| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
The mortality from ischemic heart disease is much lower in Japan than in Western countries. In order to elucidate the reason for this difference, expression levels of microRNAs in the blood were totally analyzed and compared in Austrians and Japanese. The levels of 372 miRNAs showed significant difference between the countries, and the targeting molecules of these miRNAs were suggested to be collagen in vascular smooth muscle cells and IL-1, IL-6, IL-8, TNF, MMP-3 and MMP-9 in foam cells. There were 12 miRNAs that showed significant difference in their expression levels in the blood of Austrian and Japanese men and were reported to be associated with ischemic heart disease.
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