Neural circuit of motivation for rehabilitation

• Project/Area Number: 17H02126
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Institute of Advanced Industrial Science and Technology (2020); Okinawa Institute of Science and Technology Graduate University (2017-2019)
• Principal Investigator: HIKISHIMA KEIGO 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (30420219)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: 非侵襲イメージング / MRI / 超音波

Outline of Final Research Achievements

The goal of this study is to elucidate the neural mechanisms of the ventral tegmental area and nucleus accumbens involved in motivation, and to propose a new neurorehabilitation method that efficiently promotes functional recovery by strengthening this "motivational circuit". In this study, we have developed functional brain imaging for this purpose.

Academic Significance and Societal Importance of the Research Achievements

脳深部にある内側前脳束の電気刺激は、その軸索の投射先でドーパミンを分泌させ、報酬作用が働くと考えられている。しかし、報酬系刺激時の全脳的な脳活動についてはあまり知られていない。本研究で開発した脳機能イメージングは、報酬系刺激時の脳活動の解明に貢献することができる。

Research Products

• [Journal Article] Measurement of baseline locomotion and other behavioral traits in a common marmoset model of Parkinson's disease established by a single administration regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (2020)
  • Author(s): Ando Kiyoshi、Inoue Takashi、Hikishima Keigo、Komaki Yuji、Kawai Kenji、Inoue Ryo、Nishime Chiyoko、Nishinaka Eiko、Urano Koji、Okano Hideyuki
  • Journal Title: Behavioural Pharmacology Volume: 31 Issue: 1 Pages: 45-60
  • DOI: 10.1097/fbp.0000000000000509
  • Peer Reviewed
• [Journal Article] The Brain/MINDS 3D digital marmoset brain atlas (2018)
  • Author(s): Woodward A, Hashikawa T, Maeda M, Kaneko T, Hikishima K, Iriki A, Okano H, Yamaguchi Y.
  • Journal Title: Sci Data Volume: 5 Issue: 1 Pages: 180009-180009
  • DOI: 10.1038/sdata.2018.9
  • Peer Reviewed / Open Access
• [Journal Article] Visualization of nerve fibers around the carotid bifurcation with use of a 9.4 Tesla microscopic magnetic resonance diffusion tensor imaging with tractography (2018)
  • Author(s): Saito Shin、Ozawa Hiroyuki、Fujioka Masato、Hikishima Keigo、Hata Junichi、Kurihara Sho、Okano Hirotaka James、Ogawa Kaoru
  • Journal Title: Head & Neck Volume: 40 Issue: 10 Pages: 2228-2234
  • DOI: 10.1002/hed.25318
  • Peer Reviewed
• [Journal Article] Developmental trajectories of macroanatomical structures in common marmoset brain (2017)
  • Author(s): Seki Fumiko、Hikishima Keigo、Komaki Yuji、Hata Junichi、Uematsu Akiko、Okahara Norio、Yamamoto Masafumi、Shinohara Haruka、Sasaki Erika、Okano Hideyuki
  • Journal Title: Neuroscience Volume: 364 Pages: 143-156
  • DOI: 10.1016/j.neuroscience.2017.09.021
  • Peer Reviewed
• [Journal Article] 2. Development of Neuroimaging Using Preclinical MRI, and the Clinical Application (2017)
  • Author(s): 疋島啓吾、藤吉兼浩
  • Journal Title: Japanese Journal of Radiological Technology Volume: 73 Issue: 12 Pages: 1277-1284
  • DOI: 10.6009/jjrt.2017_JSRT_73.12.1277
  • NAID: 130006258038
  • ISSN: 0369-4305, 1881-4883
• [Presentation] 非侵襲イメージングによる全体からの視点 (2021)
  • Author(s): 疋島 啓吾
  • Organizer: 第98回日本生理学会大会
  • Invited
• [Presentation] マルチスケールデータ統合のための非侵襲全脳イメージングの開発 (2020)
  • Author(s): 疋島 啓吾
  • Organizer: 第一回フィジオメレオロジー研究会
  • Invited
• [Presentation] MRI neuroimaging of rodents and marmoset monkeys (2018)
  • Author(s): Keigo Hikishima
  • Organizer: International Research Center for Neurointelligence Workshop
  • Invited