Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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Outline of Final Research Achievements |
AIM has been attracting attention as a drug candidate for renal failure in cats. In this research, we performed chemical investigation on the molecular mechanism of AIM and revealed that one of the various biological functions of AIM is the inhibitory action to the generation of reactive oxygen species (ROS) by free iron. Furthermore, based on the molecular structure of AIM, we designed and synthesized a peptide with a molecular weight of about 1200 and a low molecule with a molecular weight of about 500, which possess inhibitory effect on the generation of ROS by free iron.
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