Identification of the target molecules using imaging mass spectrometry analysis of prostanoids on muscular atrophy.
| Project/Area Number |
17H02157
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
INADA MASAKI 東京農工大学, 工学(系)研究科(研究院), 准教授 (80401454)
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 克彦 早稲田大学, スポーツ科学学術院, 教授 (80344597)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 廃用性筋萎縮 / プロスタノイド / 筋萎縮 / 筋萎縮とプロスタノイド / スポーツ生化学 |
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| Outline of Final Research Achievements |
In this research project, we established the separation analytical method of the prostanoids by mass spectrometry and mass spectrometry imaging. As a result of examination using the tail-suspension model in in vivo, the data was shown that the production of prostanoid from the immune system cells participated in muscular atrophy. In the examination using the inhibitor of prostanoids production, an improvement effect of the muscular atrophy was observed. These data indicated that prostanoids regulated progression of muscular atrophy in the model of disuse diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究課題の実施により、質量分析および質量分析イメージングによるプロスタノイドの解析基盤を確立した。さらに、廃用性筋萎縮の進行にはプロスタノイドが関与することを明らかとした。将来の廃用性筋萎縮やサルコペニア、ロコモティブシンドロームの治療につながる分子標的としてのプロスタノイド産生阻害剤の開発や遺伝子治療、天然由来機能性因子を活用し、新規な治療薬や治療因子の開発につなげてゆきたい。
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Hypergravity and microgravity exhibited reversal effects on the bone and muscle mass in mice.2019
Author(s)
Tominari T, Ichimaru R, Taniguchi K, Yumoto A, Shirakawa M, Matsumoto C, Watanabe K, Hirata M, Itoh Y, Shiba D, Miyaura C, Inada M
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Journal Title
Sci Rep
Volume: 9(1)
Issue: 1
Pages: 6614-6614
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Beta-cryptoxanthin inhibits lipopolysaccharide-induced osteoclast differentiation and bone resorption via the suppression of inhibitor of NF-κB kinase activity.2019
Author(s)
Hirata N , Ichimaru R , Tominari T , Matsumoto C, Watanabe K ,Taniguchi K , Hirata M , Ma S, Suzuki K , Grundler FM , Miyaura C, Inada M
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Journal Title
Nutrients
Volume: 11
Issue: 2
Pages: 368-368
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Structure-activity relationship of anthocyanidins as an inhibitory effect on osteoclast differentiation.2018
Author(s)
Hirata N, Tominari T, Ichimaru R, Taniguchi K, Matsumoto C, Watanabe K, Hirata M, Ma S, Suzuki K, Grundler FM, Miyaura C, Inada M
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Journal Title
BPB_Reports
Volume: 2
Pages: 1-6
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis.2018
Author(s)
Ichimaru R, Tominari T, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Numabe Y, Murphy G, Nagase H,Miyaura C, Inada M
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Journal Title
Arch. Oral Biol
Volume: 85
Pages: 98-103
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis.2018
Author(s)
Ichimaru R, Tominari T, Yoshinouchi S, Matsumoto C, Watanabe K, Hirata M, Numabe Y, Murphy G, Nagase H, Miyaura C, Inada M
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Journal Title
Arch. Oral Biol.
Volume: 85
Pages: 98-103
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption.2017
Author(s)
Watanabe K, Tominari T, Hirata M, Matsumoto C, Hirata J, Murphy G, Nagase H, Miyaura C, Inada M
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Journal Title
FEBS Open Bio.
Volume: 7
Pages: 1178-1185
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] Schumann, M., Rφnnestad, B., Eds. Concurrent Aerobic and Strength Training: Scientific Basics and Practical Applications.2019
Author(s)
Goh, J.M., Lim, C.L., Suzuki, K. Effects of endurance-, strength-, and concurrent training on cytokines and inflammation
Total Pages
14
Publisher
Springer, Germany
ISBN
9783319755465
Related Report
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