuya Kobayashi, Kotaro Kanno, Hibiki Matsuda, Takeshi Okada, Masahiro Koseki, Tohru Ohama, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] Enhanced Age-Related Cardiac Hypertrophy in Progranulin-deficient Mice (2017)
  • Author(s): Yinghong Zhu, Tohru Ohama, Kotaro Kanno, Hibiki Matsuda, Masami Sairyo, Takeshi Okada, Daisaku Masuda, Masahiro Koseki, Makoto Nishida, Yasushi Sakata, Shizuya Yamashita
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] 家族性高コレステロール血症に対する再生医療・細胞治療の臨床応用 (2017)
  • Author(s): 小関 正博, 嵯峨 礼美, 岡田 健志, 冠野昂太郎, 冨田 興一, 大須賀慶吾, 江副 幸子, 西田 誠, 坂田 泰史, 山下 静也
  • Organizer: 第49回日本動脈硬化学会総会・学術集会
• [Presentation] 「脂質異常症治療薬の新展開」 高コレステロール血症治療薬の新時代 (2017)
  • Author(s): 小関正博
  • Organizer: 第65回日本心臓病学会
  • Invited
• [Presentation] メタボリックシンドロームと動脈硬化症～脂質異常症の観点から～ (2017)
  • Author(s): 山下静也
  • Organizer: 第38回日本肥満学会
  • Invited
• [Presentation] 脂質異常症治療の新しい潮流 (2017)
  • Author(s): 山下静也
  • Organizer: 第31回日本臨床内科医学会
  • Invited
• [Presentation] 高血圧性脳合併症の最新治療 (2017)
  • Author(s): 山下静也
  • Organizer: 第40回日本高血圧学会
  • Invited
• [Presentation] 動脈硬化性疾患予防ガイドライン2017を踏まえて (2017)
  • Author(s): 小関正博
  • Organizer: FH疾患啓発研修会
  • Invited
• [Presentation] FHの薬物治療 (2017)
  • Author(s): 小関正博
  • Organizer: FH疾患啓発研修会
  • Invited
• [Presentation] 『核内受容体が制御する多彩な生命現象』 LXRαの新規調節機構：TTC39B阻害はLXRαのユビキチン化によるプロテアソーム分解を減弱させアテローム性動脈硬化症および非アルコール性脂肪性肝炎の両方を改善する (2017)
  • Author(s): 小関正博
  • Organizer: 2017 年度生命科学系学会合同年次大会（第40 回日本分子生物学会年会、第90 回日本生化学会大会）(ConBio2017)
  • Invited
• [Remarks] 大阪大学 大学院医学系研究科 循環器内科学循環器脂質・動脈硬化グループ
  • URL: http://www.cardiology.med.osaka-u.ac.jp/?page_id=33160
• [Remarks] 家族性高コレステロール血症 大阪大学 大学院医学系研究科 循環器内科学 循環器脂質・動脈硬化研究室
  • URL: http://fh-osaka-univ.org/