| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Outline of Final Research Achievements |
Skeletal muscle is constantly exposed to physical force including exercise or mechanical stretch. Testosterone is converted into its bioactive metabolite dihydrotestosterone (DHT) by 5α-reductase (srd5a1). DHT is also involved in exercise-induced skeletal muscular metabolism. However, it remains to be elucidated whether muscular DHT production through srd5a1 is locally involved in skeletal muscular plasticity. Here we found that local DHT production in skeletal muscle inhibited muscular atrophy through the suppression of atrophy-related gene expression. We show that mechanical stretch transactivates an androgenic enzyme, srd5a1 through the binding of early growth response 2 (Egr2) in skeletal muscle. These results suggest that bioactive androgen metabolism through the Egr2-srd5a1 axis could play important roles in maintaining muscle mass in mechanical stretch.
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