Cognitive neuroscientific approach to gait and positive thinking

• Project/Area Number: 17H02173
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: Makiko Yamada 国立研究開発法人量子科学技術研究開発機構, 量子生命科学領域, グループリーダー(定常) (50557444)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
• Keywords: Positive illusion / Cognitive bias / Gait / Depression / EEG / 認知神経科学 / 認知科学

Outline of Final Research Achievements

Using item response theory, we have estimated the optimistic prediction of future event to develop a quantitative measure of positive thinking. We then performed the correlation analysis and found that the estimated optimistic prediction was significantly correlated with BHS and BDI-II which indicated the validity of the scale.
Relationship between gait and positive thinking: Analysis of motion capture data during spontaneous walking revealed that participants who walked with large head-pelvis tilts (bending forward) estimated the likelihood of a negative event to be high.
Relationship between gait and brain activity: Analysis of frontal α asymmetry (FAA) during walking revealed that the gait control shifted FAA to the right dominant and increased the optimistic future prediction.

Academic Significance and Societal Importance of the Research Achievements

本研究によって、前向き思考と姿勢制御の関係が脳機能を介して解明されることで、こころの健康を支える身体―思考―脳機能相互作用機序の理解が深まり、うつ病患者や運動障害を呈するパーキンソン病などの病態メカニズム解明や、歩様をターゲットとした新たな非薬物治療戦略開発など、医学研究への発展が期待される。

Research Products

• [Journal Article] Primary functional brain connections associated with melancholic major depressive disorder and modulation by antidepressants (2020)
  • Author(s): Ichikawa Naho、Lisi Giuseppe、Yahata Noriaki、Okada Go、Takamura Masahiro、Hashimoto Ryu-ichiro、Yamada Takashi、Yamada Makiko、Suhara Tetsuya、Moriguchi Sho、Mimura Masaru、Yoshihara Yujiro、Takahashi Hidehiko、Kasai Kiyoto、Kato Nobumasa、Yamawaki Shigeto、Seymour Ben、Kawato Mitsuo、Morimoto Jun、Okamoto Yasumasa
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 3542-3542
  • DOI: 10.1038/s41598-020-60527-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhancing multi-center generalization of machine learning-based depression diagnosis from resting-state fMRI (2020)
  • Author(s): Nakano T, Takamura M, Ichikawa N, Okada G, Okamoto Y, Yamada M, Suhara T, Yamawaki S, Yoshimoto J
  • Journal Title: Front Psychiatry Volume: 11 Pages: 400-400
  • Peer Reviewed
• [Journal Article] 抑うつの認知バイアスの定量評価と脳イメージング (2019)
  • Author(s): 西村 春輝, 山田真希子
  • Journal Title: 医学のあゆみ Volume: 270 Pages: 795-800
• [Journal Article] Correction of head movement by frame-to-frame image realignment for receptor imaging in positron emission tomography studies with [11C]raclopride and [11C]FLB 457 (2019)
  • Author(s): Ikoma Yoko、Kimura Yasuyuki、Yamada Makiko、Obata Takayuki、Ito Hiroshi、Suhara Tetsuya
  • Journal Title: Annals of Nuclear Medicine Volume: 33 Issue: 12 Pages: 916-929
  • DOI: 10.1007/s12149-019-01405-1
  • Peer Reviewed
• [Journal Article] Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans (2018)
  • Author(s): Ito Takehito、Kimura Yasuyuki、Seki Chie、Ichise Masanori、Yokokawa Keita、Kawamura Kazunori、Takahashi Hidehiko、Higuchi Makoto、Zhang Ming-Rong、Suhara Tetsuya、Yamada Makiko
  • Journal Title: EJNMMI Research Volume: 8 Issue: 1 Pages: 48-48
  • DOI: 10.1186/s13550-018-0406-4
  • Peer Reviewed
• [Journal Article] Neuromolecular basis of faded perception associated with unreality experience (2018)
  • Author(s): Yokokawa Keita、Ito Takehito、Takahata Keisuke、Takano Harumasa、Kimura Yasuyuki、Ichise Masanori、Ikoma Yoko、Isato Ayako、Zhang Ming-Rong、Kawamura Kazunori、Ito Hiroshi、Takahashi Hidehiko、Suhara Tetsuya、Yamada Makiko
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 8062-8062
  • DOI: 10.1038/s41598-018-26382-9
  • NAID: 120006551755
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of Internal Attention to Positive and Negative Representations in Dysphoria (2018)
  • Author(s): Isato Ayako、Nishimura Haruki、Yamada Makiko、Mochizuki Satoshi
  • Journal Title: Japanese Psychological Research Volume: 60 Issue: 3 Pages: 143-155
  • DOI: 10.1111/jpr.12191
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 省察という意味での自己意識 (2018)
  • Author(s): 山田真希子
  • Journal Title: 人工知能 Volume: 33 Pages: 472-475
  • NAID: 130007917485
• [Journal Article] 社会性と脳 痛みの共感と向社会行動 (2018)
  • Author(s): 山田真希子
  • Journal Title: 生体の科学 Volume: 69(1) Pages: 59-62
• [Journal Article] うつ病の脳メカニズムはどこまで解ったか―最新脳画像研究から―4.うつ病症候に関わる認知バイアスの脳機能ネットワークと神経伝達 (2017)
  • Author(s): 山田真希子, 須原哲也
  • Journal Title: 日本生物学的精神医学会誌 Volume: 28(4) Pages: 191-195
• [Journal Article] Anatomical relationships between serotonin 5-HT2A and dopamine D2 receptors in living human brain. (2017)
  • Author(s): Ishii T, Kimura Y, Ichise M, Takahata K, Kitamura S, Moriguchi S, Kubota M, Zhang MR, Yamada M, Higuchi M, Okubo Y, Suhara T.
  • Journal Title: PLoS One. Volume: 12 Issue: 12 Pages: e0189318-e0189318
  • DOI: 10.1371/journal.pone.0189318
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Indications of success: Strategies for utilizing neuroimaging biomarkers in CNS drug discovery and development: CINP/JSNP working group report. (2017)
  • Author(s): Suhara T, Chaki S, Kimura H, Furusawa M, Matsumoto M, Ogura H, Negishi T, Saijo T, Higuchi M, Omura T, Watanabe R, Miyoshi S, Nakatani N, Yamamoto N, Liou SY, Takado Y, Maeda J, Okamoto Y, Okubo Y, Yamada M, Ito H, Walton NM, et al.
  • Journal Title: Int J Neuropsychopharmacol. Volume: 20(4) Pages: 285-294
  • DOI: 10.1093/ijnp/pyw111
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 自己価値の潜在優位性と関連する安静時脳機能ネットワーク (2019)
  • Author(s): 西村春輝, 伊里綾子, 須原哲也, 山田真希子
  • Organizer: 日本心理学会大会第83回
• [Presentation] fMRI とPET を用いた認知機能の分子・神経基盤研究 ―認知機能、脳機能、分子機能の統合的理解― (2019)
  • Author(s): 山田真希子
  • Organizer: ヒト脳イメージング研究会
• [Presentation] Quantum cognitive classification of individual differences in dopamine (2019)
  • Author(s): Yoshiharu Tanaka, Masanari Asano, Makiko Yamada
  • Organizer: The QBIC Worksho
• [Presentation] 脳イメージングが映し出す心の世界 (2019)
  • Author(s): 山田真希子
  • Organizer: 北海道大学人間知・脳・AI 研究教育センター 開所式
• [Presentation] 主観的経験の可視化 (2019)
  • Author(s): 山田真希子
  • Organizer: 日本精神神経学会
• [Presentation] 自己意識に関する認知神経科学研究 (2019)
  • Author(s): 山田真希子
  • Organizer: 「アイデンティティの内的多元性：哲学と経験科学の協同による実証研究の展開」プロジェクトのシンポジウム
  • Invited
• [Presentation] Roles of noradrenaline in neurocognitive function (2018)
  • Author(s): Makiko Yamada
  • Organizer: Neuro2018
  • Invited
• [Presentation] 自己意識と視覚の共通性： 歪んだ自己像、歪んだ世界像 (2018)
  • Author(s): 山田真希子
  • Organizer: 日本視覚学会
  • Invited
• [Presentation] 脳イメージングを用いた精神症状と認知機能の理解 (2018)
  • Author(s): 山田真希子
  • Organizer: 発達障害研究所公開セミナー2018
  • Invited
• [Presentation] 脳イメージング技術と認知バイアスに着目したうつ病診断技術の開発 (2018)
  • Author(s): 山田真希子
  • Organizer: 日本精神神経学会
  • Invited
• [Presentation] Self-awareness in relation to others and its neurocognitive basis. (2018)
  • Author(s): Makiko Yamada
  • Organizer: Inserm JSPS 二国間セミナー
  • Invited
• [Presentation] The emergence of positive illusion: integrating from molecules to neural responses, to the self. (2017)
  • Author(s): Makiko Yamada
  • Organizer: Meeting of The Australian Neuroscience Society 37TH Annual Scientific Meeting
  • Int'l Joint Research / Invited
• [Presentation] The dopamine system in subjective reality of the self and the environment. (2017)
  • Author(s): Makiko Yamada
  • Organizer: The 44th Naito Conference
  • Int'l Joint Research / Invited
• [Presentation] ポジティブ錯覚 (2017)
  • Author(s): 山田真希子
  • Organizer: 世界脳週間イベント
  • Invited
• [Presentation] ポジティブ思考の脳科学 (2017)
  • Author(s): 山田真希子
  • Organizer: 市民公開講座「脳科学の達人2017」
  • Invited
• [Presentation] 量子論的認知システムから見た心の生成原理解明へのアプローチ. (2017)
  • Author(s): 山田真希子
  • Organizer: 科学基礎論学会
  • Invited