| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Astrocytes were thought as passive support cells, bringing nutrients to and removing wastes form the neurons. Recent studies challenged this view and demonstrated that astrocyte plays a critical role in information processing in the brain. However, it is unclear how astrocyte is involved in higher brain functions. In this study, we focused on the basal ganglia and identified specific marker genes of striatal astrocytes that are associated with direct and indirect pathways. The combination of these marker genes and genome editing techniques will accelerate the elucidation of circuit-specific functions of astrocytes.
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