Opto-Electric Brain Machine Interface using Flexible-CMOS Hybrid Technology

• Project/Area Number: 17H02222
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Brain biometrics
• Research Institution: Tokyo Institute of Technology (2019-2020); Nara Institute of Science and Technology (2017-2018)
• Principal Investigator: Tokuda Takashi 東京工業大学, 科学技術創成研究院, 教授 (50314539)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000); Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2018: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
• Keywords: ブレイン・マシン・インターフェース / BMI / CMOS / オプトジェネティクス / バイオチップ / バイオエレクトロニクス / 光刺激

Outline of Final Research Achievements

An opto-electric brain machine interface based on the planned concept was successfully developed. The device has following features:
1, The device has a structure consisgting of multiple unit devices connected with flexible bridge structure. The strcuture can be bent two-dimensionally. 2. Each unit device is equipped with dedicated CMOS control chip. The chip can be used as a selector for multiple LED or neural electrodes on each unit device. 3. Each CMOS chip on the unit device has its unique ID and identification sequence. So multiple CMOS chip connnected on shared bus wirings (5-6 wires) can be consistently operated.

Academic Significance and Societal Importance of the Research Achievements

本研究により、CMOS集積回路の高機能性・多チャンネルスイッチング性を利用しながら、広い範囲で、かつ2次元屈曲可能なブレイン・マシン・インターフェース(BMI)の有効な形態を提示することができた。今後、本研究で開発した技術を新たなデバイス開発に有効利用することができる。特に光と電気を両方用いるというコンセプトは、今世紀に入って大きく発展した光遺伝学(オプトジェネティクス)を取り込んだBMI技術のニーズにこたえることができると期待する。

Research Products

• [Journal Article] Optical Powering Platform for Ultra-Small Implantable Devices (2021)
  • Author(s): Tokuda Takashi、Yokoshiki Yasufumi、Takehara Hironari、Haruta Makito、Sasagawa Kiyotaka、Ohta Jun
  • Journal Title: IEEJ Transactions on Sensors and Micromachines Volume: 141 Issue: 3 Pages: 63-70
  • DOI: 10.1541/ieejsmas.141.63
  • NAID: 130007993097
  • ISSN: 1341-8939, 1347-5525
  • Year and Date: 2021-03-01
  • Peer Reviewed
• [Journal Article] Wearable and Battery-Free Health-Monitoring Devices With Optical Power Transfer (2021)
  • Author(s): Wuthibenjaphonchai Nattakarn、Haruta Makito、Sasagawa Kiyotaka、Tokuda Takashi、Carrara Sandro、Ohta Jun
  • Journal Title: IEEE Sensors Journal Volume: 21 Issue: 7 Pages: 9402-9412
  • DOI: 10.1109/jsen.2021.3050139
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] インプランタブル電子デバイス技術の最前線! (2021)
  • Author(s): 德田 崇
  • Journal Title: 日本電子回路工業会機関紙JPCA News Volume: 2021-03 Pages: 4-9
• [Journal Article] CMOS集積回路技術を用いたオンチップ光・電気イメージセンサ研究 (2020)
  • Author(s): 德田 崇, 横式 康史, 太田 淳
  • Journal Title: 化学センサ研究会機関紙"Chemical Sensors" Volume: 36 Pages: 120-126
• [Journal Article] 超小型ワイヤレス神経光刺激デバイスの創製 (2019)
  • Author(s): 徳田 崇，春田 牧人，野田 俊彦，笹川 清隆，太田 淳
  • Journal Title: 生物物理 Volume: 59 Pages: 156-160
  • NAID: 130007653134
  • Peer Reviewed / Open Access
• [Journal Article] Design Optimization of CMOS Control Circuit for Integrated Photovoltaic Power Transfer (2018)
  • Author(s): T. Tokuda, T. Ishizu, N. Wuthibenjaphonchai M. Haruta, T. Noda, K. Sasagawa, M. Sawan, and . Ohta
  • Journal Title: Sensors and Materials Volume: 30 Issue: 10 Pages: 2343
  • DOI: 10.18494/SAM.2018.1945
  • ISSN: 0914-4935, 2435-0869
  • Year and Date: 2018-10-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 1 mm3-sized Optical Neural Stimulator based on CMOS Integrated Photovoltaic Power Receiver (2018)
  • Author(s): T. Tokuda, T. Ishizu, W. Nattakarn, M. Haruta, T. Noda, K. Sasagawa, M. Sawan, and J. Ohta
  • Journal Title: AIP Advances Volume: 8 Issue: 4 Pages: 45018-45018
  • DOI: 10.1063/1.5024243
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CMOS-based optical energy harvesting circuit for biomedical and Internet of Things devices (2018)
  • Author(s): Wuthibenjaphonchai Nattakarn, Takaaki Ishizu, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Mohamad Sawan and Jun Ohta
  • Journal Title: Japanese Journal of Applied Physics Volume: 57 Issue: 4S Pages: 04FM05-04FM05
  • DOI: 10.7567/jjap.57.04fm05
  • NAID: 210000148977
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 超小型生体埋め込みデバイス向け光給電技術 (2021)
  • Author(s): 德田 崇
  • Organizer: レーザー学会学術講演会第41回年次大会
  • Invited
• [Presentation] 光駆動型ワイヤレス生体光刺激デバイスの構造改善 (2021)
  • Author(s): Jiawen Li, 深町賢人, 竹内瑞希, 横式康史, 德田 崇
  • Organizer: 令和3年電気学会全国大会
• [Presentation] CMOSチップ分散型アーキテクチャによる光電気神経インターフェースデバイスの研究 (2021)
  • Author(s): 松岡 聡, 横式 康史, 徳田 崇
  • Organizer: 第68回応用物理学会春季学術講演会
• [Presentation] CMOS-based ultra-small devices for biomedical and IoT applications (2020)
  • Author(s): Takashi Tokuda
  • Organizer: 9th imec Handai International Symposium
  • Int'l Joint Research / Invited
• [Presentation] バイオとIoTのための光電力伝送・エナジーハーベスティング技術 (2020)
  • Author(s): 德田 崇
  • Organizer: 電子情報技術産業協会(JEITA) スマートセンシング・デバイス融合技術分科会
  • Invited
• [Presentation] バイオ＆IoT応用を目指した光駆動マイクロエレクトロニクス (2020)
  • Author(s): 德田 崇
  • Organizer: 2020年度第2回センサ＆IoTコンソーシアム技術委員会オンラインセミナー
  • Invited
• [Presentation] 1mm3-sized optogenetic stimulator with CMOS-integrated optical power receiver (2019)
  • Author(s): Takashi Tokuda, Makito Haruta, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: The 1st Optical Wireless and Fiber Power Transmission Conference, パシフィコ横浜
  • Int'l Joint Research / Invited
• [Presentation] Implantable optoelectronic devices based on CMOS LSI technology (2019)
  • Author(s): Takashi Tokuda, Makito Haruta, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: ACS Fall 2019 National Meeting & Exposition in San Diego, CA
  • Int'l Joint Research
• [Presentation] 生体埋め込みデバイス向けワイヤレス光電力伝送技術 (2019)
  • Author(s): 德田 崇, Pakpuwadon Thanet, Wuthibenjaphonchai Nattakarn, 春田 牧人, 笹川 清隆, 太田 淳
  • Organizer: 電気学会総合研究会
• [Presentation] 生体埋め込みデバイス向けワイヤレス光電力伝送技術 (2019)
  • Author(s): 德田 崇, Pakpuwadon Thanet, Wuthibenjaphonchai Nattakarn, 春田 牧人, 笹川 清隆, 太田 淳
  • Organizer: 電気学会マイクロマシン・センサシステム／バイオ・マイクロシステム合同研究会
• [Presentation] Optical power transfer platform for ultra-small implantable device with alternative current limitations (2019)
  • Author(s): Thanet Pakpuwadon, Nattakarn Wuthibenjaphonchai, 春田 牧人, 笹川 清隆, 德田 崇, 太田 淳
  • Organizer: LSIとシステムのワークショップ2019、東京大学生産技術研究所
• [Presentation] Ultra-Small Optogenetic Simulator Powered by CMOS-Integrated Optical Power Receiver (2019)
  • Author(s): Thanet Pakpuwadon、Nattakarn Wuthibenjaphonchai、Makito Haruta、Toshihiko Noda、Kiyotaka Sasagawa、Takashi Tokuda、Jun Ohta、Mohamad Sawan
  • Organizer: 第79回応用物理学会秋季学術講演会(日本、名古屋国際会議場)
• [Presentation] サル脳深部用刺入型光利刺激デバイスの作製と評価 (2019)
  • Author(s): 川崎 祐久、長沼 京介、太田 安美、春田 牧人、笹川 清隆、徳田 崇、太田 淳
  • Organizer: 第66回応用物理学会春季学術講演会(日本、東京工業大学)
• [Presentation] CMOS-integrated optical power transfer for an ultra-small wireless implantable devices (2018)
  • Author(s): T. Pakpuwadon, W. Nattakarn, M. Haruta, T. Noda, K. Sasagawa, T. Tokuda, M. Sawan, J. Ohta
  • Organizer: International Conference on Solid State Devides and Materials (SSDM2018), Univ. Tokyo
  • Int'l Joint Research
• [Presentation] CMOS技術によるオンチップエレクトロバイオロジー (2018)
  • Author(s): 徳田 崇、春田牧人、野田俊彦、笹川清隆、太田 淳
  • Organizer: 平成30年電気学会全国大会
  • Invited
• [Presentation] CMOS-based optoelectronic devices for biomedical applications (2017)
  • Author(s): Takashi Tokuda
  • Organizer: The first International Workshop by the 174th Committee JSPS on Symbiosis of Biology and Nanodevices
  • Int'l Joint Research / Invited
• [Presentation] CMOS技術によるバイオメディカル/IoTフォトニックデバイス (2017)
  • Author(s): 徳田崇、春田牧人、野田俊彦、笹川清隆、太田淳
  • Organizer: 電子情報通信学会 集積光デバイスと応用技術特別研究専門委員会(IPDA) 2017年第2回研究会
  • Invited
• [Presentation] CMOS-Based Opto-Electric Neural Interface Devices for Optogenetics (2017)
  • Author(s): Takashi Tokuda, Makito Haruta, Toshihiko Noda, Kiyotaka Sasagawa, Jun Ohta
  • Organizer: 60th International Midwest Symposium on Circuits and Systems
  • Int'l Joint Research / Invited
• [Presentation] CMOS-based integrated opto-electric neural interface devices (2017)
  • Author(s): T. Tokuda, M. Haruta, T. Noda, K. Sasagawa, and J. Ohta
  • Organizer: 9th International Conference on Molecular Electronics and bioelectronics
  • Int'l Joint Research / Invited