| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2018: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2017: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Arc-dVenus mouse is a transgenic mouse line that expresses fluorescent protein in activated neurons. By using this mouse line, we analyzed the distribution patterns of the hippocampal dentate granule cells activated by various stimuli. We found that the distribution patterns of the activated neurons are stimulus specific and the pattern formation processes are mainly dominated by genetic factors. Moreover, we found that the activation patterns of neurons in the specific cortical areas are dysregulated in the mouse models harboring autism and schizophrenia-associated mutations.
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