| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
In this research project, we established the separation analytical method of the prostanoids by mass spectrometry and mass spectrometry imaging. As a result of examination using the tail-suspension model in in vivo, the data was shown that the production of prostanoid from the immune system cells participated in muscular atrophy. In the examination using the inhibitor of prostanoids production, an improvement effect of the muscular atrophy was observed. These data indicated that prostanoids regulated progression of muscular atrophy in the model of disuse diseases.
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