Roles of neural metabolic signaling pathway in transitional mechanism to AD
| Project/Area Number |
17H02188
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
Akiko Taguchi 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 部長 (80517186)
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| Co-Investigator(Kenkyū-buntansha) |
福井 裕介 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 研究員 (60824802)
田之頭 大輔 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 研究員 (80724575)
王 蔚 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 研究員 (00845167)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2017: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 糖尿病 / 糖代謝調節 / 脳 / 認知機能 / 加齢 / 糖代謝調節経路 / アルツハイマー病 / 脳代謝調節経路 / 認知機能障害 / インスリンシグナル / 認知症 / 栄養 / 運動 / 痴呆 / 老化 / 脳神経疾患 / トランスレーショナルリサーチ |
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| Outline of Final Research Achievements |
We found that1) type2 diabetes (T2DM)-induced memory decline accompanied by alterations in glucose metabolism-related signaling components in the hippocampus is provoked by an amyloid beta (Aβ)-independent mechanism, 2) type1 diabetes (T1DM)-induced memory deficit arises independently of the modification of glucose metabolism-related signaling factors and independently of Aβ, 3) hippocampal alterations in glucose metabolism-related signaling occur when middle-aged novel AD model mice show cognitive decline, 4) T2DM additively exacerbates cognitive impairment and alterations in hippocampal glucose metabolism-related signaling in middle-aged novel AD model mice, and 5) aged mice that have normal glucose metabolism display Aβ-unrelated memory impairment accompanied by alterations in hippocampal glucose metabolism-related signaling as well as T2DM model mice show.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、脳の糖代謝調節経路とAβ非依存的認知機能低下の関係および同経路とAβの関係を明らかにした点で学術的意義が深い。これらの詳細なメカニズムについての今後の検討により、認知機能障害の新たな予防・治療法の開発に貢献する可能性がある。
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Report
(3 results)
Research Products
(31 results)
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[Journal Article] Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain.2018
Author(s)
Shang J, Yan H, Jiao Y, Ohta Y, Liu X, Li X, Morihara R, Nakano Y, Fukui Y, Shi X, Huang Y, Feng T, Takemoto M, Sato K, Hishikawa N, Yamashita T, Abe K.
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 27(8)
Pages: 2096-2105
DOI
Related Report
Peer Reviewed
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[Journal Article] A Unique Case with Oral Dyskinesia, Chorea, Ataxia, and Mild Cognitive Impairment with Caudate Atrophy and Characteristic Brain Calcifications2018
Author(s)
Hishikawa N, Fukui Y, Sato K, Takemoto M, Yamashita T, Ohta Y, Abe K.
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Journal Title
Intern. Med.
Volume: 57(16)
Issue: 16
Pages: 2399-2402
DOI
NAID
ISSN
0918-2918, 1349-7235
Related Report
Peer Reviewed
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[Journal Article] Neuroprotective Effects of Tocovid Pretreatment in a Mouse Stroke Model2018
Author(s)
Jiao Y, Shang J, Ohta Y, Yan H, Liu X, Li X, Morihara R, Nakano Y, Fukui Y, Shi X, Huang Y, Feng T, Takemoto M, Sato K, Hishikawa N, Yamashita T, Abe K
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 27(8)
Pages: 2166-2174
DOI
Related Report
Peer Reviewed
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[Journal Article] Antineuroinflammatory Effect of SMTP-7 in Ischemic Mice2018
Author(s)
Huang Y, Ohta Y, Shang J, Morihara R, Nakano Y, Fukui Y, Liu X, Shi X, Feng T, Yamashita T, Sato K, Takemoto M, Hishikawa N, Suzuki E, Hasumi K, Abe K
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 27(11)
Pages: 3084-3094
Related Report
Peer Reviewed
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[Journal Article] Neuroprotective effects of SMTP-44D in mice stroke model in relation to neurovascular unit and trophic coupling2018
Author(s)
Shi X, Ohta Y, Shang J, Morihara R, Nakano Y, Fukui Y, Liu X, Feng T, Huang Y, Sato K, Takemoto M, Hishikawa N, Yamashita T, Suzuki E, Hasumi K, Abe K
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Journal Title
J Neurosci Res.
Volume: 96(12)
Pages: 1887-1899
DOI
Related Report
Peer Reviewed
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