Development of 3D photoacoustic CT with arc tran sducer for finger joint

• Project/Area Number: 17H02106
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: Tohoku University
• Principal Investigator: Saijo Yoshifumi 東北大学, 医工学研究科, 教授 (00292277)
• Co-Investigator(Kenkyū-buntansha): 松浦 祐司 東北大学, 医工学研究科, 教授 (10241530) ; 石井 智徳 東北大学, 大学病院, 特任教授 (10282138)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2017: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
• Keywords: 光音響イメージング / 関節リウマチ / 酸素飽和度 / 微小血管 / 慢性関節リウマチ / 高性能レーザー

Outline of Final Research Achievements

Principles of 3D photoacoustic CT were investigated in order to evaluate inflammatory activity of finger joints in rheumatoid arthritis visualized with photoacoustic signal produced by strong short pulsed light. Ultrasonic sensors were semicircularly arranged to fit the shape of finger and optical fibers were inserted to pass through the light. Laser or strong LED with two different wavelengths were illuminated. Precise algorithm for calculation of the oxygen saturation was developed considering the propagation of light in biological tissue. Finally, visualization of the human finger was successfully visualized by the photoacoustic CT.

Academic Significance and Societal Importance of the Research Achievements

関節リウマチの早期病変として、手の近位指節間関節、中手指節関節の滑膜の炎症が知られており、滑膜の炎症を血流の増加として可視化することで高精度で定量的な病変診断方法が可能である。光音響イメージングでは超音波ドプラ法では検出できないほどの遅い血流や細い血管を可視化できることから、指の形状に特化した光音響CTにより炎症の早期・精密診断が可能である。さらに、滑膜血流の酸素飽和度を計測することで炎症の活動性を評価し、関節リウマチの種々の治療薬の薬効評価方法への応用も可能である。

Research Products

• [Journal Article] Development of optical resolution photoacoustic microscopy with sub-micron lateral resolution for visualization of cells and their structures (2020)
  • Author(s): Shintate Ryo、Morino Taisuke、Kawaguchi Kota、Nagaoka Ryo、Kobayashi Kazuto、Kanzaki Makoto、Saijo Yoshifumi
  • Journal Title: Japanese Journal of Applied Physics Volume: 59 Issue: SK Pages: SKKE11-SKKE11
  • DOI: 10.35848/1347-4065/ab840e
  • Peer Reviewed
• [Journal Article] Correction of phase rotation in pulse spectrum method for scanning acoustic microscopy and its application to measurements of cells (2019)
  • Author(s): Nagaoka R, Kobayashi K, Arakawa M, Hasegawa H, Saijo Y
  • Journal Title: Ultrasonics Volume: 99 Pages: 105949-105949
  • DOI: 10.1016/j.ultras.2019.105949
  • Peer Reviewed
• [Journal Article] Basic study of improvement of axial resolution and suppression of time side lobe by phase-corrected Wiener filtering in photoacoustic tomography. (2018)
  • Author(s): Nagaoka Ryo, Yoshizawa Shin, Umemura ShinIchiro, Saijo Yoshifumi
  • Journal Title: Jpn J Appl Phys. Volume: 57 Issue: 7S1 Pages: 07LD11-07LD11
  • DOI: 10.7567/jjap.57.07ld11
  • NAID: 210000149310
  • Peer Reviewed
• [Journal Article] A theoretical model of laser heating carbon nanotubes. (2018)
  • Author(s): Siregar Syahril, Oktamuliani Sri, Saijo Yoshifumi.
  • Journal Title: Nanomaterials Volume: 8 Issue: 8 Pages: 580-580
  • DOI: 10.3390/nano8080580
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Optical resolution photoacoustic microscopy with fast laser scanning and fixed photoacoustic detector. (2018)
  • Author(s): Ishikawa Kodai, Shintate Ryo, Nagaoka Ryo, Saijo Yoshifumi
  • Journal Title: Conf Proc 39th IEEE Eng Med Biol Soc Volume: 1 Pages: 4800-4803
  • DOI: 10.1109/embc.2018.8513104
  • Peer Reviewed
• [Journal Article] A method for the design of ultrasonic devices for scanning acoustic microscopy using impulsive signals (2018)
  • Author(s): Arakawa Mototaka、Kanai Hiroshi、Ishikawa Kazuo、Nagaoka Ryo、Kobayashi Kazuto、Saijo Yoshifumi
  • Journal Title: Ultrasonics Volume: 84 Pages: 172-179
  • DOI: 10.1016/j.ultras.2017.10.023
  • Peer Reviewed
• [Journal Article] Visualization of murine lymph vessels using photoacoustic imaging with contrast agents (2018)
  • Author(s): Nagaoka Ryo、Tabata Takuya、Yoshizawa Shin、Umemura Shin-ichiro、Saijo Yoshifumi
  • Journal Title: Photoacoustics Volume: 9 Pages: 39-48
  • DOI: 10.1016/j.pacs.2018.01.001
  • Peer Reviewed / Open Access
• [Journal Article] Sparse-representation-based denoising of photoacoustic images (2017)
  • Author(s): Ul Haq Israr、Nagaoka Ryo、Siregar Syahril、Saijo Yoshifumi
  • Journal Title: Biomed Phys Eng Express Volume: 3 Issue: 4 Pages: 045014-045014
  • DOI: 10.1088/2057-1976/aa7a44
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 光音響イメージングによるVascular Healthの創生 (2019)
  • Author(s): 西條芳文
  • Organizer: 第30回日本医学会総会2019中部
  • Invited
• [Presentation] Photoacoustic Microscopy of Peripheral Circulation (2019)
  • Author(s): Saijo Y
  • Organizer: 2019 International Symposium of Frontier Acoustics
  • Int'l Joint Research / Invited
• [Presentation] Photoacoustic and ultrasound microscope for imaging of three-dimensional skin vasculature. (2018)
  • Author(s): Saijo Yoshifumi, Nagaoka Ryo, Shintate Ryo, Iwazaki Hideaki, Omuro Toshiyuki, Ida Taiishiro, Yoshizawa Shin, Umernura ShinIchiro
  • Organizer: III International Caparica conference on ultrasonic-based applications: from analysis to synthesis
  • Int'l Joint Research / Invited
• [Presentation] High frame rate photoacoustic imaging of micro vessel. (2018)
  • Author(s): Saijo Yoshifumi, Ishikawa Kodai, Shintate Ryo, Nagaoka Ryo
  • Organizer: 2018 Progress in Electromagnetics Research Symposium
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of skin aging with photoacoustic and ultrasound microscopy. (2018)
  • Author(s): Saijo Yoshifumi
  • Organizer: 12th ICME International Conference on Complex Medical Engineering
  • Int'l Joint Research / Invited
• [Presentation] Photoacoustic imaging of human skin with parabolic array transducer and tunable laser. (2017)
  • Author(s): Yoshifumi Saijo
  • Organizer: IEEE Engineering in Medicine and Biology Society
  • Int'l Joint Research / Invited
• [Presentation] High Frequency Ultrasound Imaging and its Recent Progress with Optics. (2017)
  • Author(s): Yoshifumi Saijo
  • Organizer: The International Conference on Biomedical Ultrasound 2017
  • Int'l Joint Research / Invited
• [Remarks] 西條研究室
  • URL: https://www.ecei.tohoku.ac.jp/imaging/index.htm
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/index.html
• [Remarks] Saijo Laboratory
  • URL: http://www.ecei.tohoku.ac.jp/imaging/index-e.html
• [Remarks] 西條研究室
  • URL: http://www.ecei.tohoku.ac.jp/imaging/index.htm