| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
We investigated the effect of neuromuscular electrical stimulation (ES) with passive motion (PM) on ICU-acquired weakness (ICUAW). Animal studies using steroid-denervation (SD) and denervation (DEN) rats revealed that impaired membrane excitability and myofibrillar dysfunction are two major cellular defects underlying ICUAW that are likely to be caused by mechanical silencing. Importantly, ES training ameliorated the SD- and DEN-induced myofibrillar dysfunction, whereas these beneficial effects of ES were not enhanced by a combination of ES and PM. On the basis of these findings, we examined the effect of ES training on patients with ICUAW and found a trend towards prevention of reduction in torque production. Further data collection is planned to reach statistical power.
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