• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of preconditioning with magnetic field stimulation in the mechanoresponse of bone tissue

Research Project

Project/Area Number 17H02181
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionNational Institute of Fitness and Sports in Kanoya (2019-2020)
Niigata University of Health and Welfare (2017-2018)

Principal Investigator

TAMAKI Hiroyuki  鹿屋体育大学, スポーツ生命科学系, 教授 (40253926)

Co-Investigator(Kenkyū-buntansha) 與谷 謙吾  鹿屋体育大学, スポーツ生命科学系, 准教授 (10581142)
山本 智章  新潟医療福祉大学, その他部局等, ロコモティブ症候群予防研究センター副センター長 (30445902)
桐本 光  広島大学, 医系科学研究科(保), 教授 (40406260)
石道 峰典  大阪工業大学, 工学部, 講師 (80737536)
大西 秀明  新潟医療福祉大学, リハビリテーション学部, 教授 (90339953)
Project Period (FY) 2017-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords骨組織 / メカニカルストレス / 磁場刺激 / 骨 / 強度 / 磁場 / 筋収縮
Outline of Final Research Achievements

Muscle contraction force is one of the significant factors that drives beneficial mechanical stress on bone in vivo. Bone mechanosensitivity tends to decrease with aging and disuse. We investigated the effects of preconditioning with static and pulsed magnetic field stimulation prior to the intervention of repetitive mechanical stimulation on reduction in disuse-induced bone loss in order to improve the effects of mechanical stimulation on bone tissue in aged rats. Intervention of magnetic stimulation alone did not improve the disuse-induced bone loss and deterioration of trabecular bone architecture. Preconditioning with magnetic field stimulation prior to the intervention of mechanical stimulation promoted the reduction effects of disuse-induced bone loss in aged rats in dependent on the intensity of magnetic field stimulation. The results suggest that the preconditioning with magnetic field stimulation on bone tissue have an effect on changing the mechanoreactivity.

Academic Significance and Societal Importance of the Research Achievements

本研究では、不動による骨量低下や骨組織の構造破壊の改善にプレコンディショニング磁場刺激が条件依存的に高齢期においてもポジティブに機能することを示す結果を得た。不動期間の長さにより骨への運動刺激効果が現れにくくなる問題に関して、プレコンディショニング磁場刺激が機械的刺激への反応性を調整するツールとして、運動処方プログラムの開発等に貢献する可能性がある。特に、骨ひずみを得にくい高齢期の骨の力学的感度の改善に意義を有する。

Report

(5 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (15 results)

All 2020 2019 2018 2017

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (9 results) (of which Int'l Joint Research: 4 results) Book (1 results)

  • [Journal Article] Myofiber permeability and force production of rat muscles following eccentric contractions: The repeated bout effect depends on the interval.2020

    • Author(s)
      Hayao K, Tamaki H, Tamakoshi K, Takahashi H, Onishi H
    • Journal Title

      Journal of Biomedical Science and Engineering

      Volume: 13 Issue: 12 Pages: 106270-106270

    • DOI

      10.4236/jbise.2020.1312025

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low-frequency electrical stimulation of denervated skeletal muscle retards muscle and trabecular bone loss in aged rats.2019

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Hayao K, Kirimoto H, Onishi H, Kasuga N, Yamamoto N,
    • Journal Title

      International Journal of Medical Sciences

      Volume: 印刷中 Issue: 6 Pages: 822-830

    • DOI

      10.7150/ijms.32590

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Low-frequency electrical stimulation of denervated skeletal muscle retards muscle and trabecular bone loss in aged rats.2019

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Hayao K, Kirimoto H, Onishi H, Kasuga N, Yamamoto N,
    • Journal Title

      International Journal of Medical Sciences

      Volume: 印刷中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of streptomycin administration on increases in skeletal muscle fiber permeability and size following eccentric muscle contractions.2018

    • Author(s)
      Hayao K., Tamaki H., Nakagawa K., Tamakoshi K., Takahashi H., Yotani K., Ogita F., Yamamoto N., Onishi H.
    • Journal Title

      Anat. Rec.

      Volume: 301 Issue: 6 Pages: 1096-1102

    • DOI

      10.1002/ar.23770

    • Related Report
      2018 Annual Research Report 2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transcranial Static Magnetic Field Stimulation over the Primary Motor Cortex Induces Plastic Changes in Cortical Nociceptive Processing2018

    • Author(s)
      Kirimoto Hikari、Tamaki Hiroyuki、Otsuru Naufumi、Yamashiro Koya、Onishi Hideaki、Nojima Ippei、Oliviero Antonio
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 12 Pages: 63-63

    • DOI

      10.3389/fnhum.2018.00063

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Effects of bone strain of rat tibia during electrical stimulation-induced muscle contraction on bone strength in the early stages of disuse musculoskeletal atrophy.2020

    • Author(s)
      Tamaki H, Yotani K, Ogita F
    • Organizer
      2020 Annual Meeting of American Society for Bone and Mineral Research
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of different type of muscle contraction induced by electrical stimulation on in vivo bone strain of rat tibia.2020

    • Author(s)
      Tamaki H, Yotani K, Ogita F
    • Organizer
      Journal of Physical Fitness and Sports Medicine
    • Related Report
      2020 Annual Research Report
  • [Presentation] Characterization of in vivo bone strain of rat tibia during electrical stimulation-induced muscle contraction2019

    • Author(s)
      Tamaki H, Yotani K, Hayao K, Ogita F,
    • Organizer
      Journal of Physical Fitness and Sports Medicine
    • Related Report
      2019 Annual Research Report
  • [Presentation] In vivo strain environment and effective strain rate of rat tibia during low-frequency electrical stimulation-induced muscle contraction for reduction of disuse bone loss.2019

    • Author(s)
      Tamaki H, Yotani K, Ogita F
    • Organizer
      Adv Exerc Sports Physiol
    • Related Report
      2019 Annual Research Report
  • [Presentation] Repeated bout effect on myofiber permeability and muscle function that is dependent on the intervals between initial and second bouts of eccentric contractions in rat skeletal muscle.2019

    • Author(s)
      Hayao K, Tamaki H, Nakagawa K, Yotani K, Ogita F, Tamakoshi K, Takahashi H, Onishi H, Yamamoto N,
    • Organizer
      24th Annual Congress of European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 刺激強度及び距離の異なる磁場刺激による骨内磁場強度の変化特性.2018

    • Author(s)
      田巻弘之,與谷謙吾,荻田 太,早尾啓志,桐本 光,大西秀明,山本智章,春日規克,
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 筋線維膜透過性亢進及び筋収縮張力に対する伸張性収縮の反復効果.2018

    • Author(s)
      早尾啓志,田巻弘之,中川弘毅,與谷謙吾,荻田 太,玉越啓悟,高橋英明,山本智章,大西秀明,
    • Organizer
      第53回日本理学療法学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Streptomycin attenuates the effects of electrical stimulation-induced muscle contraction on reducing trabecular bone loss in the early stages of disuse in old rats.2017

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Hayao K, Tamakoshi K, TakahashiH, Tsubaki A, Kirimoto H, Onishi H, Kasuga N, Yamamoto N,
    • Organizer
      2017 Annual Meeting of American Society for Bone and Mineral Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of repeated bouts on sarcolemmal permeability and muscle force production after eccentric contractions in rat skeletal muscle.2017

    • Author(s)
      Hayao K, Tamaki H, Nakagawa K,Yotani K, Ogita F, Yamamoto N, Kasuga N, Onishi H,
    • Organizer
      2nd Annual Congress of European College of Sport Science
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 運動生理学の基礎と発展3訂版2018

    • Author(s)
      春日規克, 田巻弘之
    • Total Pages
      277
    • Publisher
      フリースペース
    • ISBN
      9784434250231
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi