Effects of exercise under hypoxic condition: Influence of different types of muscle contraction

• Project/Area Number: 17H02155
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sports science
• Research Institution: Ritsumeikan University
• Principal Investigator: GOTO KAZUSHIGE 立命館大学, スポーツ健康科学部, 教授 (60508258)
• Co-Investigator(Kenkyū-buntansha): 片山 敬章 名古屋大学, 総合保健体育科学センター, 教授 (40343214)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
• Keywords: 低酸素 / 有酸素性運動 / ペダリング運動 / ランニング運動 / 筋収縮様式 / 糖代謝 / 低酸素トレーニング / 伸張性活動 / 筋酸素動態 / 伸張性筋活動 / 短縮性筋活動 / インスリン感受性 / スポーツ科学 / トレーニング科学

Outline of Final Research Achievements

Both cycling exercise and running exercise augmented carbohydrate metabolism compared with the same exercise in normoxia. Moreover, endurance exercise in hypoxia promoted muscle metabolism (muscle oxygen consumption). The findings from the present results suggest that endurance exercise in hypoxia facilitated carbohydrate metabolism with being independent of exercise modality (muscle contraction type).

Academic Significance and Societal Importance of the Research Achievements

中程度の低酸素環境で実施する有酸素性運動が糖代謝を亢進させることが明らかになった。また、この効果は、ペダリング運動とランニング運動の双方で認められた。したがって、糖代謝の改善（インスリン感受性の改善など）をねらいとして低酸素環境での有酸素性運動を導入する際には、運動様式（筋の収縮様式）を問わずに代謝改善効果を期待できると考えられる。

Research Products

• [Int'l Joint Research] School of Psychology/and Exercise Science/Murdoch University(オーストラリア)
• [Journal Article] Acute Performance and Physiological Responses to Repeated-Sprint Exercise in a Combined Hot and Hypoxic Environment. (2020)
  • Author(s): Yamaguchi K, Kasai N, Hayashi N, Yatsutani H, Girard O, Goto K
  • Journal Title: Physiological Reports Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exogenous glucose oxidation during endurance exercise in hypoxia. (2020)
  • Author(s): Sumi D, Hayashi N, Yatsutani H and Goto K
  • Journal Title: Physiological Reports Volume: -
  • Peer Reviewed / Open Access
• [Journal Article] No effect of supplemented heat stress during an acute endurance exercise session in hypoxia on hepcidin regulation. (2020)
  • Author(s): Hayashi N, Yatsutani H, Mori H, Ito H, Badenhorst CE, Goto K
  • Journal Title: European Journal of Applied Physiology Volume: - Issue: 6 Pages: 1331-1340
  • DOI: 10.1007/s00421-020-04365-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Inflammatory, oxidative stress, and angiogenic growth factor responses to repeated-sprint exercise in hypoxia. (2019)
  • Author(s): Kasai N, Kojima C, Sumi D, Ikutomo A, Goto K
  • Journal Title: Frontiers in Physiology Volume: 10 Pages: 844-844
  • DOI: 10.3389/fphys.2019.00844
  • Peer Reviewed / Open Access
• [Journal Article] Muscle oxygenation during repeated double-poling sprint exercise in normobaric hypoxia and normoxia. (2019)
  • Author(s): Yamaguchi K, Kasai N, Sumi D, Yatsutani H, Girard O, Goto K
  • Journal Title: Frontiers in Physiology Volume: 10 Pages: 743-743
  • DOI: 10.3389/fphys.2019.00743
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Effects of Endurance Exercise in Hypoxia on Acid-base Balance, Potassium Kinetics and Exogenous Glucose Oxidation. (2019)
  • Author(s): Sumi D, Kasai N, Ito H, Goto K.
  • Journal Title: Frontiers in Physiology Volume: 10 Pages: 504-504
  • DOI: 10.3389/fphys.2019.00504
  • Peer Reviewed / Open Access
• [Journal Article] The effects of endurance exercise in hypoxia on acid-base balance and potassium kinetics: a randomized crossover design in male endurance athletes. (2018)
  • Author(s): Sumi D, Kojima C, Kasai N, Goto K.
  • Journal Title: Sports Medicine-Open Volume: 4 Issue: 1 Pages: 45-45
  • DOI: 10.1186/s40798-018-0160-1
  • Peer Reviewed / Open Access
• [Journal Article] Metabolic and Performance Responses to Sprint Exercise under Hypoxia among Female Athletes. (2018)
  • Author(s): Kasai N, Kojima C, Goto K
  • Journal Title: Sports Medicine International Open Volume: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Appetite regulations after high-intensity interval exercise under hypoxic condition in female athletes. (2018)
  • Author(s): Kojima C, Kasai N, Ishibashi A, Murakami Y, Ebi K, Goto K
  • Journal Title: Journal of Strength Conditioning Research Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Impact of 6 consecutive days of sprint training in hypoxia on performance in competitive sprinters. (2018)
  • Author(s): Kasai N, Mizuno S, Ishimoto S, Sakamoto E, Maruta M, Kurihara T, Kurosawa Y, Goto K
  • Journal Title: Journal of Strength and Conditioning Research Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Impact of Endurance Exercise in Hypoxia on Muscle Damage, Inflammatory and Performanc Responses. (2018)
  • Author(s): Sumi D, Kojima C, Goto K
  • Journal Title: Journal of Strength and Conditioning Research Volume: 32 Issue: 4 Pages: 1053-1062
  • DOI: 10.1519/jsc.0000000000001911
  • Peer Reviewed
• [Journal Article] Post-exercise serum hepcidin response to repeated sprint exercise under normoxic and hypoxic conditions. (2018)
  • Author(s): Goto K, Kasai N, Kojima C, Ishibashi A
  • Journal Title: Applied Physiology, Nutrition, and Metabolism Volume: 43 Issue: 3 Pages: 221-226
  • DOI: 10.1139/apnm-2017-0418
  • Peer Reviewed
• [Journal Article] Impact of inserted long rest periods during repeated sprint exercise on performance adaptation. (2018)
  • Author(s): Ikutomo A, Kasai N, Goto K
  • Journal Title: European Journal of Sports Science Volume: 18 Issue: 1 Pages: 47-53
  • DOI: 10.1080/17461391.2017.1383515
  • Peer Reviewed
• [Journal Article] Impact of 5 days of sprint training in hypoxia on performance and muscle energy substances. (2017)
  • Author(s): Kasai N, Kojima C, Sumi D, Takahashi H, Goto K, Suzuki Y
  • Journal Title: International Journal of Sports Medicine Volume: 38 Issue: 13 Pages: 983-991
  • DOI: 10.1055/s-0043-117413
  • Peer Reviewed
• [Journal Article] Wearing compression tights on the thigh during prolonged running attenuated exercise-induced increase in muscle damage marker in blood. (2017)
  • Author(s): Mizuno S, Arai M, Tdoko F, Yamada E, Goto K
  • Journal Title: Frontiers in Physiology Volume: 8 Pages: 834-834
  • DOI: 10.3389/fphys.2017.00834
  • Peer Reviewed / Open Access
• [Journal Article] Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. (2017)
  • Author(s): Goto K, Sumi D, Kojima C, Ishibashi A
  • Journal Title: PLOS ONE Volume: 12
  • Peer Reviewed / Open Access
• [Journal Article] Iron supplementation during 3 consecutive days of endurance training augmented hepcidin level. (2017)
  • Author(s): Ishibashi A, Maeda N, Kamei A, Goto K
  • Journal Title: Nutrients Volume: 9 Issue: 8 Pages: 820-820
  • DOI: 10.3390/nu9080820
  • Peer Reviewed / Open Access
• [Presentation] 低酸素環境や暑熱環境下で行う運動に対する代謝応答. (2019)
  • Author(s): 後藤一成
  • Organizer: 第27回日本運動生理学会大会
  • Invited
• [Presentation] 低酸素トレーニングに関わる新たな試み (2019)
  • Author(s): 後藤一成
  • Organizer: 第74回日本体力医学会大会
  • Invited
• [Presentation] Exogenous glucose oxidaiton duirng endurance exercise in hypoxia. (2019)
  • Author(s): Sumi D, Hayashi N, Yatsutani H, Goto K
  • Organizer: 66th Annual Meeting of American College of Sports Medicine
  • Int'l Joint Research
• [Presentation] Effects of endurance exercise in heat and hypoxia on hepcidin responses. (2019)
  • Author(s): Hayashi N, Yatsutani H, Mori H, Ito H, Goto K
  • Organizer: 66th Annual Meeting of American College of Sports Medicine
  • Int'l Joint Research
• [Presentation] Impact of Hypoxia on Glucose Metabolism, Appetite Regulations, Muscle Damage and Inflammatory Responses (2018)
  • Author(s): Goto K
  • Organizer: 65th Annual Meeting of American College of Sports Medicine
  • Int'l Joint Research
• [Presentation] Muscle oxygenation and systemic metabolic responses during maximal sprint exercise in hypoxia among athletes (2018)
  • Author(s): Kasai N, Motomura Y, Ikutomo A, Goto K
  • Organizer: 65th Annual Meeting of American College of Sports Medicine
  • Int'l Joint Research
• [Presentation] The effects of endunrace exercise in hypoxia on hepcidin response in athletes (2018)
  • Author(s): Sumi D, Kojima C, Goto K
  • Organizer: 65th Annual Meeting of American College of Sports Medicine
  • Int'l Joint Research
• [Presentation] Muscle exygenation during repeated double-poling sprint exercise under hypoxic condition (2018)
  • Author(s): Yamaguchi K, Kasai N, Sumi D, Yatsutani H, Goto K
  • Organizer: 65th Annual Meeting of American College of Sports Medicine
  • Int'l Joint Research
• [Presentation] 高強度や長時間の運動が食欲調節に及ぼす影響ー運動に伴う食欲減退とその打開策ー (2018)
  • Author(s): 後藤一成
  • Organizer: 第73回日本体力医学会大会
  • Invited
• [Presentation] 高強度運動が食欲に及ぼす影響-運動後における食欲減退の機序とその対策- (2017)
  • Author(s): 後藤一成
  • Organizer: ストレングス&コンディショニングカンファレンス2017
  • Invited
• [Presentation] 高強度トレーニング時における栄養摂取が代謝・内分泌指標や運動パフォーマンスに及ぼす影響 (2017)
  • Author(s): 後藤一成
  • Organizer: 第64回栄養改善学会
  • Invited
• [Presentation] 低酸素環境下での高強度運動に対する代謝・内分泌動態 (2017)
  • Author(s): 後藤一成
  • Organizer: 第21回酸素ダイナミクス研究会
  • Invited
• [Funded Workshop] International Seminar of Sports Science between Japan and Korea (2018)