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Dysregulation of lysosome/mitochondrial interaction in obese adipose tissue

Research Project

Project/Area Number 17H02179
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionTokyo University of Science

Principal Investigator

Higami Yoshikazu  東京理科大学, 薬学部生命創薬科学科, 教授 (90253640)

Co-Investigator(Kenkyū-buntansha) 小林 正樹  東京理科大学, 薬学部生命創薬科学科, 助教 (30795612)
中川 嘉  筑波大学, 国際統合睡眠医科学研究機構, 准教授 (80361351)
沖田 直之  山陽小野田市立山口東京理科大学, 薬学部, 講師 (60453841)
野口 満  佐賀大学, 医学部, 教授 (00325648)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2018: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords肥満症 / カロリー制限 / 脂肪組織 / ミトコンドリア生合成 / ミトファジー / PARIS / ミトコンドリア / リソソーム / ミトコンドリアシグナルペプチダーゼ / 体内時計 / スプライシング / 脂肪細胞
Outline of Final Research Achievements

Both PARKIN and PINK1, which are involved in the onset of hereditary Parkinson's disease via mitophagy defect, interact with and PARIS. We found that these proteins highly expressed in white adipose tissue (WAT). It has also been reported that PARIS binds to the Pgc-1α promoter, which is a major transcriptional cofactor involved in mitochondrial biosynthesis, negatively regulates its expression. We have shown that the expression of PARIS is increased in obese WAT, decreased by caloric restriction showing antiaging and prolongevity effects. Moreover, mitochondrial biosynthesis was reduced in PARIS overexpressing adipocytes. Therefore, our observation suggested that PARIS might be a balance regulator between mitochondrial biosynthesis and clearance in WAT.

Academic Significance and Societal Importance of the Research Achievements

肥満症やそれにともなって発症する生活習慣病の発症予防は、超高齢化社会を迎える本邦においてはもっとも重要かつ喫緊の課題である。我々の研究成果はミトコンドリアの質の改善を介する脂肪組織の質の向上、ひいては肥満症における代謝改善、生活習慣病の予防、さらに心筋梗塞や脳血管障害の予防に通ずる、貴重な研究成果であると考えられる。

Report

(4 results)
  • 2020 Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (50 results)

All 2020 2019 2018 2017 Other

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 16 results,  Open Access: 16 results) Presentation (29 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction2020

    • Author(s)
      Kobayashi M, Higami Y.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 140 Issue: 3 Pages: 383-389

    • DOI

      10.1248/yakushi.19-00193-2

    • NAID

      130007803984

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2020-03-01
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Multidisciplinary Approach to Aging: Future Trends2020

    • Author(s)
      Takahashi R, Higami Y.
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 140 Issue: 3 Pages: 377-378

    • DOI

      10.1248/yakushi.19-00193-F

    • NAID

      130007803982

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2020-03-01
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes2020

    • Author(s)
      Mizunoe Yuhei、Kobayashi Masaki、Hoshino Shunsuke、Tagawa Ryoma、Itagawa Rei、Hoshino Ayana、Okita Naoyuki、Sudo Yuka、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 634-634

    • DOI

      10.1038/s41598-020-57428-6

    • NAID

      120007165462

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism2020

    • Author(s)
      Hoshino Shunsuke、Kobayashi Masaki、Tagawa Ryoma、Konno Ryutaro、Abe Takuro、Furuya Kazuhiro、Miura Kumi、Wakasawa Hiroki、Okita Naoyuki、Sudo Yuka、Mizunoe Yuhei、Nakagawa Yoshimi、Nakamura Takeshi、Kawabe Hiroshi、Higami Yoshikazu
    • Journal Title

      FEBS Open Bio

      Volume: 10 Issue: 3 Pages: 306-315

    • DOI

      10.1002/2211-5463.12795

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome2019

    • Author(s)
      Mizunoe Yuhei、Kobayashi Masaki、Tagawa Ryoma、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 15 Pages: 3688-3688

    • DOI

      10.3390/ijms20153688

    • NAID

      120007133171

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.2019

    • Author(s)
      Namiki Fujii, Seira Uta, Masaki Kobayashi, Tsugumichi Sato, Naoyuki Okita, Yoshikazu Higami
    • Journal Title

      Experimental gerontology

      Volume: 118 Pages: 55-64

    • DOI

      10.1016/j.exger.2019.01.001

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes2019

    • Author(s)
      Kobayashi Masaki、Hoshino Shunsuke、Abe Takuro、Okita Naoyuki、Tagawa Ryoma、Nagai Wataru、Konno Ryutaro、Suzuki Yuki、Furuya Kazuhiro、Ishikawa Natsumi、Okado Hitoshi、Oku Misako、Iwamoto Machiko、Miura Yuri、Sudo Yuka、Higami Yoshikazu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 508 Issue: 1 Pages: 117-122

    • DOI

      10.1016/j.bbrc.2018.11.127

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways2018

    • Author(s)
      Mizunoe Yuhei、Kobayashi Masaki、Sudo Yuka、Watanabe Shukoh、Yasukawa Hiromine、Natori Daiki、Hoshino Ayana、Negishi Arisa、Okita Naoyuki、Komatsu Masaaki、Higami Yoshikazu
    • Journal Title

      Redox Biol.

      Volume: 15 Pages: 115-124

    • DOI

      10.1016/j.redox.2017.09.007

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats2018

    • Author(s)
      Narita Takumi、Kobayashi Masaki、Itakura Kaho、Itagawa Rei、Kabaya Riho、Sudo Yuka、Okita Naoyuki、Higami Yoshikazu
    • Journal Title

      Exp Gerontol

      Volume: 104 Pages: 127-137

    • DOI

      10.1016/j.exger.2018.01.016

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Taurine is an amino acid with the ability to activate autophagy in adipocytes.2018

    • Author(s)
      Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M, Higami Y
    • Journal Title

      Amino Acids

      Volume: 50 Issue: 5 Pages: 527-535

    • DOI

      10.1007/s00726-018-2550-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals.2018

    • Author(s)
      Hoshino S, Kobayashi M, Higami Y
    • Journal Title

      Aging (Albany NY)

      Volume: 10 Issue: 9 Pages: 2243-2251

    • DOI

      10.18632/aging.101557

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction.2018

    • Author(s)
      Masaki Kobayashi, Namiki Fujii, Takumi Narita, Yoshikazu Higami
    • Journal Title

      International Journal of Molecular Sciences

      Volume: - Issue: 11 Pages: 11-11

    • DOI

      10.3390/ijms19113335

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia2018

    • Author(s)
      Sudo Yuka、Otsuka Hiroki、Miyakawa Ryota、Goto Akifumi、Kashiwase Yohei、Terawaki Kiyoshi、Miyano Kanako、Hirao Yuto、Taki Kanari、Tagawa Ryoma、Kobayashi Masaki、Okita Naoyuki、Uezono Yasuhito、Higami Yoshikazu
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19 Issue: 12 Pages: 3852-3852

    • DOI

      10.3390/ijms19123852

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction2017

    • Author(s)
      Kobayashi Masaki、Takeda Kanae、Narita Takumi、Nagai Keita、Okita Naoyuki、Sudo Yuka、Miura Yuri、Tsumoto Hiroki、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
    • Journal Title

      FEBS Lett.

      Volume: 591 Issue: 24 Pages: 4067-4073

    • DOI

      10.1002/1873-3468.12914

    • NAID

      120007134579

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel caloric restriction mediator2017

    • Author(s)
      Kobayashi Masaki、Higami Yoshikazu
    • Journal Title

      Aging (Albany NY)

      Volume: 9 Issue: 10 Pages: 2012-2013

    • DOI

      10.18632/aging.101311

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction2017

    • Author(s)
      Fujii Namiki、Narita Takumi、Okita Naoyuki、Kobayashi Masaki、Furuta Yurika、Chujo Yoshikazu、Sakai Masahiro、Yamada Atsushi、Takeda Kanae、Konishi Tomokazu、Sudo Yuka、Shimokawa Isao、Higami Yoshikazu
    • Journal Title

      Aging Cell

      Volume: 16 Issue: 3 Pages: 508-517

    • DOI

      10.1111/acel.12576

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice2017

    • Author(s)
      Mizunoe Yuhei、Sudo Yuka、Okita Naoyuki、Hiraoka Hidenori、Mikami Kentaro、Narahara Tomohiro、Negishi Arisa、Yoshida Miki、Higashibata Rikako、Watanabe Shukoh、Kaneko Hiroki、Natori Daiki、Furuichi Takuma、Yasukawa Hiromine、Kobayashi Masaki、Higami Yoshikazu
    • Journal Title

      Autophagy

      Volume: 13 Issue: 4 Pages: 642-653

    • DOI

      10.1080/15548627.2016.1274850

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modified Western blotting for insulin and other diabetes-associated peptide hormones.2017

    • Author(s)
      Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
    • Journal Title

      Sci Rep

      Volume: 7:6949 Issue: 1 Pages: 1-11

    • DOI

      10.1038/s41598-017-04456-4

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] A Novel Molecular Mechanism of Metabolic Remodeling, Anti-aging and Pro-longevity Actions of Caloric Restriction2019

    • Author(s)
      Higami Y, Kobayashi M, Tagawa R
    • Organizer
      第42回日本分子生物学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 栄養とサルコペニア ~長期カロリー制限モデルからの知見を基にした考察~2019

    • Author(s)
      樋上賀一
    • Organizer
      第31回日本老年学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] カロリー制限による脂肪細胞組織での代謝リモデリング2019

    • Author(s)
      樋上賀一
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] カロリー制限による脂肪細胞におけるミトコンドリア機能亢進メカニズムの解析2019

    • Author(s)
      内田理緒、瀧加菜里、小林正樹、樋上賀一
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肥満症脂肪組織における新規肥満応答因子WWP1の機能解析2019

    • Author(s)
      若澤広樹、星野駿介、古屋和寛、三浦久実、小林正樹、樋上賀一
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] リソソーム機能異常が脂肪滴局在タンパク質ペリリピンに及ぼす影響の解析2018

    • Author(s)
      水之江雄平、樋上賀一、小林正樹、星野駿介、中川 嘉、島野 仁
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗老化・寿命延伸作用を示すカロリー制限による脂肪組織リモデリングにおける新規メディエーター2018

    • Author(s)
      樋上賀一、小林正樹
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] タウリンの生体内恒常性維持機構の解析2018

    • Author(s)
      吉田眞帆、小林正樹、井前正人、樋上賀一
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 肥満マウス脂肪組織における新規肥満応答因子Wwp1の機能解析2018

    • Author(s)
      星野駿介、小林正樹、樋上賀一
    • Organizer
      第39回日本肥満学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Influence of WWP1 on antioxidant function in obese adipose tissue2018

    • Author(s)
      Kazuhiro FURUYA, Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] A novel mitochondoria activation mechanism in adipocytes by caloric restriction2018

    • Author(s)
      Knari TAKI, Masaki KOBAYASI, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] The mechanisms of lysosomal dysfunction in white adipose tissue of short-term high-fat diet model2018

    • Author(s)
      Natsumi MIZUSHIMA, Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Functional analysis of E3 ubiquitin ligase Wwp1 in mouse white adipose tissue2018

    • Author(s)
      Shunsuke HOSHINO, Msaki KOBAYASI, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] The effect of decreasing activity of cathepsin L on adipocytes2018

    • Author(s)
      Misako SAKURAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Transcriptional regulation of Fgf21 and Pgc-1 α by caloric restriction2018

    • Author(s)
      Seira UTA, Namiki FUJII, Masaki KOBAYASH, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Tarurin is an amino acid with the ability to activate autophagy in adipocytes2018

    • Author(s)
      Masaki KOBAYASHI, Hiroki KANEKO, Yuhei MIZUNOE, Maho YOSHIDA, Masato IMAE, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Effects of aging and caloric restriction in Wwp1 expression in skletal muscle2018

    • Author(s)
      Kumi MIURA, Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Analysis of pharmacological relationship between a Japanese Kanpo Kamikihito on oxytocin receptors2018

    • Author(s)
      Yuki YOSHIDA, Kanako MIYANO, Yuji OMIYA, Yoshikazu HIGAMI, Yasuhito UEZONO
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
  • [Presentation] Novel mediators for caloric restriction -associated metabolic remodeling in white adipose tissue2018

    • Author(s)
      Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 小林正樹、樋上賀一2018

    • Author(s)
      カロリー制限による白色脂肪組織における新規ミトコンドリア活性化メカニズム
    • Organizer
      第61回日本糖尿病学会年次集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A novel mediator for pro-longevity and anti-aging actions of caloric restriction2018

    • Author(s)
      Masaki Kobayashi, Yoshikazu Higami
    • Organizer
      Asian Society for Aging Research Symposium 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 短期高脂肪食摂餌モデルの脂肪組織におけるリソソーム機能破綻メカニズムの解析2018

    • Author(s)
      古市拓真、水之江雄平、小林正樹、樋上賀一
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Obese Pathology Affected by Lysosomal Dysfunction2017

    • Author(s)
      Rei Itagawa, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami
    • Organizer
      第17回日本ミトコンドリア学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role of MIPEP in improvement of metabolism by CR2017

    • Author(s)
      Keita Nagai, Yoshikazu HIgami, Masaki Kobayashi
    • Organizer
      第17回日本ミトコンドリア学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The role mitochondrial intermediate peptidase (MIPEP) in improvement of mitochondrial metabolism by Caloric Restriction2017

    • Author(s)
      Keita NAGAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第40回日本基礎老化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of an Obesity Pathology affected by Lysosomal Dysfunction2017

    • Author(s)
      Rei ITAGAWA, Yuhei MIZUNOE, Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第40回日本基礎老化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Function analysis of obesity-induced E3 ubiquitin ligase, Wwp1, in the obese adipose tissue2017

    • Author(s)
      Shunsuke HOSHINO, Masaki KOBAYASHI, Yoshikazu HIGAMI
    • Organizer
      第40回日本基礎老化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 皮下脂肪と内臓脂肪におけるカロリー制限への応答の相違2017

    • Author(s)
      成田匠、小林正樹、須藤結香、沖田直之、樋上賀一
    • Organizer
      第38回日本肥満学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肥満症脂肪組織における新規肥満応答因子Wwp1の機能解析2017

    • Author(s)
      星野駿介、小林正樹、樋上賀一
    • Organizer
      第38回日本肥満学会
    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.tus.ac.jp/fac_grad/p/intro.php?5289

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www.rs.tus.ac.jp/tr/

    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗肥満物質のスクリーニング方法及び抗肥満物質のスクリーニング用キット2018

    • Inventor(s)
      樋上賀一、小林正樹、成田匠、瀧加菜里
    • Industrial Property Rights Holder
      樋上賀一、小林正樹、成田匠、瀧加菜里
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-133627
    • Filing Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2017-04-28   Modified: 2023-12-25  

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