Experience-induced hippocampal asymmetry in rodents

• Project/Area Number: 17H02221
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Jichi Medical University (2019-2020); Nagoya City University (2017-2018)
• Principal Investigator: Shinohar Yoshiaki 自治医科大学, 医学部, 教授 (10425423)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2018: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 海馬 / 生後環境 / 左右差 / 経験 / 可塑的変化 / 動物の環境 / 脳 / 解剖学 / 生理学 / 神経生理学 / 脳の左右差 / 豊かな環境

Outline of Final Research Achievements

We integrate our results of this research propose with KAKENHI 20H03295, which aims to investigate the cortico-hippocampal interactions modulated by postnatal stimuli. The reasons are as follows. 1) The comparisons between cortico-hippocampal and bilateral hippocampal interactions have greater scientific significance 2) The interactions between the cortex and hippocampus could cause left-right asymmetry of hippocampal functions. So, we submitted our results of cortico-hippocampal integration in bioRxiv, and now trying to publish the results. Then, we are seeking to publish our result of bilateral hippocampal asymmetry.

Academic Significance and Societal Importance of the Research Achievements

脳の左右差や生後の育った環境による脳の変化は、ともに神経科学の研究者のみではなく、一般の方の興味を惹くであるテーマだと考えており、事実、一般読者向けの科学雑誌に当研究の内容は掲載されたこともある。特に、幼少時の環境がその後長期間に渡って脳の発達に影響を与えるという実験的な事実は育児や社会活動などにも密接につながる。

Research Products

• [Journal Article] Perivascular macrophages produce type I collagen around cerebral small vessels under prolonged hypertension in rats (2021)
  • Author(s): Inagaki Takeshi、Fujiwara Ken、Shinohara Yoshiaki、Azuma Morio、Yamazaki Reiji、Mashima Kiyomi、Sakamoto Atsushi、Yashiro Takashi、Ohno Nobuhiko
  • Journal Title: Histochemistry and Cell Biology Volume: Published online Issue: 4 Pages: 1-10
  • DOI: 10.1007/s00418-020-01948-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization (2021)
  • Author(s): H Monai, S Koketsu, Y Shinohara, T Ueki, P Kusk, Hauglund, NL, Samson AJ, Nedergaard M, Hirase H
  • Journal Title: Sci Rep Volume: 11(1) Issue: 1 Pages: 8150-8160
  • DOI: 10.1038/s41598-021-87609-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rearing-environment-dependent hippocampal local field potential differences in wild-type and inositol trisphosphate receptor type 2 knockout mice (2017)
  • Author(s): Tanaka Mika、Wang Xiaowen、Mikoshiba Katsuhiko、Hirase Hajime、Shinohara Yoshiaki
  • Journal Title: The Journal of Physiology Volume: 595 Issue: 20 Pages: 6557-6568
  • DOI: 10.1113/jp274573
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 生後環境依存的に変化する神経細胞のシナプス及びミトコンドリアの電子顕微鏡解析 (2021)
  • Author(s): 篠原良章、大野伸彦
  • Organizer: 日本解剖学会総会
• [Presentation] Left-right asymmetry of the rodent hippocampal synapses and its implications for functional laterality of the hippocampus. (2018)
  • Author(s): Shinohara Y, Hirase H, Ueki T
  • Organizer: 日本解剖学会総会
  • Int'l Joint Research
• [Presentation] 電子顕微鏡画像データからの自動シナプス検出 (2017)
  • Author(s): 篠原良章 植木孝俊
  • Organizer: 日本解剖学会中部支部学術集会
• [Remarks] 自治医科大学医学部解剖学組織学部門
  • URL: https://www.jichi.ac.jp/histology/