Investigation on how to adjust fatty liver metabolically for suppression of diabetes
| Project/Area Number |
17H02180
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Toho University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
弘世 貴久 東邦大学, 医学部, 教授 (40384119)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 脂肪肝 / インスリン感受性 / 肝臓体積 / 非アルコール性脂肪肝 / 肝インスリン感受性 / 筋インスリン感受性 / 脂肪組織インスリン感受性 / 生活習慣病 |
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| Outline of Final Research Achievements |
We have established a new method for accurately assessing the lipid accumulation in the liver that can also be used in longitudinal studies. The MRI images (water and fat images) of the Dexon method were used to objectively determine the absolute quantification of total liver volume, total hepatic fat volume, and total hepatic lean volume. Using this method, we analyzed data from cross-sectional studies and found that hepatic lean volume rather than fat volume was significantly and negatively correlated with hepatic insulin sensitivity. This trend was more pronounced in fatty liver patients with type 2 diabetes mellitus. We are now investigating the underlying mechanisms through longitudinal studies in humans and interventional studies in mice.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果は、脂肪肝において肝インスリン感受性を保持する（脂肪との共存を実現する）ために重要な因子として、肝臓へ蓄積する脂肪ではなく、脂肪を受け止める肝臓の大きさが重要であることを初めて明らかにした、学術的に大きな意義をもつものである。今後、脂肪蓄積を減らすことが困難な高齢社会に、大きなブレークスルーをもたらす礎となる研究成果を得ることができた。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Characteristics of hepatic insulin-sensitive nonalcoholic fatty liver disease.2017
Author(s)
Shigiyama F, Kumashiro N, Furukawa Y, Funayama T, Takeno K, Wakui N, Ikehara T, Nagai H, Taka H, Fujimura T, Uchino H, Tamura Y, Watada H, Nemoto T, Shiraga N, Sumino Y, Hirose T.
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Journal Title
Hepatol Commun.
Volume: 1
Issue: 7
Pages: 634-647
DOI
Related Report
Peer Reviewed / Open Access
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