Development of near-field Raman microscope utilizing fluctuation

• Project/Area Number: 17H02725
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nanostructural chemistry
• Research Institution: Gakushuin University
• Principal Investigator: Saito Yuika 学習院大学, 理学部, 教授 (90373307)
• Co-Investigator(Kenkyū-buntansha): 佐甲 徳栄 日本大学, 理工学部, 准教授 (60361565)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2017: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
• Keywords: ラマン分光 / 表面増強ラマン散乱 / ゆらぎ / クラスター分析 / 近接場光学 / 微弱光測光 / シングルパルスラマン分光 / 近接場分光 / 大容量データ / 機械学習 / スペクトル分解能 / ナノ材料 / シングルパルス / バルクヘテロジャンクション太陽電池 / プラズモニクス / 脂質二重膜 / ナノコンタクト

Outline of Final Research Achievements

We established a method to detect weak Raman scattering signals by taking into signal fluctuation into the measurement scheme. The fluctuation time scale of surface enhanced Raman scattering is approximately nano second which is influenced by Brownian motion of a molecule in liquid under room temperature. We measured thousands of Raman spectra with exposure time of a single nano-second pulse duration time, followed by deta selection procedure. Density-Based Spatial Clustering Analysis with Noize (DBSCAN) was employed for data analysis. We successfully reconstructed Raman spectra with high SN ratio.

Academic Significance and Societal Importance of the Research Achievements

非侵襲で分子固有の信号を与えるラマン分光を、安定して単分子レベルで行うことは、近年の分光学の究極の目標の一つである。本研究では、従来の高感度ラマン分光で問題であった信号ゆらぎを測定に組み込み、大容量データ取得とデータ選別法を組み合わせた超高感度分析手法を開発した。ここで開発したデータ解析手法は、生物試料等の複雑系、食品や医薬品分析に幅広く適用可能である。本手法は、計算機のCPU速度およびメモリの容量を増大させることで精度を高めることができるため、コンピュータの進歩とともに今後ますます発展することが予想される。

Research Products

• [Journal Article] Low frequency Raman study of interlayer couplings in WS2-MoS2 van der Waals heterostructures (2020)
  • Author(s): Saito Y, Kondo T, Ito H, Okada M, Shimizu T, Kubo T, Kitaura R
  • Journal Title: Japanese Journal of Applied Physics Volume: 59 Issue: 6 Pages: 062004-062004
  • DOI: 10.35848/1347-4065/ab9400
  • Peer Reviewed
• [Journal Article] Vapor-deposited Au thin films modified by plasma etching for surface-enhanced Raman scattering active substrates (2020)
  • Author(s): Kondo T, Tomida A, Morishita N, Saito Y
  • Journal Title: Journal of Applied Physics Volume: 127 Issue: 9
  • DOI: 10.1063/1.5139586
  • Peer Reviewed
• [Journal Article] Near-UV plasmon resonances for enhanced TiO2 photocatalysis (2020)
  • Author(s): Honda Mitsuhiro、Hizumi Kohki、Devi Rajkumari Irena、Tiwari Nishtha、Saito Yuika、Ichikawa Yo
  • Journal Title: Japanese Journal of Applied Physics Volume: 59 Issue: 4 Pages: 045001-045001
  • DOI: 10.35848/1347-4065/ab809b
  • Peer Reviewed
• [Journal Article] Longitudinal strain of epitaxial graphene monolayers on SiC substrates evaluated by z-polarization Raman microscopy, (2019)
  • Author(s): Saito Y, Tokiwa K, Kondo T, Bao J, Terasawa T, Norimatsu W, Kusunoki M
  • Journal Title: AIP Advances Volume: 9 Issue: 6 Pages: 065314-065314
  • DOI: 10.1063/1.5099430
  • Peer Reviewed / Open Access
• [Journal Article] Tapered arrangement of metallic nanorod chains for magnified plasmonic nanoimaging (2019)
  • Author(s): Ohashi Y, Ranjan B, Saito Y, Umakoshi T, Verma P
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2656-2663
  • DOI: 10.1038/s41598-019-39624-1
  • Peer Reviewed
• [Journal Article] Plasmonic transfer of near-field light from subwavelength objects through a gold-nanorod chain (2018)
  • Author(s): Ohashi Y, Ranjan B, Saito Y, Umakoshi T, Verma P
  • Journal Title: Applied Physics Express Volume: 11 Issue: 10 Pages: 102001-102005
  • DOI: 10.7567/apex.11.102001
  • NAID: 210000136367
  • Peer Reviewed
• [Journal Article] Raman imaging of lipid bilayer membrane by surface enhanced Raman scattering, SPIE Biomedical Vibrational Spectroscopy (2018)
  • Author(s): Mori M, Abe S, Kondo T, Saito Y
  • Journal Title: Proc. SPIE Volume: 10490 Pages: 1049001-1049009
  • DOI: 10.1117/12.2286839
  • Peer Reviewed
• [Journal Article] Direct and Indirect Interlayer Excitons in a van der Waals Heterostructure of hBN/WS2/MoS2/hBN (2018)
  • Author(s): Okada M, Kutana A, Kureishi Y, Kobayashi Y, Saito Y, Saito T, Watanabe K, Taniguchi T, Gupta S, Miyata Y, Yakobson BI, Shinohara H, Kitaura R
  • Journal Title: ACS Nano Volume: 12 Issue: 3 Pages: 2498-2505
  • DOI: 10.1021/acsnano.7b08253
  • NAID: 120006496402
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 単一半導体ナノ粒子の散乱分光 (2019)
  • Author(s): Takahiro Kondo, Kenta Hirose, Mahiro Hanazawa, Ryosuke Kojima, Takeru Yumoto, Yuika Saito
  • Organizer: 第80回応用物理学会秋季学術講演会
• [Presentation] Spectroscopic analysis of wide-gap semiconductor nanoparticle (2019)
  • Author(s): Yuika Saito, Takahiro Kondo, Kenta Hirose, Mahiro Hanazawa
  • Organizer: SPIE Optics Photonics 2019
  • Int'l Joint Research
• [Presentation] Individual semiconductor nano-particles evaluated by UV spectroscopy (2019)
  • Author(s): Y. Saito, T. Kondo, K. Hirose, M. Hanazawa
  • Organizer: 日本分光学会紫外フロンティア分光部会
  • Invited
• [Presentation] UV Rayleigh Scattering Spectroscopy of Semiconductor Nano-particles (2018)
  • Author(s): Y.Saito, T. Kondo, K. Hirose,M. Hanazawa, R. Kojima
  • Organizer: SciX2018
  • Int'l Joint Research / Invited
• [Presentation] ラマンイメージングによるP3HT/PCBMバルクヘテロ型有機混合薄膜の固体構造の評価 (2018)
  • Author(s): 森基彰, 石渡瑞枝, 近藤崇博, 齊藤結花
  • Organizer: 応用物理学会 第79回秋季学術講演会
• [Presentation] 蒸着金薄膜の微細化による表面増強ラマン散乱活性基板 の開発 (2018)
  • Author(s): 近藤崇博,富田輝,齊藤結花
  • Organizer: 応用物理学会第79回秋季学術講演会
• [Presentation] 三酸化タングステン単一ナノ粒子のバンドギャップ観測 (2018)
  • Author(s): 広瀬健太,花澤真優,近藤崇博,齊藤結花
  • Organizer: 応用物理学会第79回秋季学術講演会
• [Presentation] 表面増強ラマン散乱を用いた脂質二重膜のラマンイメージング (2018)
  • Author(s): 森基彰, 安倍駿輔, 近藤崇博, 齊藤結花
  • Organizer: 応用物理学会 第78回秋季学術講演会
• [Presentation] 紫外共鳴レーリー散乱による半導体単一ナノ粒子測定 (2018)
  • Author(s): 広瀬健太,近藤崇博, 齊藤結花
  • Organizer: 応用物理学会 第78回秋季学術講演会
• [Presentation] Raman imaging of lipid bilayer membrane by surface enhanced Raman scattering (2018)
  • Author(s): Motoaki Mori, Shunsuke Abe, Takahiro Kondo, Yuika Saito
  • Organizer: SPIE Phtotonics West 2018
  • Int'l Joint Research
• [Presentation] Laser ablation in water for Sn-based nanomaterials synthesis by millisecond-pulsed laser (2018)
  • Author(s): Takahiro Kondo, Sergei A. Kulinich, Yuika Saito and Satoru Iwamori
  • Organizer: SPIE Phtotonics West 2018
  • Int'l Joint Research