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Circuit-specific neuron-astrocyte cross-talk in the striatum

Research Project

Project/Area Number 17H02216
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic / Social brain science
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Tanaka Kohichi  東京医科歯科大学, 難治疾患研究所, 教授 (80171750)

Project Period (FY) 2017-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywordsアストロサイト / 線条体 / 直接路 / 間接路 / ゲノム編集
Outline of Final Research Achievements

Astrocytes were thought as passive support cells, bringing nutrients to and removing wastes form the neurons. Recent studies challenged this view and demonstrated that astrocyte plays a critical role in information processing in the brain. However, it is unclear how astrocyte is involved in higher brain functions. In this study, we focused on the basal ganglia and identified specific marker genes of striatal astrocytes that are associated with direct and indirect pathways. The combination of these marker genes and genome editing techniques will accelerate the elucidation of circuit-specific functions of astrocytes.

Academic Significance and Societal Importance of the Research Achievements

本研究により、アストロサイトの各サブタイプが特定の神経回路において果たす役割の解明が促進され、アストロサイトの機能制御による脳機能制御という新しい研究分野を開拓できる。さらに、本研究は、アストロサイトの異常が示唆されているハンチントン病・アルツハイマー病・パーキンソン病・筋萎縮性側索硬化症などの神経変性疾患やうつ病・自閉症・統合失調症などの精神疾患の病態解明及び新規治療薬の開発に貢献すると期待される。

Report

(4 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (16 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (5 results) Journal Article (10 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 10 results,  Open Access: 6 results) Remarks (1 results)

  • [Int'l Joint Research] The University of Edinburgh/Heriot-Watt University(英国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Johns Hopkins University(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Institute for stem cell biology(インド)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Karolinska Institute(スウェーデン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] University of Zurich/Institute of Pharmacology and Toxicology(スイス)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Establishment of a tTA-dependent photoactiveatable Cre recombinease knock-in mouse model for optogenetic genome engineering.2020

    • Author(s)
      9.Takao, T., Hiraoka, Y., Kawabe, K., Yamada, D., Ming, L., Tanaka, K., Sato, M., Takarada, T.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 526 Issue: 1 Pages: 213-217

    • DOI

      10.1016/j.bbrc.2020.03.015

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional roles of glial glutamate transporter (GLAST) in emotional and cognitive abnormalities of mice after repeated phencyclidine administration.2019

    • Author(s)
      chida, M., Hida, H., Mori, K., Yoshimi, A., Kitagaki, S., Yamada, K., Hiraoka, Y., Aida, T., Tanaka, K., Ozaki, N., Noda, Y.
    • Journal Title

      European Neuropsychopharmacology

      Volume: 29 Issue: 8 Pages: 914-924

    • DOI

      10.1016/j.euroneuro.2019.06.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biased genome editing using the local accumulation of DSB repair molecules system.2018

    • Author(s)
      Nakade S, Mochida K, Kunii A, Nakamae K, Aida T, Tanaka K, Sakamoto N, Sakuma T, Yamamoto T
    • Journal Title

      Nature Communications

      Volume: 9(1) Issue: 1 Pages: 3270-3270

    • DOI

      10.1038/s41467-018-05773-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells2018

    • Author(s)
      Perkins Emma M、Clarkson Yvonne L、Suminaite Daumante、Lyndon Alastair R、Tanaka Kohichi、Rothstein Jeffrey D、Skehel Paul A、Wyllie David J A、Jackson Mandy
    • Journal Title

      Human Molecular Genetics

      Volume: 27 Issue: 15 Pages: 2614-2627

    • DOI

      10.1093/hmg/ddy169

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Region-specific deletions of the glutamate transporter GLT1 differentially affect nerve injury-induced neuropathic pain in mice2018

    • Author(s)
      Zhao Zhuoyang、Hiraoka Yuichi、Ogawa Hiroshi、Tanaka Kohichi
    • Journal Title

      Glia

      Volume: 66 Issue: 9 Pages: 1988-1998

    • DOI

      10.1002/glia.23452

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth2018

    • Author(s)
      Reichenbach Bettina、Classon Johanna、Aida Tomomi、Tanaka Kohichi、Genander Maria、G?ritz Christian
    • Journal Title

      The EMBO Journal

      Volume: 37 Issue: 9

    • DOI

      10.15252/embj.201798280

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Spinal cord-specific deletion of the glutamate transporter GLT1 causes motor neuron death in mice2018

    • Author(s)
      Sugiyama Kaori、Tanaka Kohichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 497 Issue: 2 Pages: 689-693

    • DOI

      10.1016/j.bbrc.2018.02.132

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice2017

    • Author(s)
      Sugimoto Junya、Tanaka Moeko、Sugiyama Kaori、Ito Yukiko、Aizawa Hidenori、Soma Miho、Shimizu Tomoko、Mitani Akira、Tanaka Kohichi
    • Journal Title

      Glia

      Volume: 66 Issue: 4 Pages: 777-788

    • DOI

      10.1002/glia.23281

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calpain-Dependent Degradation of Nucleoporins Contributes to Motor Neuron Death in a Mouse Model of Chronic Excitotoxicity2017

    • Author(s)
      Sugiyama Kaori、Aida Tomomi、Nomura Masatoshi、Takayanagi Ryoichi、Zeilhofer Hanns U.、Tanaka Kohichi
    • Journal Title

      The Journal of Neuroscience

      Volume: 37 Issue: 36 Pages: 8830-8844

    • DOI

      10.1523/jneurosci.0730-17.2017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Glutamate transporter GLAST controls synaptic wrapping by Bergmann glia and ensures proper wiring of Purkinje cells2017

    • Author(s)
      Miyazaki T, Yamasaki M, Hashimoto K, Kohda K, Yuzaki M, Shimamoto K, Tanaka K, Kano M, Watanabe M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 114 Issue: 28 Pages: 7438

    • DOI

      10.1073/pnas.1617330114

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] 分子神経科学分野

    • URL

      http://www.tmd.ac.jp/mri/aud/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2017-04-28   Modified: 2021-02-19  

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