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Revealing development of motor functions during golden ages

Research Project

Project/Area Number 17H02143
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionNational Institute of Information and Communications Technology

Principal Investigator

Naito Eiichi  国立研究開発法人情報通信研究機構, 脳情報通信融合研究センター脳情報通信融合研究室, 研究マネージャー (10283293)

Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywords運動機能発達 / ゴールデンエイジ / 大脳小脳連関 / 機能的磁気共鳴装置 / 機能分化 / 半球間抑制 / 巧緻性の発達 / internal feedback / 小脳虫部 / 運動機能 / 発達 / 運動野 / 体部位再現 / 活動抑制 / クロスモダル抑制 / 脳機能分化 / 磁気共鳴画像装置 / 体部位間抑制 / 活動の限局化 / 機能的MRI / 拡散強調MRI / 機能的磁気共鳴画像装置 / 大脳-小脳連関 / 運動の協調 / 自己(固有)受容感覚 / 運動錯覚 / 自己顔認知 / 右半球 / 上縦束第3ブランチ / 身体認知 / ヒト脳機能発達 / 身体性の脳科学 / スポーツ脳科学
Outline of Final Research Achievements

In this study, we used MRI to visualize how the brain develops motor functions during the so-called "golden age" of elementary school. In the motor cortex, we found that interhemispheric inhibition and cross-somatotopic inhibition develop from elementary to junior high school, suggesting that functional differentiation of somatotopic body representation matures during adolescence. As for the cerebro-cerebellar network, we showed that functional connectivity within local region is still strong in elementary school children, and the connectivity between the motor cortex and the cerebellum is enhanced along with development in association with cerebro-cerebellar fiber maturation.

Academic Significance and Societal Importance of the Research Achievements

運動機能はヒトの生存にとって本質的であるが、これまで、運動機能を支える脳の発達に関する知見は乏しかった。本研究は、運動野で起こる機能分化や大脳-小脳連関の発達などに関して、世界初の貴重な知見を数多く明らかにし、これらを国際科学雑誌で公表するとともに、多くの講演や総説などでその成果を積極的に社会に還元した。本研究は、運動システム脳科学を重厚化させ、スポーツトレーニングの指針にもなりうる基礎脳科学の知見を数多く提供することに成功した。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (46 results)

All 2021 2020 2019 2018 2017

All Journal Article (18 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 12 results,  Acknowledgement Compliant: 1 results) Presentation (24 results) (of which Int'l Joint Research: 4 results,  Invited: 20 results) Book (4 results)

  • [Journal Article] Examination of the development and aging of brain deactivation using a unimanual motor task2021

    • Author(s)
      Morita T, Asada M and Naito E
    • Journal Title

      Advanced Robotics

      Volume: ― Issue: 13-14 Pages: 1-16

    • DOI

      10.1080/01691864.2021.1886168

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age dependency and lateralization in the three branches of the human superior longitudinal fasciculus2021

    • Author(s)
      Amemiya K, Naito E and Takemura H
    • Journal Title

      Cortex

      Volume: 139 Pages: 116-133

    • DOI

      10.1016/j.cortex.2021.02.027

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Grey matter expansion of social brain networks in individuals high in public self-consciousness2021

    • Author(s)
      Morita T, Asada M and Naito E
    • Journal Title

      Brain Sciences

      Volume: ― Issue: 3 Pages: 374-374

    • DOI

      10.3390/brainsci11030374

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Importance of the Primary Motor Cortex in Development of Human Hand/Finger Dexterity2020

    • Author(s)
      Naito Eiichi、Morita Tomoyo、Asada Minoru
    • Journal Title

      Cerebral Cortex Communications

      Volume: online ahead of print Issue: 1 Pages: 1-12

    • DOI

      10.1093/texcom/tgaa085

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 運動の巧みさは脳のどこが担うのか2020

    • Author(s)
      内藤栄一、守田知代、廣瀬智士
    • Journal Title

      Clinical Neuroscience誌 月刊臨床神経科学 特集 スポーツの神経科学

      Volume: 38 Pages: 715-719

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 運動制御の発達を支える脳機能の役割2020

    • Author(s)
      内藤栄一、守田知代
    • Journal Title

      特集 運動技能を支える神経メカニズムの新知見 体育の科学

      Volume: 70 Pages: 783-788

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Right-hemispheric dominance in self-body recognition is altered in left-handed individuals2020

    • Author(s)
      Morita T, Asada M, Naito E
    • Journal Title

      Neuroscience

      Volume: 425 Pages: 68-89

    • DOI

      10.1016/j.neuroscience.2019.10.056

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurological and behavioral features of locomotor imagery in the blind2020

    • Author(s)
      Amemiya K, Morita T, Hirose S, Ikegami T, Hirashima M, Naito E
    • Journal Title

      Brain Imaging and Behavior

      Volume: - Issue: 2 Pages: 656-676

    • DOI

      10.1007/s11682-020-00275-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental changes in task-induced brain deactivation in humans revealed by a motor task2019

    • Author(s)
      Morita T, Asada M, Naito E
    • Journal Title

      Developmental Neurobiology

      Volume: 79 Issue: 6 Pages: 536-558

    • DOI

      10.1002/dneu.22701

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Local-to-distant development of the cerebrocerebellar sensorimotor network in the typically developing human brain: a functional and diffusion MRI study2019

    • Author(s)
      Amemiya Kaoru、Morita Tomoyo、Saito Daisuke N.、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru、Naito Eiichi
    • Journal Title

      Brain Structure and Function

      Volume: in press Issue: 3 Pages: 1359-1375

    • DOI

      10.1007/s00429-018-01821-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical activation associated with motor preparation can be used to predict the freely chosen effector of an upcoming movement and reflects response time: An fMRI decoding study2018

    • Author(s)
      Hirose Satoshi、Nambu Isao、Naito Eiichi
    • Journal Title

      NeuroImage

      Volume: 183 Pages: 584-596

    • DOI

      10.1016/j.neuroimage.2018.08.060

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] アスリートのfMRI:ネイマール選手の脳の効率的な足運動制御2018

    • Author(s)
      内藤栄一
    • Journal Title

      Clinical Neuroscience誌 月刊臨床神経科学

      Volume: 36 Pages: 1227-1230

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Self-Face Recognition Begins to Share Active Region in Right Inferior Parietal Lobule with Proprioceptive Illusion During Adolescence2018

    • Author(s)
      Morita Tomoyo、Saito Daisuke N、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru、Naito Eiichi
    • Journal Title

      Cerebral Cortex

      Volume: 28 Issue: 4 Pages: 1532-1548

    • DOI

      10.1093/cercor/bhy027

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Right-hemispheric Dominance of Inferior Parietal Lobule in Proprioceptive Illusion Task2017

    • Author(s)
      Naito Eiichi、Morita Tomoyo、Saito Daisuke N、Ban Midori、Shimada Koji、Okamoto Yuko、Kosaka Hirotaka、Okazawa Hidehiko、Asada Minoru
    • Journal Title

      Cerebral Cortex

      Volume: 27 Issue: 11 Pages: 5385-5397

    • DOI

      10.1093/cercor/bhx223

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-face recognition shares brain regions active during proprioceptive illusion in the right inferior fronto-parietal superior longitudinal fasciculus III network.2017

    • Author(s)
      Morita T, Saito DN, Ban M, Shimada K, Okamoto Y, Kosaka H, Okazawa H, Asada M, Naito E
    • Journal Title

      Neuroscience

      Volume: 348 Pages: 288-301

    • DOI

      10.1016/j.neuroscience.2017.02.031

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 固有感覚2017

    • Author(s)
      内藤栄一、雨宮薫、守田知代
    • Journal Title

      Clinical Neuroscience誌 月刊臨床神経科学

      Volume: 35 Pages: 140-144

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 脳科学からみた脳内身体表現への介入2017

    • Author(s)
      内藤栄一
    • Journal Title

      計測と制御

      Volume: 56 Pages: 169-174

    • NAID

      130005457909

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 超一流サッカー選手の脳活動の特殊性2017

    • Author(s)
      内藤栄一
    • Journal Title

      計測と制御

      Volume: 56 Pages: 588-594

    • NAID

      130005982837

    • Related Report
      2017 Annual Research Report
  • [Presentation] Negative BOLD現象の発達変化から推測する脳の抑制機構の発達と機能分化2020

    • Author(s)
      内藤栄一
    • Organizer
      JST戦略的創造研究推進事業 (CREST) 脳領域/個体/集団間のインタラクション創発原理の解明と適用 Zoom講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 小脳の発達変化から考察するヒトの運動機能発達2020

    • Author(s)
      内藤栄一
    • Organizer
      JST戦略的創造研究推進事業 (CREST) 脳領域/個体/集団間のインタラクション創発原理の解明と適用 Zoom講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 人の脳内身体表現の発達2020

    • Author(s)
      内藤栄一
    • Organizer
      Motor Control研究会 Zoom講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 脳内身体表現の理解と応用2020

    • Author(s)
      内藤栄一
    • Organizer
      新化学技術推進協会 ライフサイエンス技術部会 脳科学分科会 講演会 Zoom講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 人の脳内身体表現の理解と応用2020

    • Author(s)
      内藤栄一
    • Organizer
      応用脳科学アカデミー&ワークショップ アドバンスコース「ブレインヘルスケアとリハビリテーション」第1回 講演会 Zoom講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Lifespan change in asymmetry of superior longitudinal2019

    • Author(s)
      Kaoru Amemiya , Eiichi Naito , Hiromasa Takemura
    • Organizer
      OHBM2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Local-to-distant development of cerebrocerebellar sensorimotor network in human brain2019

    • Author(s)
      Eiichi Naito, Kaoru Amemiya, Tomoyo Morita, Daisuke N. Saito, Midori Ban, Koji Shimada, Yuko Okamoto, Hirotaka Kosaka, Hidehiko Okazawa, Minoru Asada
    • Organizer
      OHBM2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 身体運動が創発する脳の発達、特殊化と機能改善2019

    • Author(s)
      内藤栄一
    • Organizer
      第27回脳の世紀シンポジウム 運動/スポーツと脳
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳を知り、脳を活かす -脳内身体表現の理解と応用-2019

    • Author(s)
      内藤栄一
    • Organizer
      情報通信研究機構研究講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳内身体表現と運動制御のシステム2019

    • Author(s)
      内藤栄一
    • Organizer
      第37回日本感覚統合学会姫路大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 一流サッカー選手とブラインドサッカー選手の脳から考える神経系の適応と超適応2019

    • Author(s)
      内藤栄一
    • Organizer
      日本学術会議公開シンポジウム「スポーツと脳科学」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 脳を知り、脳を活かす -脳内身体表現の理解と応用-2019

    • Author(s)
      内藤栄一
    • Organizer
      九州ICTセミナー2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Development of Right Hemispheric Dominance in Self-Body Recognition Tasks2018

    • Author(s)
      Morita T, Saito DN, Ban M, Shimada K, Okamoto Y, Kosaka H, Okazawa H, Asada M and Naito E
    • Organizer
      Human Brain Mapping2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of right-hemispheric dominance of inferior parietal lobule in proprioceptive illusion2018

    • Author(s)
      Naito E*, Morita T, Saito DN, Ban M, Shimada K, Okamoto Y, Kosaka H, Okazawa H and Asada M
    • Organizer
      Human Brain Mapping2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超一流サッカー選手の脳活動の特殊性2018

    • Author(s)
      内藤栄一
    • Organizer
      第59回日本神経学会学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 自己受容感覚の運動制御と自己身体認知への貢献2018

    • Author(s)
      内藤栄一
    • Organizer
      日本リハビリテーション医学会 第44回北陸地方会生涯教育研修会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 運動機能の発達、洗練化、劣化の脳内神経基盤2018

    • Author(s)
      内藤栄一
    • Organizer
      第1回CiNet脳情報研究WS
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 自己受容感覚から形成される脳内身体表現とその発達2018

    • Author(s)
      内藤栄一
    • Organizer
      日本ボバース研究会 北海道ブロック 第15回症例発表会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 自己受容感覚から形成される脳内身体表現とその発達2018

    • Author(s)
      内藤栄一
    • Organizer
      BINI perspective conference
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 自己受容感覚から形成される脳内身体表現2017

    • Author(s)
      内藤栄一
    • Organizer
      第日本ボバース研究会関東甲信越神ブロック合同症例発表会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 右半球下前頭-頭頂SLFIIIネットワークの身体認知と自己認知への関与と発達2017

    • Author(s)
      内藤栄一
    • Organizer
      東北大学肢体不自由学分野メジャーセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 身体運動および身体認知機能を担う人間の脳活動の可塑的変化2017

    • Author(s)
      内藤栄一
    • Organizer
      本田技術研究所セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 身体図式と脳活動2017

    • Author(s)
      内藤栄一
    • Organizer
      日本ボバース研究会東北ブロック症例検討会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 自己受容感覚から形成される脳内身体表現2017

    • Author(s)
      内藤栄一
    • Organizer
      山梨県リハビリテーション専門職合同学術大会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Book] 連合野ハンドブック2021

    • Author(s)
      1.内藤栄一、守田知代
    • Total Pages
      11
    • Publisher
      医学書院
    • ISBN
      9784260043434
    • Related Report
      2020 Annual Research Report
  • [Book] 身体性システムとリハビリテーションの科学1 運動制御2018

    • Author(s)
      関和彦、内藤栄一
    • Total Pages
      32
    • Publisher
      東京大学出版会
    • Related Report
      2018 Annual Research Report
  • [Book] 脳の神秘を探ってみよう2017

    • Author(s)
      内藤栄一
    • Total Pages
      12
    • Publisher
      朝日新聞出版
    • ISBN
      9784023315839
    • Related Report
      2017 Annual Research Report
  • [Book] 手の百科事典2017

    • Author(s)
      内藤栄一
    • Total Pages
      5
    • Publisher
      朝倉書店
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2022-01-27  

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