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Development of cell delivery system attaching flexible ultrasound array on body surface

Research Project

Project/Area Number 17H02107
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Masuda Kohji  東京農工大学, 工学(系)研究科(研究院), 教授 (60283420)

Co-Investigator(Kenkyū-buntansha) 丸山 一雄  帝京大学, 薬学部, 特任教授 (30130040)
鈴木 亮  帝京大学, 薬学部, 教授 (90384784)
Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Keywords音響放射力 / アレイトランスデューサ / 超音波 / 微小気泡 / 治療用細胞 / リンパ球 / 超音波音場 / トランスデューサ / Tリンパ球 / CD8陽性Tリンパ球 / 多分岐型流路 / 凝集体 / フレキシブルアレイ
Outline of Final Research Achievements

In order to apply to immune cell therapy, we have developed a technique for forming aggregates with bubble-surrounded cells (BSCs) and delivering cells in the bloodstream using acoustic radiation force. It is necessary to control the BSCs by irradiating the ultrasound field from various directions to aggregates in the fluid, focusing on the experimental results. With respect to damage to cells, not only the energy of ultrasound irradiation, but also sound pressure was found to be dominant. We constructed a theoretical model to trap aggregates on blood wall by ultrasound and compared it with the experimental results. Furthermore, it was displayed priority of the installation position of the sound source on the body surface. Using information on the surface of the actual human body, we have developed a therapy-planning software for the contact range of the sound source.

Academic Significance and Societal Importance of the Research Achievements

治療のために特別に調製した細胞、例えば活性化したNK細胞を患者に注入する治療法では、患者に対する副作用が少ないため、外科手術・化学療法・放射線療法に次ぐガン治療として注目されている。しかし血行性に輸注された細胞は基本的に全身に拡散するため、固形ガンなどの標的部位への集積効率には限界があることが問題である。そのため、本研究によって目的の細胞を標的部位に能動的に送達することができれば、注入量に対する効率を飛躍的に向上させることが期待できる。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (28 results)

All 2020 2019 2018 2017 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (19 results) (of which Int'l Joint Research: 7 results) Remarks (1 results)

  • [Journal Article] Detaching thin catheter from adhesion on blood vessel wall using acoustic radiation force with solid vibration2020

    • Author(s)
      Junya Takano, Yutaro Kobayashi, Hidetaka Ushimizu, Kansai Okadome, Takashi Mochizuki, and Kohji Masuda
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 59 Issue: SK Pages: SKKE22-SKKE22

    • DOI

      10.35848/1347-4065/ab8f0a

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Viability validation of therapeutic cells according to surrounded amount of microbubbles and ultrasound exposure condition2019

    • Author(s)
      Masakazu Seki, Takuya Otsuka, Riki Oitate, Kohji Masuda , Johan Unga, Ryo Suzuki, and Kazuo Maruyama
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 58 Issue: SG Pages: SGGE13-SGGE13

    • DOI

      10.7567/1347-4065/ab19ab

    • NAID

      210000156435

    • URL

      https://pure.teikyo.jp/en/publications/0b4c39ad-d3e4-4ff7-a9b2-535f6848e66b

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acoustic field sweeping for active induction of bubble-surrounded T-cells2018

    • Author(s)
      Oitate Riki、Otsuka Takuya、Seki Masakazu、Furutani Asuka、Mochizuki Takashi、Masuda Kohji、Suzuki Ryo、Maruyama Kazuo
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 57 Issue: 7 Pages: 07LF10-07LF10

    • DOI

      10.7567/jjap.57.07lf10

    • NAID

      210000149347

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Part 11. How to investigate acoustic radiation force with micro object2018

    • Author(s)
      MASUDA Kohji
    • Journal Title

      Choonpa Igaku

      Volume: 45 Issue: 2 Pages: 187-190

    • DOI

      10.3179/jjmu.JJMU.T.11

    • NAID

      130006496684

    • ISSN
      1346-1176, 1881-9311
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Towards <I>in vivo</I> delivery of microbubbles and cells using acoustic radiation force2018

    • Author(s)
      MASUDA Kohji、HOSAKA Naoto、DEMACHI Fumi、MIYAZAWA Shinya、SAWAGUCHI Toi、NATSUME Kaoru、MOCHIZUKI Takashi
    • Journal Title

      Choonpa Igaku

      Volume: 45 Issue: 2 Pages: 167-172

    • DOI

      10.3179/jjmu.JJMU.R.88

    • NAID

      130006496704

    • ISSN
      1346-1176, 1881-9311
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 音響放射力を利用した微小気泡及び細胞の生体内デリバリーを目指して2018

    • Author(s)
      桝田晃司、保坂直斗、出町文、宮澤慎也、澤口冬威、夏目薫、望月剛
    • Journal Title

      超音波医学

      Volume: 45 Pages: 167-172

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] B モードとドプラモードの両方に対応した血管分岐構造を有する超音波ファントムの製作2017

    • Author(s)
      木村允俊、片井拓弥、鈴木俊哉、山下智己、望月剛、桝田晃司、絵野沢伸
    • Journal Title

      生体医工学

      Volume: 55 Pages: 258-266

    • NAID

      130006581885

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of tracking performance of cell-bubble aggregation versus variation of acoustic field2017

    • Author(s)
      Riki Oitate, Akie Shimomura, Hikaru Wada, Takashi Mochizuki, Kohji Masuda, Yusuke Oda, Ryo Suzuki, and Kazuo Maruyama
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 56 Issue: 7 Pages: 07JF25-07JF25

    • DOI

      10.7567/jjap.56.07jf25

    • NAID

      210000148087

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Three-dimensional measurement of tip position of catheter in ultrasound volume through time-series analysis of microbubble dispersion2019

    • Author(s)
      Kosuke Kanda, Tatsuya Saito, Hidetaka Ushimizu, Kohji Masuda
    • Organizer
      The 2019 Biomedical Engineering International Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional extension of blood vessel network by combining multiple ultrasound volumes from different directions2019

    • Author(s)
      Takuya Katai, Ikumu Yasuda, Kosuke Watanabe, Kansai Okadome, Yoshihiro Edamoto, Shin Enosawa, and Kohji Masuda
    • Organizer
      IEEE Engineering in Medicine and Biology Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微小気泡-細胞凝集体の能動制御のための微小気泡破壊率の音波パラメータ依存性2019

    • Author(s)
      野﨑浄信、古谷飛鳥、桝田晃司、鈴木亮、丸山一雄
    • Organizer
      日本超音波医学会 第31 回関東甲信越地方会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Theoretical analysis of retention distribution of bubble surrounded cells with tempo spatial division emission2019

    • Author(s)
      Takuya Otsuka, Masakazu Seki , Kiyonobu Nozaki, Takumi Chikaarashi, Ryota Akutsu, Johan Unga, Kazuo Maruyama , Ryo Suzuki, and Kohji Masuda
    • Organizer
      40th Ultrasound Electronics Symposium
    • Related Report
      2019 Annual Research Report
  • [Presentation] 超音波音場形状に対する細胞-微小気泡凝集体の捕捉効果とその解析2019

    • Author(s)
      大塚拓也、関政和、追立理喜、桝田晃司、Johan Unga、鈴木亮、丸山一雄
    • Organizer
      日本超音波医学会 第92回学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Experimental study for active control of bubble- surrounded cells by acoustic radiation force with considering optimal production and cell viability2018

    • Author(s)
      Kohji Masuda, Takuya Otsuka, Masakazu Seki, Riki Oitate, Johan Unga, Ryo Suzuki, and Kazuo Maruyama
    • Organizer
      iEEE International Ultrasound Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Three-dimensional extension of blood vessel network based on extraction of blood vessel shape and the tree- structured analysis in ultrasound volume2018

    • Author(s)
      Takuya Katai, Ikumu Yasuda, Mitsutoshi Kimura, Yoshihiro Edamoto, and Kohji Masuda
    • Organizer
      Ultrasound Electronics Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Viability validation of therapeutic cells according to surrounded amount of microbubbles and ultrasound exposure condition2018

    • Author(s)
      Masakazu Seki, Takuya Otsuka, Riki Oitate, Kohji Masuda, Johan Unga, Ryo Suzuki, Kazuo Maruyama
    • Organizer
      Ultrasound Electronics Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fluorescent observation of microbubble behavior according to time division emission of multiple focal points considering blood vessel shape2018

    • Author(s)
      Kiyonobu Nozaki ,Asuka Furutani, Kosuke Watanabe, Takuya Katai, Kohji Masuda, Johan Unga, Ryo Suzuki, and Kazuo Maruyama
    • Organizer
      Ultrasound Electronics Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波ボリュームデータより再構成された3次元血管網構造の解析とCTデータとの比較2018

    • Author(s)
      安田育武,片井拓弥,木村允俊,小野木真哉,枝元良広,桝田晃司
    • Organizer
      日本コンピュータ外科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 血管分岐形状を利用した血管網の 3 次元拡張法の開発と超音波-CT 間の比較2018

    • Author(s)
      片井 拓弥,安田 育武,木村 允俊,山下 智己,小野木 真哉, 望月 剛,桝田 晃司,枝元 良広,絵野沢 伸
    • Organizer
      日本生体医工学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Active control of micro objects in blood vessel by forming tempo-spatial variation of acoustic field2018

    • Author(s)
      Kohji Masuda, Toshiya Suzuki, Riki Oitate, Hidetaka Ushimizu, Asuka Furutani, and Takashi Mochizuki
    • Organizer
      World Congress of Medical Physics and Biomedical Engineering
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波ボリューム中の血管分岐部の特徴を利用した 3 次元血管網の空間的拡張とその評価2017

    • Author(s)
      片井拓弥、木村允俊、山下智己、小野木真哉、望月剛、桝田晃司、枝元良広、篠崎雅史
    • Organizer
      第26回日本コンピュータ外科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 音響放射力による微小物体の血管内誘導のための超音波直交 2 断面のフィードバックと血管追従2017

    • Author(s)
      川本祥太郎、和田義久、木村允俊、小野木真哉、望月剛、桝田晃司
    • Organizer
      第26回日本コンピュータ外科学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Bモードとドプラモードの両方に対応した血管分岐構造を有する超音波ファントムの製作2017

    • Author(s)
      木村允俊、片井拓弥、鈴木俊哉、山下智己、望月剛、桝田晃司、絵野沢伸
    • Organizer
      生体医工学シンポジウム2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血管分岐点の空間分布を利用した3次元血管網の拡張と連結評価2017

    • Author(s)
      片井拓弥、山下智己、望月剛、桝田晃司
    • Organizer
      日本超音波医学会 第90回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 音響放射力分布の時間変化を利用したナノバブルの局所的濃度操作法の実験的検証2017

    • Author(s)
      古谷飛鳥、和田洸、鈴木俊哉、追立理喜、望月剛、桝田晃司、Johan Unga、小田雄介、鈴木亮、丸山一雄
    • Organizer
      日本超音波医学会 第90回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Bモード及びドプラモードボリューム中の3次元血管構造の比較検証のためのファントムの製作2017

    • Author(s)
      木村允俊、山下智己、望月剛、桝田晃司、絵野沢伸
    • Organizer
      日本超音波医学会 第90回学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 音場分布の空間移動に対する細胞-微小気泡凝集体の挙動観測とその解析2017

    • Author(s)
      追立理喜、下村明栄、和田洸、望月剛、桝田晃司、小田雄介、鈴木亮、丸山一雄
    • Organizer
      第56回日本生体医工学会大会
    • Related Report
      2017 Annual Research Report
  • [Remarks] 東京農工大学 大学院生物システム応用科学府 桝田研究室

    • URL

      http://www.tuat.ac.jp/~masuda

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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